Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes

Izawa, Shuhei; Sugaya, Nagisa; Shirotsuki, Kentaro; Yamada, Kosuke; Ogawa, Namiko; Ouchi, Yuko; Nagano, Yuichiro; Suzuki, Katsuhiko; Nomura, Shinobu

doi:10.1016/j.biopsycho.2008.07.003

Cited by 98 publications

(92 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because DHEAS levels are also more stable and show no diurnal variation (Kroboth et al, 1999), they are often preferred in studies on long term effects of stress. Studies on acute stress, on the other hand, often assess DHEA, since DHEAS serves as a reservoir for DHEA biosynthesis and DHEA rather than DHEAS is expected to respond to acute psychosocial stress (Izawa et al, 2008;Morgan et al, 2004;Oberbeck et al, 1998;Pico-Alfonso et al, 2004;Shirotsuki et al, 2009). However, in a recent study, although the response of DHEA was more pronounced, both DHEA and DHEAS were found to increase in response to acute psychosocial stress (Lennartsson et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

View full text Add to dashboard Cite

SummaryBackground: Decreased activation of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress is suspected to be a vulnerability factor for posttraumatic stress disorder (PTSD). Previous studies showed inconsistent findings regarding the role of cortisol in predicting PTSD. In addition, no prospective studies have examined the role of dehydroepiandrosterone (DHEA), or its sulfate form DHEAS, and the cortisol-to-DHEA(S) ratio in predicting PTSD. In this study, we tested whether acute plasma cortisol, DHEAS and the cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks and 6 months post-trauma. Methods: Blood samples of 397 adult level-1 trauma center patients, taken at the trauma resuscitation room within hours after the injury, were analyzed for cortisol and DHEAS levels. PTSD symptoms were assessed at 6 weeks and 6 months post-trauma with the Clinician Administered PTSD Scale. Results: Multivariate linear regression analyses showed that lower cortisol predicted PTSD symptoms at both 6 weeks and 6 months, controlling for age, gender, time of blood sampling, injury, trauma history, and admission to intensive care. Higher DHEAS and a smaller cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks, but not after controlling for the same variables, and not at 6 months. Conclusions: Our study provides important new evidence on the crucial role of the HPA-axis in response to trauma by showing that acute cortisol and DHEAS levels predict PTSD symptoms in survivors of recent trauma. #

show abstract

Section: Introductionmentioning

confidence: 98%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…DHEA is the most important androgen secreted by the adrenal cortex and is a precursor for sex steroids (Izawa et al, 2008). As is the case with cortisol, the main secretagogue for DHEA is ACTH (Izawa et al, 2008).…”

Section: Salivary Dhea As a Marker For Stressmentioning

confidence: 99%

“…As is the case with cortisol, the main secretagogue for DHEA is ACTH (Izawa et al, 2008). Salivary DHEA levels have been found to respond to physical stress and some believe that it is a better marker than salivary testosterone for measuring the anabolic hormonal response to exercise in both males and females (Papacosta et al, 2011).…”

Section: Salivary Dhea As a Marker For Stressmentioning

confidence: 99%

“…DHEA affects several metabolic and immunological functions and is associated with lower incidence of ischemic heart disease and mortality from cardiovascular disease. (Izawa et al, 2008). Also DHEA is supposed to affect some brain functions such as cognition and mood (Izawa et al, 2008).…”

Section: Salivary Dhea As a Marker For Stressmentioning

confidence: 99%

“…(Izawa et al, 2008). Also DHEA is supposed to affect some brain functions such as cognition and mood (Izawa et al, 2008). For example, Izawa et al found that "acute psychosocial stress significantly increased salivary DHEA levels by an average of 60% and the response was moderately correlated to the cortisol response" (Izawa et al, 2008;Shirotsuki et al, 2009).…”

Section: Salivary Dhea As a Marker For Stressmentioning

confidence: 99%

See 2 more Smart Citations

Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

View full text Add to dashboard Cite

Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health

Marceau

Ruttle

Shirtcliff

et al. 2014

Developmental Psychobiology

100

View full text Add to dashboard Cite

Substantial research has implicated the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes independently in adolescent mental health problems, though this literature remains largely inconclusive. Given the cross-talk between the HPA and HPG axes and their increased activation in adolescence, a dual-axis approach that examines both axes simultaneously is proposed to predict the emergence and persistence of adolescent mental health problems. After briefly orienting readers to HPA and HPG axis functioning, we review the literature examining associations between hormone levels and changes with behavior during adolescence. Then, we provide a review of the literature supporting examination of both axes simultaneously and present the limited research that has taken a dual-axis approach. We propose future directions including consideration of between-person and within-person approaches to address questions of correlated changes in HPA and HPG hormones. Potential moderators are considered to increase understanding of the nuanced hormone–behavior associations during key developmental transitions.

show abstract

Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes

Cited by 98 publications

References 24 publications

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Salivary VIP concentrations are elevated in humans after acute stress

Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health

Contact Info

Product

Resources

About