Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis

Miricescu, Daniela; Totan, Alexandra; Calenic, Bogdan; Mocanu, Brânduşa; Didilescu, Andreea Cristiana; Mohora, Maria; Spinu, Tudor; Greabu, Maria

doi:10.3109/00016357.2013.795659

Cited by 143 publications

(175 citation statements)

References 38 publications

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“…In our studies salivary levels of uric acid were signifi cantly decreased in chronic periodontitis patients as compared to controls. At the same time uric acid was found in a negative correlation with CTX I and MMP-8 both markers of bone resorption [ 55 ]. This fi nding shows that saliva refl ects the associations that can exist between decreased concentrations of antioxidant mechanisms and development of periodontal disease.…”

Section: Saliva: Antioxidant Defense Systems and Oxidative Stress Biomentioning

confidence: 52%

“…TAC is signifi cantly decreased in smokers, patients with periodontal affections, patients with oral cancer or diabetes. In a recent study our group demonstrated that saliva from chronic periodontitis patients had a decreased TAC value compared to normal controls [ 55 ]. However, TAC did not correlate with other analyzed periodontal biomarkers.…”

Section: Saliva: Antioxidant Defense Systems and Oxidative Stress Biomentioning

confidence: 99%

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Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases

Greabu

Calenic

2013

Studies on Periodontal Disease

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Section: Saliva: Antioxidant Defense Systems and Oxidative Stress Biomentioning

confidence: 52%

Section: Saliva: Antioxidant Defense Systems and Oxidative Stress Biomentioning

confidence: 99%

Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases

Greabu

Calenic

2013

Studies on Periodontal Disease

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“…A correlation between salivary MDA levels and C-terminal telopeptide of type I collagen, a biomarker for bone loss, was also reported. 46 These findings point to a possible systemic low AO expression in CP, but the relative contribution of oPMNs to low oral AO capacity may be critical for disease progression.…”

Section: Nrf2 Down-regulation In Periodontitismentioning

confidence: 93%

Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis

Sima

Aboodi

Lakschevitz

et al. 2016

The American Journal of Pathology

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The balance between reactive oxygen species and antioxidants plays an important role in periodontal health. We previously demonstrated that high reactive oxygen species production by oral polymorphonuclear neutrophils (oPMNs) in chronic periodontitis (CP) refractory to conventional therapy is associated with severe destruction of periodontium. Herein, we show that inhibition of antioxidant production through down-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in oPMN, despite enhanced recruitment in the oral cavity, is associated with severe CP. Twenty-four genes in the Nrf2-mediated oxidative stress response pathway were down-regulated in PMNs of diseased patients. Downstream of Nrf2, levels of oPMN superoxide dismutase 1 and catalase were decreased in severe CP, despite increased recruitment. Nrf2 À/À mice had more severe loss of periodontium in response to periodontitis-inducing subgingival ligatures compared with wild-types. Levels of 8-hydroxydeoxyguanosine were increased in periodontal lesions of Nrf2 À/À mice, indicating high oxidative damage. We report, for the first time, Nrf2 pathway down-regulation in oPMNs of patients with severe CP. PMNs of CP patients may be primed for low antioxidant response in the context of high recruitment in the oral cavity, resulting in increased oxidative tissue damage. (Am J Pathol 2016 http://dx

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“…Miricescu et al analyzed the relationship between oxidative stress and alveolar bone loss in chronic periodontitis (32). Significant positive correlations were observed between osteocalcin and clinical parameters of periodontal disease.…”

Section: Markers Of Alveolar Bone Lossmentioning

confidence: 99%

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

Rajapriya

Saravanan

et al. 2014

ADUM

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Aim: This review intends to provide a highlight on the potential application of salivary proteomics in periodontal diagnosis and attempts to throw light on the emerging salivary diagnostic tools for periodontal disease detection. Background: Clinical parameters for detection of periodontitis such as probing depth, attachment level, bleeding on probing, plaque index, and radiographic assessment of alveolar bone loss provide information on the severity of periodontitis, but they do not measure disease activity. Ideally, development and application of rapid and simple diagnostic tests based on host salivary or immune factors may facilitate early detection of patients at risk for periodontal diseases, allow appropriate intervention, decrease the need for more aggressive treatment and improve the response to periodontal therapy. Results: Studies have shown that saliva could be used as a diagnostic fluid as it is one of the inexpensive, noninvasive and easy-to-use diagnostic methods. Salivary constituents that have been studied as potential diagnostic biomarkers for periodontal disease includes locally produced proteins of host and bacterial origin, genetic/genomic biomarkers such as DNA and mRNA of host origin, bacteria and bacterial products, ions, steroid hormones and volatile compounds. Conclusion: Periodontal oral diagnostic devices will enable screening of large populations, more quickly and effectively. Use of salivary biomarkers to sample large populations will help to identify at-risk groups more effectively and increase access to treatment for those most at need, thereby, improving public health.

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Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis

Abstract: Important oxidative stress associated with alveolar bone loss biomarkers can be detected in saliva of patients with periodontal disease.

Cited by 143 publications

References 38 publications

Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases

Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases

Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

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