Salivary Antioxidants Are Increased In Adolescents With Down Syndrome After A 12-week Training Program

Abstract

It is generally accepted individuals with Down syndrome suffer from higher oxidative damage when compared to matched-healthy siblings. Fortunately we have recently found aerobic training at low/moderate intensity improved antioxidant defense system and reduced both lipoperoxidation and protein oxidation. To assess these parameters most studies use blood samples. Accordingly to our knowledge there is little information regarding its influence in non-invasive biomarkers of antioxidant system in Down syndrome. PURPOSE:For the reasons already mentioned the present study was undertaken to ascertain the influence of aerobic training in salivary antioxidants in adolescents with Down syndrome. This is of particulat interest since saliva, the most available and non-invasive biofluid of the human body, has an important antioxidant defense system. METHODS:To get this goal 31-adolescents with Down syndrome (16.3±1.1 years old; 166.4±4.5 cm; 78.7±4.8 kg; 31.8±3.7% fat mass percentage) performed a 12-week training program in treadmill with 3 days/week, consisting of warm-up (15min), main part (20-35min) at a work intensity of 60-75% of peak heart rate (HRmax=194.5-[0.56 age]) and cool-down (10min). Control group included 7 age, sex and BMI-matched adolescents with trisomy 21 that did not perform any training program. Salive Total Antioxidant Status (TAS) was assessed by spectrophotometric methods using commercially available kits. Samples were obtained in the morning following a overnight fast and stored at small aliquots at -40ºC. It should be pointed out his study complied with the ACSM statement regarding the use of human subjects and informed consent.

Better Health Through Exercise: Self-Management of Activity Tracking by Individuals with Intellectual Disabilities

“…Individuals with ID often have health care concerns such as diabetes, kidney disease, severe allergies, progressive illnesses, respiratory weaknesses, and obesity. The National Survey of Children with Special Health Care Needs Survey (Centers for Disease Control and Prevention, 2005-2006, 2009 indicated individuals with disabilities with special health care needs often fail to learn how to manage their health issues and access needed health care services, which puts them at risk for failure in being able to hold a job, get a higher education degree, and live independently in the community. Rimmer et al (2010) found youths with autism and Down syndrome were 2 to 3 times more likely to be obese than adolescents in the general population.…”

“…Low rates of physical activity put individuals at risk for obesity, heart disease, and type 2 diabetes (Centers for Disease Control and Prevention, 2021). Vigorous activity can be used to manage weight in people with Down syndrome (Ordonez et al, 2006) and lead to weight reduction. Regular physical activity can lead to healthier physical and psychosocial outcomes through body weight regulation (Garcia-Pastor et al, 2019).…”