Salivary cortisol and psychopathy dimensions in detained antisocial adolescents

Feilhauer, Johanna; Cima, Maaike; Korebrits, Andries; Nicolson, Nancy A.

doi:10.1016/j.psyneuen.2013.01.005

Cited by 38 publications

(28 citation statements)

References 50 publications

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“…Both clusters are comprised of young people with ASPD features and numerous comorbidities, including impulsivity, aggressiveness, and SUD, psychiatric history of previous consultations and hospitalizations, and an extensive criminal history. In keeping with previous findings,31,73 both clusters are associated with low levels of cortisol. However, while cluster 4 displays high testosterone levels and a high testosterone–cortisol ratio, cluster 2 displays low scores on these measures, suggesting clinical and etiological differences between the groups.…”

Section: Discussionsupporting

confidence: 92%

Male Inmate Profiles and Their Biological Correlates

et al. 2014

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Objective:Borderline and antisocial personality disorders (PDs) share common clinical features (impulsivity, aggressiveness, substance use disorders [SUDs], and suicidal behaviours) that are greatly overrepresented in prison populations. These disorders have been associated biologically with testosterone and cortisol levels. However, the associations are ambiguous and the subject of controversy, perhaps because these heterogeneous disorders have been addressed as unitary constructs. A consideration of profiles of people, rather than of exclusive diagnoses, might yield clearer relationships.Methods:In our study, multiple correspondence analysis and cluster analysis were employed to identify subgroups among 545 newly convicted inmates. The groups were then compared in terms of clinical features and biological markers, including levels of cortisol, testosterone, estradiol, progesterone, and sulfoconjugated dehydroepiandrosterone (DHEA-S).Results:Four clusters with differing psychiatric, criminal, and biological profiles emerged. Clinically, one group had intermediate scores for each of the tested clinical features. Another group comprised people with little comorbidity. Two others displayed severe impulsivity, PD, and SUD. Biologically, cortisol levels were lowest in the last 2 groups and highest in the group with less comorbidity. In keeping with previous findings reported in the literature, testosterone was higher in a younger population with severe psychiatric symptoms. However, some apparently comparable behavioural outcomes were found to be related to distinct biological profiles. No differences were observed for estradiol, progesterone, or DHEA-S levels.Conclusions:The results not only confirm the importance of biological markers in the study of personality features but also demonstrate the need to consider the role of comorbidities and steroid coregulation.

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Section: Discussionsupporting

confidence: 92%

Male Inmate Profiles and Their Biological Correlates

et al. 2014

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“…In general, studies have found lower levels of cortisol reactivity to stressors in children and adolescents with aggression problems [9, 10, 29, 37, 44, 45]. Of particular, interest is that low cortisol reactivity to stress was found to be predictive of higher levels of aggressive behavior in school-aged boys in treatment for ODD/CD, indicating that cortisol non-responders to stress are more persistent in aggressive behavior than cortisol stress responders [41].…”

Section: Introductionmentioning

confidence: 99%

Neurobiological stress responses predict aggression in boys with oppositional defiant disorder/conduct disorder: a 1-year follow-up intervention study

Schoorl

Rijn

Wied

et al. 2017

Eur Child Adolesc Psychiatry

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To improve outcome for children with antisocial and aggressive behavior, it is important to know which individual characteristics contribute to reductions in problem behavior. The predictive value of a parent training (Parent Management Training Oregon; PMTO), parenting practices (monitoring, discipline, and punishment), and child neurobiological function (heart rate, cortisol) on the course of aggression was investigated. 64 boys with oppositional defiant disorder or conduct disorder (8–12 years) participated; parents of 22 boys took part in PMTO. All data were collected before the start of the PMTO, and aggression ratings were collected three times, before PMTO, and at 6 and 12 month follow-up. Parent training predicted a decline in aggression at 6 and 12 months. Child neurobiological variables, i.e., higher cortisol stress reactivity and better cortisol recovery, also predicted a decline in aggression at 6 and 12 months. Heart rate and parenting practices were not related to the course of aggression. These results indicate that child neurobiological factors can predict persistence or reduction of aggression in boys with ODD/CD, and have unique prognostic value on top of the parent training effects.

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“…The HPA axis has also recently been investigated in children with externalizing problems. [50][51][52][53][54][55] There is a body of evidence demonstrating an association between altered HPA axis reactivity and aggressive behavior. Several studies have shown reduced cortisol concentrations and a blunted HPA axis reactivity to stress.…”

Section: Discussionmentioning

confidence: 99%

Internalizing and externalizing problems in obese children and adolescents: associations with daily salivary cortisol concentrations

Pervanidou

Bastaki

Chouliaras

et al. 2015

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OBJECTIVE: Pediatric obesity commonly co-exists with emotional and behavioral disorders, while disturbed cortisol concentrations have been reported in both obese and chronically stressed individuals with anxiety and/or depression. We investigated the prevalence of internalizing and externalizing problems, reported by both parents and children, in a clinical population of obese children (OC) compared to normal-weight children. We examined the role of cortisol as a potential mediator between obesity and such problems. DESIGN: We compared 110 obese with 31 normal-weight children. The Greek version of the child behavior checklist (CBCL) and the youth self-report (YSR) were used and salivary cortisol was determined serially five times a day. RESULTS: T-scores of internalizing problems (anxiety/depression, social withdrawal, somatic complains) reported by both children (49.3±12.3 vs. 43.2±9.1) and mothers (60.6±11.3 vs. 50.6±10.4) were significantly higher (p=0.03 and p<0.001, respectively) in the obese than in the lean children. Externalizing problems (delinquency, rule-breaking behaviors) reported only by mothers were significantly higher in the OC (57.2 ±10.5 vs. 48.2±13.3, p=0.003). The cortisol area under the curve (AUC) was significantly smaller (p=0.03) in the OC than in the controls; however, a cortisol correlation with internalizing/externalizing symptoms was not observed. CONCLUSIONS: There is a high prevalence of internalizing and externalizing problems in a clinical population of OC. A mediation effect of cortisol in the relation between internalizing/ externalizing problems and obesity could not be supported.

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Salivary cortisol and psychopathy dimensions in detained antisocial adolescents

Cited by 38 publications

References 50 publications

Male Inmate Profiles and Their Biological Correlates

Male Inmate Profiles and Their Biological Correlates

Neurobiological stress responses predict aggression in boys with oppositional defiant disorder/conduct disorder: a 1-year follow-up intervention study

Internalizing and externalizing problems in obese children and adolescents: associations with daily salivary cortisol concentrations

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