Salivary biomarkers and cardiovascular disease: a systematic review

Gohel, Vishal; Jones, Judith A.; Wehler, Carolyn J.

doi:10.1515/cclm-2017-1018

Cited by 36 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saliva, a hypotonic multifunctional biological fluid, is an excellent source for measuring disease‐related biomolecules. The non‐invasiveness and relative ease of collection, minimal cost, ease of handling and limited expertise required make saliva a preferred screening medium for intraoral and systemic conditions, and prognostic monitoring . Whilst only 0.5% of saliva comprises electrolytes, proteins, nucleic acids and epithelial cells in health, molecules exuded from apoptotic or necrotic tumour cells result in a detectable increase in suspended molecules; some may be exclusive to malignancy whilst others reference disease‐related dysregulation.…”

Section: Saliva As a Premium Bio‐fluidmentioning

confidence: 99%

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Adeoye

Brennan

Thomson

2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350 000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐tumour heterogeneity and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or “risk‐stratifying” saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.

show abstract

Section: Saliva As a Premium Bio‐fluidmentioning

confidence: 99%

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Adeoye

Brennan

Thomson

2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Over the last decade, human saliva has attracted attention as a liquid biopsy for prevention and diagnosis of some CV diseases. [90][91][92][93] Saliva collection is non-invasive, convenient and inexpensive compared with conventional venipuncture procedure showing a promising potential as a diagnostic fluid. Salivary proteome may be useful to trace inflammatory state in CV patients.…”

Section: A Focus On Saliva and Urine Liquid Biopsy In CV Diseasesmentioning

confidence: 99%

“…Salivary proteome may be useful to trace inflammatory state in CV patients. [90][91][92][93] Miller et al 93 established that salivary MYO levels were higher within 48 hours of the onset of angina in 92 patients with AMI with respect to controls suggesting a useful role in combination with ECG for the identification of disease state. Moreover, a strong link was reported between increased levels of serum/salivary creatine phosphokinase MB and creatine phosphokinase (CPK) at onset of 12 and 24 hours of patients with AMI compared with controls.…”

Section: A Focus On Saliva and Urine Liquid Biopsy In CV Diseasesmentioning

confidence: 99%

Fluid-based assays and precision medicine of cardiovascular diseases: the ‘hope’ for Pandora’s box?

2019

View full text Add to dashboard Cite

Progresses in liquid-based assays may provide novel useful non-invasive indicators of cardiovascular (CV) diseases. By analysing circulating cells or their products in blood, saliva and urine samples, we can investigate molecular changes present at specific time points in each patient allowing sequential monitoring of disease evolution. For example, an increased number of circulating endothelial cells may be a diagnostic biomarker for diabetic nephropathy and heart failure with preserved ejection fraction. The assessment of circulating cell-free DNA (cfDNA) levels may be useful to predict severity of acute myocardial infarction, as well as diagnose heart graft rejection. Remarkably, circulating epigenetic biomarkers, including DNA methylation, histone modifications and non-coding RNAs are key pathogenic determinants of CV diseases representing putative useful biomarkers and drug targets. For example, the unmethylated FAM101A gene may specifically trace cfDNA derived from cardiomyocyte death providing a powerful diagnostic biomarker of apoptosis during ischaemia. Moreover, changes in plasma levels of circulating miR-92 may predict acute coronary syndrome onset in patients with diabetes. Now, network medicine provides a framework to analyse a huge amount of big data by describing a CV disease as a result of a chain of molecular perturbations rather than a single defect (reductionism). We outline advantages and challenges of liquid biopsy with respect to traditional tissue biopsy and summarise the main completed and ongoing clinical trials in CV diseases. Furthermore, we discuss the importance of combining fluid-based assays, big data and network medicine to improve precision medicine and personalised therapy in this field.

show abstract

“…This analyte can be detectable in saliva by means of ELISA [ 80 ] and integrated microfluidic platforms [ 81 ]. According to a recent systematic review, high salivary levels of CRP have been correlated with local inflammation (PD) and systemic inflammation [ 82 ]. At present, the most widely studied PD-related cytokines have been interleukin-1 beta and hepatocyte growth factor.…”

Section: The Salivary Proteome In the Health-illness Spectrummentioning

confidence: 99%

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

et al. 2018

View full text Add to dashboard Cite

The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.

show abstract

Salivary biomarkers and cardiovascular disease: a systematic review

Cited by 36 publications

References 24 publications

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Fluid-based assays and precision medicine of cardiovascular diseases: the ‘hope’ for Pandora’s box?

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

Contact Info

Product

Resources

About