Salivary Cortisol Levels in Patients with Oral Lichen Planus—A Pilot Case-Control Study

Abstract

It is known that cortisol level increases in stress situations. The aim of the study was to measure the levels of salivary cortisol in patients with oral lichen planus (OLP) and healthy controls. This was a case-control pilot study which included seven patients with reticular (non-symptomatic) OLP, eight patients with atrophic/erosive (symptomatic) OLP, and nine healthy controls. We hypothesized that patients with an atrophic/erosive type of OLP have higher levels of cortisol compared to patients with the reticular type of OLP and healthy controls. In each participant, unstimulated saliva was collected in order to determine cortisol levels by using commercially available ELISA kit. Our results have shown no differences between levels of salivary cortisol in OLP patients and healthy controls. We can conclude that further research with a larger number of OLP patients is needed to determine the correlation between OLP and stress.

Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial

“…The advantages of our study are that, to our knowledge, this is the first study measuring salivary cortisol levels in patients with BMS before and after LLLT. The limitations of the study refer to cortisol measurement that may be affected by wake up-time and it cannot be influenced by the researcher (34).…”

“…Prednost naše studije jest da je, prema našem znanju, to prva studija koja mjeri razinu kortizola u slini bolesnika sa SPU-om prije liječenja niskoenergijskim laserom i nakon toga postupka. Ograničenje studije odnosi se na mjerenje kortizola na koje može utjecati vrijeme buđenja, a na koje istraživač ne može utjecati (34).…”

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

“…Lichen planus is a chronic inflammatory disease that effects the skin and oral mucosa (1). It affects ~1-2% of people over 40 years worldwide (2).…”

Use of computerized anesthesia in children's anxiety and pain perception during dental care: protocol for a randomized clinical trial

“…In all, there will be 186 samples, two collections per patient: the first performed 10 minutes before the procedure, and the second 10 minutes after its completion. Each salivary sample will be labeled, centrifuged for 10 minutes at 3200 RPM, and stored at -20° C until additional biochemical analysis for Cortisol, which will be measured using an Enzyme Immunoassay kit (LUCIO-Medical ELISA Salivary Cortisol Kit, Nal von Minden, Germany), as recommended by other studies in the literature (Gadicherla et al, 2018;Skrinjar et al, 2019;Zhu et al, 2019).…”