Salivary Diagnostics Using Purified Nucleic Acids

Slowey, Paul D.

doi:10.1007/978-1-4939-6685-1_1

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…Consequently, we chose to examine both homologues in the current study. A number of studies show that saliva is a reasonable target tissue for gene expression studies 68 including behavioral disorders 69 . The use of peripheral biomarkers, and gene expression, in particular, to better understand the combined role of genes, their pathways and environment, is gaining traction 70 in clinical psychiatry 71 , neurology 72 , drug discovery 73 , cancer treatment 74 and psychology 53 .…”

Section: Discussionmentioning

confidence: 99%

Blending oxytocin and dopamine with everyday creativity

Chong

Tolomeo

Xiong

et al. 2021

Sci Rep

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Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA) pathways, yet the link between CT and CD38, CD157, dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of CT. To address this issue, two principal domains of CT, divergent thinking (AUT), were assessed. In men, both AUT is associated with gene expression of CD38, CD157, and their interaction CD38 × CD157. There were no significant associations for DA expression (DRD2, COMT, DRD2 × COMT) on both CT measures. However, analysis of the interactions of OT and DA systems reveal significant interactions for AUT in men. The full model explained a sizable 39% of the variance in females for the total CT score. The current findings suggest that OT and DA gene expression contributed significantly to cognition and CT phenotype. This provides the first empirical foundation of a more refined understanding of the molecular landscape of CT.

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Section: Discussionmentioning

confidence: 99%

Blending oxytocin and dopamine with everyday creativity

Chong

Tolomeo

Xiong

et al. 2021

Sci Rep

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“…One protocol recommended storing the supernatant from centrifuged saliva at cool temperatures but did not specify the temperature itself. 65 For cfDNA extraction from whole saliva, the recommended storage temperature is −80°C prior to DNA isolation. 65 The iSWAB-DNA Isolation Kit (Mawi DNA) allows for storage of samples for several months at ambient temperature.…”

Section: Introduction To Liquid Biopsymentioning

confidence: 99%

“… 65 For cfDNA extraction from whole saliva, the recommended storage temperature is −80°C prior to DNA isolation. 65 The iSWAB-DNA Isolation Kit (Mawi DNA) allows for storage of samples for several months at ambient temperature. 65 Stabilizing agents in other saliva collection tubes allow the samples to be stored at RT for up to a year.…”

Section: Introduction To Liquid Biopsymentioning

confidence: 99%

Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer

Batool,

Hsia,

Beecroft

et al. 2023

Cell Reports Medicine

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“…It has already been shown that saliva is a highly valid biological fluid that can be used for diagnostic applications [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Proteomics of the Salivary Fluid

Mitulović¹

2019

Salivary Glands - New Approaches in Diagnostics and Treatment

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Following the sequencing of the human genome, the mapping of the human proteome is the next task to being completed in order to gain knowledge on how proteins are involved in disease genesis, growth, therapy, and healing. As contrary to the genome, which is relatively static, the human proteome is significantly more complex and highly dynamic. Whilst the majority of the research is being focused on analyzing either the proteome of tumor tissues and tumor cells or the proteome of serum and plasma, little attention has been awarded to the analysis of proteomes in saliva or urine. The proteome in saliva can help providing important information on processes involving health issues in dentistry, head and neck cancers, gastric cancers or neurology, to name just a few. However, this is changing and the proteomics research community is increasingly focusing on deciphering the salivary proteome. So far, more than 3000 proteins have been identified in different studies and more is to come with new instrumentation and methods available. Some of the proteomics methods applied for analysis of salivary proteins will be discussed in this chapter.

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Salivary Diagnostics Using Purified Nucleic Acids

Cited by 6 publications

References 34 publications

Blending oxytocin and dopamine with everyday creativity

Blending oxytocin and dopamine with everyday creativity

Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer

Proteomics of the Salivary Fluid

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