Salivary Components of Treated Cancer Patients and Patients With Precancerous Lesions

Krasteva, Asya; Kisselova, Angelina

doi:10.5272/jimab.14-2-2008.41

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…Salivary protein composition reflects the cellular signal interactions resulting from stress as well as various environmental influences [29]. In cancer and pre-cancer patients, the salivary protein concentration increases [30]. In the present study, salivary proteins increased in OSF group and the increase positively correlated with progressive clinical grades based on mouth opening, fibrotic bands and histological grades.…”

Section: Discussionsupporting

confidence: 57%

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

et al. 2017

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This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Unstimulated saliva from both control and OSF patients were analysed for oxidative markers like lipid peroxides (LPO), non-enzymic antioxidants [reduced glutathione (GSH), vitamin A, vitamin E, vitamin C] and enzymatic antioxidants [glutathione peroxidase (GPx), superoxide dismutase (SOD)] and correlated with different stages and grades. Total salivary protein and LPO were significantly increased in OSF group with no significant change in the levels of GSH compared to controls. In OSF patients, a significant decrease in the levels of vitamins A, C and E was observed. The activities of salivary SOD and GPx were significantly decreased in OSF patients compared to controls. These changes significantly correlated with the increasing and differing grades of OSF that reflects increased oxidative stress with the progress of OSF.

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Section: Discussionsupporting

confidence: 57%

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

et al. 2017

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“…This finding was consistent with Brown AM et al .,[ 19 ] Iglehart JD et al .,[ 25 ] Scully C,[ 21 ] Krasteva A et al . [ 26 ] and Patidar KA et al . [ 27 ] Lee YN,[ 28 ] Krasteva A et al .…”

Section: Discussionmentioning

confidence: 99%

A study to estimate the serum IgA and salivary IgA levels in patients with oral leukoplakia and oral squamous cell carcinoma

Yadav,

Shetty,

Dave

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Context: The increasing death rate because of oral cancer is mainly due to its late diagnosis. Tumour markers are often detected in abnormal amounts in blood, urine or saliva of patients with certain types of cancer. Diagnosing cancer through human saliva has advantages such as low invasiveness, minimum cost and easy sample collection. We have used serum immunoglobulin A (IgA) and salivary IgA for our present study. Aims: The aim of present study was to estimate serum and salivary IgA levels in oral leukoplakia and oral squamous cell carcinoma (OSCC) patients. Settings and Design: The study included 40 patients; 10 in the control group, 15 cases with oral leukoplakia and 15 cases with OSCC. Methods and Material: The blood samples and saliva were taken from clinically diagnosed oral leukoplakia and OSCC patients and were tested for IgA levels. Statistical analysis used: The data were analysed using SPSS 16.0. The mean values were compared between the groups by using analysis of variance (ANOVA) followed by post-hoc test for group-wise comparison. P value ≤ 0.05 was considered significant. Results: It was observed that the comparison of levels of serum IgA in control and leukoplakia group; control and OSCC group; leukoplakia and OSCC group were found to be statistically significant. Also, comparison between the levels of salivary IgA in control and OSCC group was found to be statistically significant. Conclusion: It is suggested that the serum and salivary IgA levels could be a better adjuvant diagnostic marker along with routine markers in patients with premalignant and malignant lesions.

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“…Different authors have reported varying results on the concentrations of salivary IgA in patients with oral squamous cell carcinoma. Some authors [15,16] reported elevated salivary IgA in subjects with oral squamous cell carcinoma compared with healthy controls. The increased titers of salivary IgA observed in their studies were attributed to a possible local antibody response to tumor because transudation of serum IgA to saliva is responsible for only a minute amount of total salivary IgA.…”

Section: Discussionmentioning

confidence: 99%

Salivary and Serum IgA Evaluation of Patients with Oro-Facial Squamous Cell Carcinoma

Lasisi¹,

Yusuf²,

Lasisi³

et al. 2013

IJOHNS

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Objective: To evaluate salivary and serum levels of Immunoglobulin A (IgA) in patients with oro-facial squamous cell carcinoma. Methods: This is a cross sectional study. Patients with oro-facial squamous cell carcinoma attending the Oral Pathology and Radiotherapy clinics of the University College Hospital, Ibadan, Nigeria were included. Seventy subjects comprising 22 patients with untreated OSCC, 18 patients with OSCC receiving treatment and 30 healthy, age and gender matched individuals were included. Serum and salivary samples from the participants were analysed for IgA levels using ELISA technique. Results: The mean value of serum IgA in OSCC patients receiving treatment was significantly lower compared with healthy controls (p = 0.03), while no significant difference was observed comparing untreated OSCC patients with treated and healthy controls. The salivary IgA levels did not show any significant difference between the three groups (p = 0.73). Also, there was no correlation between serum and salivary levels of IgA among the subjects. Conclusions: Serum IgA appeared to be better index than salivary IgA levels in monitoring response to treatment in patients with oro-facial carcinoma.

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Salivary Components of Treated Cancer Patients and Patients With Precancerous Lesions

Cited by 4 publications

References 13 publications

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

A study to estimate the serum IgA and salivary IgA levels in patients with oral leukoplakia and oral squamous cell carcinoma

Salivary and Serum IgA Evaluation of Patients with Oro-Facial Squamous Cell Carcinoma

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