Salivary cytokines as a minimally‐invasive measure of immune functioning in young children: Correlates of individual differences and sensitivity to laboratory stress

Riis, Jenna L.; Granger, Douglas A.; DiPietro, Janet A.; Bandeen‐Roche, Karen; Johnson, Sara B.

doi:10.1002/dev.21271

Cited by 54 publications

(55 citation statements)

References 75 publications

(123 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study used data from the Fetus to Five study, supplemented with data collected from a community sample (DiPietro et al, 2010; Riis et al, 2015). …”

Section: Methodsmentioning

confidence: 99%

“…Mother-child pairs were recruited in 2011–2013 as detailed previously (DiPietro et al, 2010; Riis et al, 2015). Approximately a third of the sample (58 pairs) was recruited from mothers who participated in a fetal development study in 2006–2007.…”

Section: Methodsmentioning

confidence: 99%

“…The Not Sharing Game also elicits an increase in salivary cortisol in young children (Spinrad et al, 2009). Detailed descriptions of the tasks were previously published (Riis et al, 2015). …”

Section: Methodsmentioning

confidence: 99%

“…In contrast, saliva collection is minimally-invasive, low-cost and generally more socially acceptable (Djuric et al, 2008; Marques, Silverman, & Sternberg, 2010). Research focused on salivary immune markers in healthy young children is limited; however, there is a growing body of literature, especially examining interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) (El-Sheikh, Buckhalt, Granger, Erath, & Acebo, 2007; Keller, El-Sheikh, Vaughn, & Granger, 2010; Riis, Granger, DiPietro, Bandeen-Roche, & Johnson, 2015). These salivary inflammatory biomarkers open up new opportunities to gain a better understanding of NEI functioning in children and the role caregivers play in moderating stress-related damage within the NEI network.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal distress and child neuroendocrine and immune regulation

Riis

Granger

Minkovitz

et al. 2016

Social Science & Medicine

Self Cite

View full text Add to dashboard Cite

Rationale Neuroendocrine-immune regulation is essential for maintaining health. Early-life adversity may cause dysregulation in the neuroendocrine-immune network through repeated activation of the stress response, thereby increasing disease risk. Objective This paper examined the extent to which maternal psychological well-being moderates neuroendocrine-immune relations in children. Methods We used data from a laboratory-based study of mothers and their five-year old children (n=125 mother-child pairs) conducted from 2011–2013 in Baltimore, Maryland. Child saliva was assayed for markers of immune function (i.e., cytokines: interleukin [IL]-1β, IL-6, IL-8, tumor necrosis factor alpha [TNF-α]) and hypothalamic-pituitary-adrenal activity (i.e., cortisol). A composite score for depressive symptoms, anxiety, and parenting stress characterized maternal psychological distress. Multilevel mixed models examined the relationship between maternal psychological well-being and child neuroendocrine-immune relations. Results Significant cytokine × maternal distress interactions indicated that as maternal distress increased, expected inverse cytokine-cortisol relations within children became weaker for IL-1β, IL-6, and TNF-α. Sex-stratified models revealed that these interactions were only significant among girls. Among boys, there were inverse cytokine-cortisol relations for all cytokines, and, while in the same direction as observed among girls, the cytokine × maternal distress interactions were non-significant. Conclusion The findings suggest that maternal distress is associated with child neuroendocrine-immune relations in saliva and may alter the sensitivity of inflammatory immune processes to cortisol's inhibitory effects. This desensitization may place the child at risk for inflammatory diseases. The findings support efforts for the early detection and treatment of at-risk mothers to protect maternal and child health and well-being.

show abstract

“…This study used data from the Fetus to Five study, supplemented with data collected from a community sample (DiPietro et al, 2010; Riis et al, 2015). …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal distress and child neuroendocrine and immune regulation

Riis

Granger

Minkovitz

et al. 2016

Social Science & Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Two maternal and 2 infant values were Winsorized. 25 All skewness statistics were below 1.0 after the transformations. …”

Section: Missing Data and Transformationsmentioning

confidence: 99%

Maternal and Infant Secretory Immunoglobulin A across the Peripartum Period

Hibel

Schiltz

2015

J Hum Lact

View full text Add to dashboard Cite

show abstract

Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression

et al. 2020

View full text Add to dashboard Cite

Background: Depression rates increase markedly for girls across the adolescent transition, but the social-environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which posits that individuals who mount stronger inflammatory responses to social stress should exhibit greater increases in depressive symptoms following interpersonal life stress exposure than those who mount weaker inflammatory responses to such stress.Method: Participants were 116 adolescent girls (M age = 14.71) at risk for psychopathology, defined as having a history of mental health concerns (e.g., psychiatric treatment, significant symptoms) over the past 2 years. At baseline, we characterized their inflammatory reactivity to social stress by quantifying their salivary proinflammatory cytokine responses to a laboratory-based social stressor.Then, 9 months later, we assessed the interpersonal and noninterpersonal stressful life events that they experienced over the prior 9 months using an interview-based measure of life stress.Results: As hypothesized, greater interpersonal life stress exposure was associated with significant increases in depression over time, but only for girls exhibiting stronger salivary tumor necrosis factor-α and interleukin-1β reactivity to social stress. In contrast, noninterpersonal stress exposure was unrelated to changes in depression longitudinally, both alone and when combined with youths' cytokine reactivity scores.

show abstract

Salivary cytokines as a minimally‐invasive measure of immune functioning in young children: Correlates of individual differences and sensitivity to laboratory stress

Cited by 54 publications

References 75 publications

Maternal distress and child neuroendocrine and immune regulation

Maternal distress and child neuroendocrine and immune regulation

Maternal and Infant Secretory Immunoglobulin A across the Peripartum Period

Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression

Contact Info

Product

Resources

About