2020
DOI: 10.1159/000505921
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Salivary Aldosterone, Cortisol, and Their Morning to Evening Slopes in Patients with Depressive Disorder and Healthy Subjects: Acute Episode and Follow-Up 6 Months after Reaching Remission

Abstract: Background/Objective: Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course of clinical depression with the assumption that aldosterone is a state marker of depression. Methods: A total of 78 adult subjects (39 patients with depressive disorder and 39 healthy controls)… Show more

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Cited by 17 publications
(20 citation statements)
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“…To date, there are no other studies investigating morning to evening aldosterone slopes in relation to PMS. Interestingly, we have described a flatter morning to evening slope for aldosterone in patients with acute depressive episode 14 and a flatter morning to midday slope in depressed children. 32 In the present study, the diurnal slopes for cortisol in women with PMS were not different from those in control women throughout the menstrual cycle.…”
Section: Discussionmentioning
confidence: 75%
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“…To date, there are no other studies investigating morning to evening aldosterone slopes in relation to PMS. Interestingly, we have described a flatter morning to evening slope for aldosterone in patients with acute depressive episode 14 and a flatter morning to midday slope in depressed children. 32 In the present study, the diurnal slopes for cortisol in women with PMS were not different from those in control women throughout the menstrual cycle.…”
Section: Discussionmentioning
confidence: 75%
“…The obtained data were first checked for normality of distribution by Shapiro-Wilk test and subsequently winsorized using a 15% two- Morning to evening slopes of aldosterone and cortisol for each participant was calculated as described previously. 14 The values of angular coefficients were analyzed by a t test for independent groups.…”
Section: Discussionmentioning
confidence: 99%
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“…It was, however, already stated by the founder of the stress concept Hans Selye (2). More recently, aldosterone has been recognized as a potential biomarker of the depressive state as supported by clinical (3)(4)(5) and preclinical data (6)(7)(8)(9)(10). Of importance is that markers of increased aldosterone action via central mineralocorticoid receptors appear to be associated with therapy resistance to standard antidepressants (11,12).…”
Section: Introductionmentioning
confidence: 99%