Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis

Khijmatgar, Shahnawaz; Yong, Josh; Rübsamen, Nicole; Lorusso, Felice; Rai, Pooja; Cenzato, Niccolo; Gaffuri, Franscesca; Del Fabbro, Massimo; Tartaglia, Gianluca Martino

doi:10.1016/j.jdsr.2023.10.003

Cited by 12 publications

(3 citation statements)

References 36 publications

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“…Different body parameters reveal health status, diseases, and sub-health. Wearable biosensors can collect an extensive range of data in real time for a long time, which enables continuous health monitoring [104], early warning [105][106][107][108][109], and disease screening [110]. Figure 5 shows the significant improvement timeline.…”

Section: Applicationsmentioning

confidence: 99%

Recent Advances in Wearable Healthcare Devices: From Material to Application

Luo,

Tan,

Wen

2024

Bioengineering

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In recent years, the proliferation of wearable healthcare devices has marked a revolutionary shift in the personal health monitoring and management paradigm. These devices, ranging from fitness trackers to advanced biosensors, have not only made healthcare more accessible, but have also transformed the way individuals engage with their health data. By continuously monitoring health signs, from physical-based to biochemical-based such as heart rate and blood glucose levels, wearable technology offers insights into human health, enabling a proactive rather than a reactive approach to healthcare. This shift towards personalized health monitoring empowers individuals with the knowledge and tools to make informed decisions about their lifestyle and medical care, potentially leading to the earlier detection of health issues and more tailored treatment plans. This review presents the fabrication methods of flexible wearable healthcare devices and their applications in medical care. The potential challenges and future prospectives are also discussed.

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Section: Applicationsmentioning

confidence: 99%

Recent Advances in Wearable Healthcare Devices: From Material to Application

Luo,

Tan,

Wen

2024

Bioengineering

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“…In recent years, there has been a growing interest in utilizing salivary biomarkers as a diagnostic tool due to the advantages they offer over traditional methods ( 13 ). Saliva collection is non-invasive, easily accessible, and less stressful for animals compared to other sample collection methods such as blood or urine ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, this method is not effective in detecting pregnancy during the initial estrus cycle (21 days) after artificial insemination, leading to an increase in non-productive days (12). In recent years, there has been a growing interest in utilizing salivary biomarkers as a diagnostic tool due to the advantages they offer over traditional methods (13). Saliva collection is non-invasive, easily accessible, and less stressful for animals compared to other sample collection methods such as blood or urine (14).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Ren,

Zhang,

et al. 2024

Front. Vet. Sci.

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In an effort to enhance reproductive management and reduce non-productive periods in swine breeding, this study presents a novel, non-invasive metabolomics approach for the identification of early pregnancy biomarkers in sows. Utilizing an untargeted metabolomics approach with mass spectrometry analysis, we examined saliva samples from pregnant (n = 6) and non-pregnant control sows (n = 6, artificially inseminated with non-viable sperm). Our analysis revealed 286 differentially expressed metabolites, with 152 being up-regulated and 134 down-regulated in the pregnant group. Among these, three metabolites, namely Hyodeoxycholic acid, 2′-deoxyguanosine, and Thymidine, emerged as potential early pregnancy biomarkers. These biomarkers were further evaluated using targeted LC–MS/MS quantification and qualification, accompanied by ROC curve analysis. The study confirmed Hyodeoxycholic acid and 2′-deoxyguanosine as promising biomarkers for early pregnancy detection, offering potential for future implementation in swine production environments. This research establishes a robust theoretical foundation for the development of innovative molecular diagnostic techniques and explores new avenues for molecular genetic breeding and non-invasive diagnostics, ultimately enhancing fertility and productivity in sow herds.

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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

Liu,

Han,

Wang

et al. 2024

Environmental Toxicology

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BackgroundHead and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, particularly due to its high propensity for locoregional recurrence. Current research underscores the need to unravel the complex interactions within the tumor microenvironment. This study addresses the critical gap in understanding how FOS modulates the immune landscape in HNSCC, with a focus on its influence on fibroblast and myeloid cell dynamics.MethodsEmploying a comprehensive approach, we analyzed tissue samples from HNSCC patients and adjacent non‐cancerous tissues using bulk RNA sequencing complemented by in‐depth bioinformatics analyses, including gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, and immune infiltration assessment. A pivotal aspect of our research involved dissecting single‐cell RNA‐seq data from GSE234933 to elucidate the cell‐type‐specific expression of FOS.ResultsWe found that FOS expression varies significantly in different cell populations in the HNSCC tumor microenvironment, especially in fibroblasts and myeloid cells. This expression difference may reflect the different roles of these cells in tumor progression and their impact on the tumor microenvironment.ConclusionOur results uncover a significant correlation between FOS expression and key immune and hypoxia‐related pathways, suggesting its integral role in the tumor microenvironment. These findings not only enhance our understanding of HNSCC pathogenesis but also highlight FOS as a potential therapeutic target. This study marks a significant step towards addressing the urgent need for targeted interventions in HNSCC, particularly in the context of locoregional recurrence.

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Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis

Cited by 12 publications

References 36 publications

Recent Advances in Wearable Healthcare Devices: From Material to Application

Recent Advances in Wearable Healthcare Devices: From Material to Application

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

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