Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool

Stoof, Susanne P.; Klis, Fiona R.M. van der; Rooijen, Debbie M. van; Bogaert, Debby; Trzciński, Krzysztof; Sanders, Elisabeth A. M.; Berbers, Guy A. M.

doi:10.1016/j.vaccine.2015.06.055

Cited by 17 publications

(21 citation statements)

References 31 publications

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“…Table 1 outlines the number of participants with additional blood samples available for the current study together with GMCs of MenC-PS-specific antibody in serum and saliva. GMCs of MenC-PS-specific serum and salivary antibody levels in the current study population were similar to the GMCs in the total study population [ 15 , 16 ]. Gender distribution was similar across age groups (data not shown).…”

Section: Resultssupporting

confidence: 65%

“… NOTE: Geometric mean concentrations (GMCs) of serum antibody levels are presented in ng/ml to ease comparison with salivary antibody levels. GMCs of serum and salivary antibody levels of the total study population have been published previously [ 15 , 16 ]. …”

Section: Resultsmentioning

confidence: 99%

“…MenC-polysaccharide (MenC-PS) and tetanus toxoid (TT) specific IgG levels were determined using a fluorescent bead-based multiplex immunoassay (MIA) as previously described [ 15 , 18 , 19 ]. Levels of MenC-PS-specific IgA were measured using a modification of the MIA-protocol as previously described [ 16 , 20 ] with monoclonal mouse-anti-human IgA (Sigma) as primary antibody and R-phycoerythrin-conjugated goat-anti-mouse IgG (Jackson ImmunoResearch) as the subsequent conjugate.…”

Section: Methodsmentioning

confidence: 99%

“…Similar to the previously described age-dependent persistence after primary vaccination, we found that persistence of antibody levels in the first year after the booster correlated with age, with best persistence in the oldest age group of our study (15-year-olds) [ 15 ]. In addition, we found higher levels of IgA in saliva of the 12- and 15-year-olds in response to the booster compared to the 10-year-olds [ 16 ]. These differences between the age groups may be due to the difference in age at primary vaccination, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

et al. 2015

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BackgroundAntibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels.MethodsMeasurement of MenC-specific IgG and IgA memory B cells and levels of serum and salivary MenC-specific IgG and IgA in healthy 10-, 12- and 15-year-olds prior to and one month and one year after a MenCC booster vaccination. All participants had received a primary MenCC vaccination nine years earlier.ResultsThe number of circulating MenC-specific IgG memory B cells prior to booster was low and not predictive for MenC-specific IgG responses in serum or saliva post-booster, whereas the number of MenC-specific IgA memory B cells pre-booster positively correlated with MenC-specific IgA levels in saliva post-booster (R = 0.5, P<0.05). The booster induced a clear increase in the number of MenC-specific IgG and IgA memory B cells. The number of MenC-PS-specific IgG memory B cells at 1 month post-booster was highest in the 12-year-olds. The number of MenC-specific memory B cells at one month post-booster showed no correlation with the rate of MenC-specific antibody decay throughout the first year post-booster.ConclusionsCirculating MenC-specific IgA memory B cells correlate with IgA responses in saliva, whereas circulating MenC-specific IgG memory B cells are not predictive for MenC-specific IgG responses in serum or saliva. Our results are suggestive for age-dependent differences in pre-existing memory against MenC.

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

et al. 2015

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“…Moreover, depending on the specific tissue, efficient transport of dimeric IgA can occur through the polymeric Ig receptor resulting in secretory IgA in the lumen of mucosal surfaces such as the respiratory tract [91,92]. Although memory IgA B cells could be detected 1-year post-MenC vaccination, local IgA antibodies induced by vaccination may decline relatively fast [93,94]. Assessing IgA antibodies after vaccination often proves challenging, because well-defined control sera or serum panels with defined concentrations and general knowledge regarding protective antibody concentrations are lacking.…”

Section: Systemic Versus Local Responsesmentioning

confidence: 99%

Immune surveillance for vaccine-preventable diseases

Hartog

Binnendijk

Buisman

et al. 2020

Expert Review of Vaccines

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Introduction: Immunesurveillance is an important tool to monitor the protection of the population against vaccine-preventable diseases, which is currently mostly based on the detection of specific serum antibodies. However, the landscape of immune surveillance is changing, driven by emerging and evolving pathogens, changes in the age distribution of the population and scientific understanding of protective immunity, necessitating a comprehensive review. Areas covered: To anticipate these changes, reliable and high-throughput detection of antibody levels is desired to enable screening in larger population settings. Antibody levels alone do not always equate with protection and may require additional functional testing of the antibodies or immune cell-based assays. In addition, the location (systemic or locally mucosal) of the infection and whether the antibodies are induced through infection or vaccination have implications for both immune protection and assessing immune status. Expert commentary: In order to perform multicenter studies on many samples for multiple antigens, more validated reference materials and wider adoption of high-throughput techniques are needed. The field of serosurveillance will also benefit from better correlates of protection and understanding of (local) mechanisms of protection. Here we give an overview of the current state-of-the-art of serosurveillance and how the field could move forward. ARTICLE HISTORY

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Passive Immunization

Amanna¹

2018

Plotkin's Vaccines

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Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool

Cited by 17 publications

References 31 publications

Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?

Immune surveillance for vaccine-preventable diseases

Passive Immunization

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