Salivary carcinomas with papillae: Cytology and histology analysis of polymorphous low-grade adenocarcinoma and papillary cystadenocarcinoma

Klijanienko, Jerzy; Vielh, Philippe

doi:10.1002/(sici)1097-0339(199810)19:4<244::aid-dc3>3.0.co;2-a

Cited by 48 publications

(24 citation statements)

References 30 publications

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“…(Table I). [9][10][11][12] The background shows mucin in varying proportions with histiocytes. In contrast, cases with a scant cellular smear have also been seen, similar to this case; however, there has been no description of a ball-like cluster in previous reports.…”

Section: Discussionmentioning

confidence: 99%

“…3 Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis of benign lesions from malignant tumors with cystic growth, such as the papillary-cystic variant of acinic cell carcinoma (ACC-PCV), a low-grade mucoepidermoid carcinoma or cystadenoma, but there have been few reports regarding the cytological features of cystadenocarcinoma in fine-needle aspiration cytology (FNAC). [9][10][11][12] We report a case of cystadenocarcinoma arising from the parotid gland of a young man, for whom the preoperative cytological diagnosis was difficult, and discuss the differential diagnoses from a salivary gland lesion with prominent cystic structures.…”

Section: Abstract: Parotid Aspiration Cytology; Cystadenocarcinoma; mentioning

confidence: 99%

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Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Kawahara

Harada

Mihashi

et al. 2010

Diagnostic Cytopathology

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Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors. Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth. We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 x 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these findings on FNAC. Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue. The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells. There was neither a definite double-layered arrangement in cystic ducts and solid islands nor histological findings characteristic of the papillary-cystic or follicular pattern of ACC-PCV. As tumor cells with a small vacuolated, soap-bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC-PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid.

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Section: Discussionmentioning

confidence: 99%

Section: Abstract: Parotid Aspiration Cytology; Cystadenocarcinoma; mentioning

confidence: 99%

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Kawahara

Harada

Mihashi

et al. 2010

Diagnostic Cytopathology

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“…The differential diagnosis of intraductal carcinoma of the salivary glands on FNAB includes a plethora of primary and metastatic neoplasms to the salivary glands, with oncocytic changes such as salivary gland cystadenocarcinoma (Figure A‐F), MASC, the papillary cystic variant of ACC, MEC (Figure A‐F), and metastatic breast carcinoma with apocrine features (Figure A‐F), among others. FNAB of salivary gland cystadenocarcinomas (Figure A‐D) is characterized by pseudo‐papillary sheets and clusters of medium to large‐sized epithelial cells, with abundant granular eosinophilic cytoplasm, round central nuclei, and prominent nucleoli . Histopathologic examination reveals (Figure E,F) prominent cystic dilation of glands, lined by eosinophilic cuboidal cells growing in fronds, and creating a pseudo‐papillary overall architecture .…”

Section: Discussionmentioning

confidence: 99%

“…FNAB of salivary gland cystadenocarcinomas (Figure A‐D) demonstrates pseudo‐papillary structures formed by medium to large‐sized epithelial cells, with abundant granular and vacuolated eosinophilic cytoplasm, round central mild to moderately atypical nuclei and prominent nucleoli, in a background of cystic debris . These features are typically not sufficient to differentiate between a benign and a malignant salivary gland neoplasm, placing CAC in the category of “neoplasm with uncertain malignant potential” upon cytopathology examination …”

Section: Discussionmentioning

confidence: 99%

Cytopathology approach to rare salivary gland lesions with oncocytic features

Hussein

Khader

2019

Diagnostic Cytopathology

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Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. Fine needle aspiration is usually the initial approach in the management of these lesions, whether they represent neoplastic or non‐neoplastic processes. Owing to the limited material present upon cytopathologic examination, knowledge of variants and subtypes of various oncocytic lesions that can occur in this area is of major importance to provide the most accurate interpretation to the patients and clinicians. In this article, we selected rare lesions of the salivary glands that may exhibit oncocytic changes, and provided a brief discussion of each one of them, with emphasis on challenges in navigating the differential diagnosis that these cases may pose, from the cytopathology standpoint.

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“…[8] In the literature, the lesion most often confused with cystadenocarcinomas are Warthin's tumor or salivary gland cysts. [9] However, Warthin tumors show monolayered sheets of oncocytes and many lymphocytes in a background of amorphous, granular debris. Salivary gland cysts are less cellular and show some mildly atypical epithelial cells and macrophages in a mucoid background.…”

Section: Discussionmentioning

confidence: 99%

Papillary cystadenocarcinoma of submandibular salivary gland: A rare case report

2010

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Papillary cystadenocarcinoma is an extremely rare malignant neoplasm characterized by cysts and papillary endophytic projections. It was first defined in 1991 by World Health organization as a separate entity. Major locations of this neoplasm are the parotid gland, the sublingual gland, and minor salivary glands, while occurrence in the submandibular gland is extremely rare. We present a case of papillary cystadenocarinoma arising from the submandibular gland in a 67-year-old male patient. Further, we have discussed the cytological and histopathological features of this rare entity and reviewed the current literature.

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Salivary carcinomas with papillae: Cytology and histology analysis of polymorphous low-grade adenocarcinoma and papillary cystadenocarcinoma

Cited by 48 publications

References 30 publications

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Cytopathology approach to rare salivary gland lesions with oncocytic features

Papillary cystadenocarcinoma of submandibular salivary gland: A rare case report

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