Salivary Bisphenol-A Levels due to Dental Sealant/Resin: A Case-Control Study in Korean Children

Han, Dong-Hun; Kim, Minji; Jun, Eun-Joo; Kim, Jin‐Bom

doi:10.3346/jkms.2012.27.9.1098

Cited by 35 publications

(26 citation statements)

References 33 publications

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“…22 The findings of two retrospective studies in Korean children provided support for the degradation hypothesis, showing that greater prevalent exposure to bis-GMA–based dental sealants or composites was associated with statistically significantly higher BPA concentrations in saliva and urine. 23,24 In contrast, Kingman and colleagues 7 found no association between number of preexisting composites and urinary BPA concentrations in adults, which suggests that degradation of composites may not pose a problem. Our findings do not confirm or refute the possibility that degradation of dental sealants or restorations increases BPA concentrations.…”

Section: Discussionmentioning

confidence: 96%

Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey

McKinney¹,

Rue²,

Sathyanarayana³

et al. 2014

The Journal of the American Dental Association

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Background Resin-based dental sealants and composites contain bisphenol A-glycidyl methacrylate, a bisphenol A (BPA) derivative. The authors hypothesized that a greater number of sealants or restorations would be associated with higher urinary BPA concentrations. Methods The authors examined urinary BPA measurements (in nanograms per milliliter) and oral examination data for 1,001 children aged 6 to 19 years from the dataset of the 2003-2004 National Health Examination and Nutrition Survey (NHANES). They categorized children into four groups according to number of occlusal sealants and number of restorations, separately. They estimated associations by using unadjusted and adjusted tobit regression models. Results The lowest quartile of BPA concentrations ranged from 0.3 ng/mL to 1.9 ng/mL, whereas the highest quartile ranged from 7.3 ng/mL to 149 ng/mL. In adjusted analysis, children with seven to 16 sealants had geometric mean BPA concentrations 25 percent higher than those of children with no sealants (95 percent confidence interval [CI], −14 percent to 82 percent; P = .23). In adjusted analyses, children with seven to 42 restorations had geometric mean BPA concentrations 20 percent higher than those of children with no restorations (95 percent CI, −6 percent to 53 percent; P = .13). Neither of these adjusted estimates was statistically significant. Conclusions Though the findings were in the direction hypothesized, the authors did not observe a statistically significant association between a greater number of sealants or restorations and higher urinary BPA concentrations. Additional studies are needed to determine the extent of oral and systemic exposure to BPA from resin-based dental restorative materials over time. Practical Implications Dentists should follow this issue carefully as it develops and as the body of evidence grows. There is insufficient evidence to change practice at this time.

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Section: Discussionmentioning

confidence: 96%

Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey

McKinney¹,

Rue²,

Sathyanarayana³

et al. 2014

The Journal of the American Dental Association

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“…BPA was elevated significantly from baseline measurements before sealant (range 0.07 to 6.00 ng/mL) at all post-treatment time points for both groups, with main peak amounts of 3.98 and 9.08 ng/mL for the one-occlusal sealant group and the four occlusal-sealants group, respectively. More recently, Han et al (2012) made a survey including 62 children serving as control, without restorations in the oral cavities, and 62 children treated with more than 4 sealants. A possible relationship was found: BPA level of control was 0.40 μg/L, whereas BPA levels in saliva of treated children was 0.92 μg/L after controlling for confounders.…”

Section: Dental Materialsmentioning

confidence: 99%

The safety of the use of bisphenol A in medical devices

Testai

Hartemann

Rodrı́guez-Farré

et al. 2016

Regulatory Toxicology and Pharmacology

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About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCENIHR This Committee deals with questions related to emerging or newly identified health and environmental risks and to broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk assessment bodies. Examples of potential areas of activity include potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices including those incorporating substances of animal and/or human origin, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields (from mobile phones, transmitters and electronically controlled home environments), and methodologies for assessing new risks. It may also be invited to address risks related to public health determinants and non-transmissible diseases.

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“…Among these chemicals, bio‐based isosorbide (1,4:3,6‐dianhydroglucitol), which is obtained by hydrogenation of glucose followed by dehydration of sorbitol, has attracted much attention as an alternative to bisphenol A (BPA) because of its rigidity and transparency . BPA is still widely used for a variety of chemical applications even though it is an endocrine‐disrupting chemical (EDC) . BPA is a key precursor of most photo‐curable materials, ranging from encapsulants of electronic devices to dental sealants .…”

Section: Introductionmentioning

confidence: 99%

Photo‐curing behaviors of bio‐based isosorbide dimethacrylate by irradiation of light‐emitting diodes and the physical properties of its photo‐cured materials

Kim

Cho

Shin

et al. 2015

J of Applied Polymer Sci

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Bio-based isosorbide (1,4:3,6-dianhydroglucitol), which was obtained from biomass-derived carbohydrates, has recently attracted much attention as an alternative to bisphenol A (BPA) because of its rigidity and transparency. BPA is still widely used for a variety of chemical applications even though it is known to be an endocrine-disrupting chemical. BPA is a key precursor to most photo-curable materials ranging from encapsulants of electronic devices to dental sealants. In this study, photo-curable isosorbide dimethacrylate (ISDM) was synthesized from bio-based isosorbide as a substitute for BPA, and the photo-curing behaviors of ISDM by irradiation with light-emitting diode (LED) light were investigated. The photo-curing conversion and rates of ISDM formation were determined based on the change in the peak corresponding to the double bond within the methacrylate groups using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. The effects of initiators and the wavelength of LED light on the photo-curing conversion and rates of ISDM formation were examined, and a comparative study was carried out with 2,2-bis[4(2hydroxy-3-methacryloyloxy-propyloxy)phenylpropane] (Bis-GMA), which is a photo-curing material bearing a BPA moiety. In addition, the mechanical properties, such as surface hardness, adhesion strength, and transparency, after photo-curing of ISDM were evaluated.

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Salivary Bisphenol-A Levels due to Dental Sealant/Resin: A Case-Control Study in Korean Children

Cited by 35 publications

References 33 publications

Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey

Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey

The safety of the use of bisphenol A in medical devices

Photo‐curing behaviors of bio‐based isosorbide dimethacrylate by irradiation of light‐emitting diodes and the physical properties of its photo‐cured materials

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