Salivary and Serum Antioxidants in Women with Preeclampsia with or Without Periodontal Disease

Shetty, Mamatha; Ramesh, Amitha; Shetty, Prakashchandra; Agumbe, Priyanka

doi:10.1007/s13224-017-0993-4

Cited by 19 publications

(21 citation statements)

References 17 publications

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“…Furthermore, some studies have shown that periodontal disease may Table 3. Distribution of case and control groups according to the presence or absence of periodontal disease, categorized by the pregnancy-induced hypertension status be a potential risk factor for the initiation and development of preeclampsia because of the reduced antioxidant capacity and increased oxidative stress or free radicals [27,28]; therefore, we hypothesized that periodontitis during pregnancy was associated with preeclampsia. Several studies have reported the relationship between periodontitis and preeclampsia [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

Ahmadi

Lor²,

Sayar

et al. 2018

J Islam Dent Assoc Iran

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Background and Aim: Preeclampsia is a considerable complication of pregnancy. Chronic inflammations such as periodontitis may lead to a transient low-grade bacteremia in the maternal-fetal circulation, inducing systemic immune responses, placental abnormalities, and other clinical manifestations of preeclampsia. There are inconsistent findings regarding the correlation between periodontitis and preeclampsia. The aim of this study was to compare periodontal parameters in preeclamptic and normotensive pregnant women. Materials and Methods: This case-control study was conducted among pregnant women visiting Akbarabadi Teaching Hospital, Tehran, Iran, for specialized care during 2015-16. From among 260 pregnant women, 100 with gestational hypertension were selected as the case group, and 100 without gestational hypertension were recruited as the control group. The examined periodontal parameters included Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP), and Plaque Control Record (PCR). The participants' demographic data, prenatal history, and family history were collected through interviewing and assessing their medical records. Data were analyzed by Mann-Whitney U test. Results: Although there were significant statistical differences between the groups with regards to the mean ± standard deviation (SD) of PD (P<0.0001), CAL (P<0.0001), PCR (P=0.001), and BOP (P=0.016) indices, yet the differences were clinically smaller than 0.3 mm and could not be measured with a periodontal probe. Also, the percentage of periodontal diseases was 98% in preeclamptic women and 93% in normotensive women (P=0.17). Conclusion: The present study did not support the theory of the relationship between periodontal parameters and preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

Ahmadi

Lor²,

Sayar

et al. 2018

J Islam Dent Assoc Iran

View full text Add to dashboard Cite

show abstract

“…It is supported that periodontal diseases are related with adverse pregnancy effects [54]. One of the possible mechanisms underlying this interaction stated that there may be oxidative stress-related inflammation pathways in case of pregnancy and periodontal disease [5,27]. Oxidative stress is a principal supporting factor in the pathogenesis of preeclampsia and periodontal disease [27].…”

Section: Pregnancymentioning

confidence: 99%

“…One of the possible mechanisms underlying this interaction stated that there may be oxidative stress-related inflammation pathways in case of pregnancy and periodontal disease [5,27]. Oxidative stress is a principal supporting factor in the pathogenesis of preeclampsia and periodontal disease [27]. Çanakçı et al [40] evaluated the GSH-Px levels in serum, saliva, and GCF in preeclamptic and normotensive pregnant women with and without periodontal disease.…”

Section: Pregnancymentioning

confidence: 99%

“…They declared that systemic and local GSH-Px activities reduced with the effect of periodontal disease in addition to the impact of preeclampsia [40]. Similarly Shetty et al [27] observed that the GSH-Px activity in serum and saliva elevated in normotensive pregnant women with healthy periodontium when compared with preeclampsia pregnant women with and without periodontitis, and also preeclamptic women with periodontitis group have the lowest values but statistically nonsignificant. They indicated that periodontal diseases which cause a reduction in antioxidant levels could be a likelihood risk factor for severity, progression, and even initiation of preeclampsia [27].…”

Section: Pregnancymentioning

confidence: 99%

“…GSH-Px is one of the enzymes that has a significant role in host defense averse to oxidative stress in cytosol [1,18]. GSH-Px1 inhibits cytotoxic peroxide-induced oxidative damage, protein degeneration, and lipid peroxidation [27].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Periodontal Health and Disease in Glutathione Peroxidase

Dede¹

2020

Glutathione System and Oxidative Stress in Health and Disease

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Periodontal diseases are chronic, multifactorial inflammatory diseases that affect more than 10% of the world population. There are two general forms of periodontal diseases including gingivitis (reversible inflammation and confined with gingiva form) and periodontitis (irreversible, destruction form). Several studies have reported that periodontal disease was associated with a decreased antioxidant capacity and elevated oxidative damage within the oral cavity. Glutathione peroxidase (GSH-Px) is an important enzymatic antioxidant that protects periodontal tissues against oxidative stress. Hitherto, there is contradictory evidence concerning the relationship between the levels of GSH-Px and the periodontal status. Various studies have demonstrated that GSH-Px levels in different biological fluids increased, decreased, or are unaltered in individuals with periodontal disease. This discrepancy might be explained either by different determination protocols/assays applied among the studies or various dynamic processes of the periodontal disease progression. In this section, GSH-Px levels are summarized in the periodontal health and disease including the presence and absence of systemic disease, medication, wound healing, and smoking.

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Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women

Shaheen

Jahan

Ain

et al. 2019

Molec Gen & Gen Med

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Background: Preeclampsia (PE): a hypertensive disorder of pregnancy characterized by de novo development of concurrent hypertension and proteinuria. The prevailing theory determined that PE starts from the placenta and ends in the maternal endothelium. Role of endothelial dysfunction in the onset of PE has been reported in different populations. Therefore, present study was designed to investigate the localization and expression of endothelial nitric oxide synthase (eNOS) and role of oxidative stress markers in preeclamptic Pakistani women. Methods: A total of 400 blood samples (PE = 200, controls = 200) and 100 placental tissues (PE = 50, controls = 50) were recruited from pregnant women. Reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (POD) levels were analyzed through spectrophotometer. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) were carried out to estimate the localization and expression of eNOS in the placentas of PE patients and healthy pregnant women. Results: Significantly increased levels of POD (0.01), TBARS (0.04), and ROS (p ≤ .001) were determined in preeclamptic women while, nonsignificant changein SOD and CAT was observed in both groups. Reduced eNOS immunoreactivity (p ≤ .001) and mRNA abundance (p ≤ .001) was observed in preeclamptic group as compared to control group. Conclusion: Considering the results of current study, it is concluded that decreased eNOS expression and oxidative stress could play a role in the pathology of PE seen both in placenta and ultimately in maternal endothelium. However, large studies are necessary to validate these findings to prevent maternal and neonatal morbidity and mortality in Pakistani population. K E Y W O R D Sendothelial nitric oxide synthase, oxidative stress, placenta, preeclampsia

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Salivary and Serum Antioxidants in Women with Preeclampsia with or Without Periodontal Disease

Abstract: The results of our study show that periodontal disease may be potential risk factor for severity, progression, and even initiation of preeclampsia because of reduced antioxidant capacity or increased oxidative stress.

Cited by 19 publications

References 17 publications

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

Evaluation of the Association Between Maternal Periodontal Health and Preeclampsia

Periodontal Health and Disease in Glutathione Peroxidase

Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women

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