Saliva oxytocin, cortisol, and testosterone levels in adolescent boys with autism spectrum disorder, oppositional defiant disorder/conduct disorder and typically developing individuals

Bakker-Huvenaars, M.J.; Greven, Corina U.; Herpers, Pierre C. M.; Wiegers, Evita C; Jansen, Annemarie; Steen, R. van der; Herwaarden, Antonius E. van; Baanders, Arianne N.; Nijhof, Karin S.; Scheepers, Floortje; Rommelse, Nanda; Glennon, Jeffrey; Buitelaar, Jan K.

doi:10.1016/j.euroneuro.2018.07.097

Cited by 47 publications

(58 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table S1 in Supplementary Materials provides an overview of the 52 studies published from 2015 to 2020, included in the review for analysis. Among the 52 studies, most authors reported results on more than one dimension of the model, e.g., [ 69 , 70 ], 47 reported effects on mental health, e.g., [ 71 , 72 , 73 ] or on neurobiological features, e.g., [ 69 , 74 , 75 ], 22 on social contexts, e.g., [ 36 , 76 ], eight on social adjustment, e.g., [ 77 , 78 ], 10 on social roles and social interactions, e.g., [ 79 , 80 ] and 19 on executive functions or cognition, e.g., [ 81 , 82 ]. The majority (k = 17) were carried out in the USA, e.g., [ 83 , 84 ], two in Canada [ 70 , 85 ], two in Australia, two in Israel, the one in Europe (Spain, Germany, Netherlands, etc.).…”

Section: Resultsmentioning

confidence: 99%

“…Studies generally indicated that boys with CU traits are more likely to experience developmental difficulties than girls. The ratio of girls to boys (65% boys; 35% girls) should be assessed with caution, as several studies included only samples of boys in their studies [ 69 , 75 ]. This caution is all the more relevant since, in studies including similar numbers of girls and boys, the number of girls was proportionally higher in the control group than in the experimental one.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review

Squillaci

Benoit

2021

IJERPH

View full text Add to dashboard Cite

Numerous studies have shown that youth with behavioral disorders (BD) present an increased risk for developing severe and persistent antisocial behaviors in adulthood. Retrospective research notes that not all children and adolescents follow a negative trajectory and explains this heterogeneity in particular by the severity of CU traits. Our study examines how these traits affect the functioning of children and adolescents with BD. Method: A systematic literature review conducted through various databases and using different keywords made it possible to analyze 52 studies published from 2015 to 2020 that measured the bidirectional effects of CU traits on the functioning of young. Results: Out of the 52 studies, 47 analyzed links between CU traits and neurobiological or mental health, 20 examined family and school contexts, eight focused on social adjustment, 10 on social interactions and 19 measured links with cognitive functioning, especially executive functions. Conclusion: Consistent with previous recommendations in the field, our findings emphasize the importance of assessing the presence of UC traits in early childhood to prevent the emergence of comorbid disorders and to target multimodal (early) interventions to influence the life trajectories of youth with high CU traits.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review

Squillaci

Benoit

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Testosterone is a sex hormone that has been implicated in the modulation of PFC; when increased, it may affect the fear-processing circuitry, which has been associated with reactive and abnormal aggression responses [50,51] Curiously, the up-regulated pathway showing the highest over-representation in the group of animals displaying agonistic behavior (4.32 fold enrichment), includes genes associated with blood coagulation. The links between the blood coagulation system and behavior are increasingly being recognized.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiles Underlying Aggressive Behavior in the Prefrontal Cortex of Cattle

Eusebi

Sevane

́Rourke

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Aggressive behavior is an ancient and conserved trait habitual for most animals in order to eat, protect themselves, compete for mating and defend their territories. Genetic factors have been shown to play an important role in the development of aggression both in animals and humans, displaying moderate to high heritability estimates. Although, such types of conducts have been studied in different animal models, the molecular architecture of aggressiveness remains poorly understood. This study compared gene expression profiles of 16 prefrontal cortex (PFC) samples from aggressive and non-aggressive cattle breeds: Lidia, selected for agonistic responses, and Wagyu, selected for tameness. Results: A total of 918 up-regulated and 278 down-regulated DEG were identified. The functional interpretation of the up-regulated genes in the aggressive cohort revealed enrichment of pathways such as the Alzheimer disease-presenilin, integrins or the ERK/MAPK signaling cascade, all implicated in the development of abnormal aggressive behaviors and neurophysiological disorders. Moreover, gonadotropins, are also up-regulated as natural mechanisms enhancing aggression. Concomitantly, heterotrimeric G-protein pathways, associated with low reactivity mental states, and the GAD2 gene, a repressor of agonistic reactions associated with PFC activity, are down-regulated, promoting the development of the aggressive responses selected for in Lidia cattle. We also identified six upstream regulators, whose functional activity fits with the etiology of abnormal behavioral responses associated with aggression. Conclusions: These transcriptional correlates of aggression, resulting, at least in part, from controlled artificial selection, can provide valuable insights into the complex architecture that underlies naturally developed agonistic behaviors.This analysis constitutes a first important step towards the identification of the genes and metabolic pathways that impulse aggression in cattle and, hence, we are providing a novel species as model organism for disentangling the mechanisms underlying variability in aggressive behavior.

show abstract

“…There are several studies reporting that ASD could be a result of oxytocin system disturbances early in life (Quattrocki and Friston, 2014). Oxytocin levels have been found to be decreased in the saliva of adolescent boys with autism (Bakker-Huvenaars et al, 2018), as well as in the plasma of Chinese autistic patients (Zhang et al, 2016). However, another group of autistic children and adolescents exhibited elevated serum oxytocin levels (Yang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Pioglitazone abolishes cognition impairments as well as BDNF and neurotensin disturbances in a rat model of autism

et al. 2019

View full text Add to dashboard Cite

We have shown that exposure of rats to lipopolysaccharide (LPS) during gestation induces autistic-like behaviors in juvenile offspring and pioglitazone post treatment corrects social and communication deficits. The first objective of the present study was to evaluate the cognition of the rats, because this is also a behavioral sphere committed in autism. Second, biomarkers related to pioglitazone pathways and autism were studied to try to understand their mechanisms. We used our rat model of autism and pioglitazone was administered daily to these young offspring. T-maze spontaneous alternations tests, plasma levels of brain-derived neurotrophic factor (BDNF), beta-endorphin, neurotensin, oxytocin, and substance P were all studied. Exposure of rats to LPS during gestation induced cognitive deficits in the young offspring, elevated BDNF levels and decreased neurotensin levels. Daily postnatal pioglitazone treatment abolished cognition impairments as well as BDNF and neurotensin disturbances. Together with our previous studies, we suggest pioglitazone as a candidate for the treatment of autism, because it improved the responses of the three most typical autistic-like behaviors. BDNF and neurotensin also appeared to be related to the autistic-like behaviors and should be considered for therapeutic purposes.

show abstract

Saliva oxytocin, cortisol, and testosterone levels in adolescent boys with autism spectrum disorder, oppositional defiant disorder/conduct disorder and typically developing individuals

Cited by 47 publications

References 79 publications

Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review

Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review

Gene Expression Profiles Underlying Aggressive Behavior in the Prefrontal Cortex of Cattle

Pioglitazone abolishes cognition impairments as well as BDNF and neurotensin disturbances in a rat model of autism

Contact Info

Product

Resources

About