Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients

Tanaka, Yoshihiro; Ishitobi, Yoshinobu; Maruyama, Yoshihiro; Kawano, Aimi; Ando, Tomoko; Okamoto, Shizuko; Kanehisa, Masayuki; Higuma, Haruka; Ninomiya, Taiga; Tsuru, Jusen; Hanada, Hiroaki; Kodama, Kensuke; Isogawa, Koichi; Akiyoshi, Jotaro

doi:10.1016/j.pnpbp.2011.10.005

Cited by 41 publications

(37 citation statements)

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“…These results are also consist with borderline personality disorder, obsessive‐compulsive disorder, panic disorder, and MDD (Tanaka et al. 2012a,b; Kawano et al. 2013; Inoue et al.…”

Section: Discussionmentioning

confidence: 99%

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Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

et al. 2016

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IntroductionsAvoidant personality disorder (AVPD) has excessive and pervasive anxiety and discomfort in social situations. The aims of this study were to explore the relationship between AVPD and physical and psychological stress and psychological tests.MethodsWe evaluated 93 AVPD patients and 355 nonpatient controls by salivary amylase and cortisol responses during exposure to the Trier Social Stress Test (TSST) and electrical stimulation stress. Spielberger state‐trait anxiety inventory (STAI), Profile of Mood State (POMS), Beck Depression Inventory (BDI), Depression and Anxiety Cognition Scale (DACS), and Childhood Trauma Questionnaire (CTQ) were administered.ResultsFollowing electrical stimulation, salivary cortisol levels in female AVPD decreased significantly less than that in female's controls, but salivary cortisol levels did not show a difference between male AVPD patients and controls. Salivary alpha‐amylase (sAA) levels did not show a difference between females or male AVPD patients and controls. Following TSST exposure, sAA levels did not show a difference between females or male AVPD patients and controls. Salivary cortisol levels did not show a difference between females or male AVPD patients and controls. In the AVPD patients, POMS scores were significantly higher compared with the controls. STAI, BDI, DACS scores, and CTQ significantly increased in the AVPD patients compared with the controls. LF in heart rate variability in AVPD significantly increased more compared with controls.ConclusionsThese results suggest that heightened sympathetic reactivity in female AVPD co‐occurs with attenuated salivary cortisol responses to electric stimulation stress and there is a significant difference between AVPD and controls in mood, anxiety, social cognition, and automatic nerve systems.

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“…These results are also consist with borderline personality disorder, obsessive‐compulsive disorder, panic disorder, and MDD (Tanaka et al. 2012a,b; Kawano et al. 2013; Inoue et al.…”

Section: Discussionmentioning

confidence: 99%

“…The threshold of electrical stimulation may be dependent on interindividual differences related to psychological factors such as depression and anxiety (Tanaka et al. 2012a,b). Moreover, the strength of the stimulation was determined by each subject.…”

Section: Methodsmentioning

confidence: 99%

Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

et al. 2016

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“…When the levels were higher than normal, they were expressed as stress (> 60 KU/l). 11 The group suffering from more severe periodontal disease (periodontitis) demonstrated a tendency towards higher levels of stress. Such elevated levels were in accordance with the findings of research conducted by Shende which suggested that psychosocial factors such as severe stress, personality type and individual coping strategies to deal with a stress environment can modify the immune response.…”

Section: Discussionmentioning

confidence: 99%

“…It was then inserted into the Cocorometer tool ( Figure 1B). 11 The results of alpha-amylase levels were recorded on the Cocorometer's monitor which operates on the basis that a rise in norepinephrine will affect the level of alpha-amylase in human saliva ( Figure 1C). Alphaamylase reacts faster than cortisol and norepinephrine to acute stress.…”

Section: Methodsmentioning

confidence: 99%

“…5,7,8 Tanaka et al identified a practical, Japanesemade tool (the Nipro Cocorometer) for measuring stress based on alpha-amylase levels in saliva. 11 Using a Cocorometer, the present study measured alpha-amylase levels in patients afflicted with gingivitis and periodontitis. Furthermore, these levels are used as stress parameters when observing the relationship between periodontal disease and psychological stress.…”

Section: Introductionmentioning

confidence: 99%

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