Salivary duct carcinoma in the mandibular anterior region: The role of immunohistochemical markers in its definitive diagnosis

Chandrasekar, Chetana; Salati, Naser; Rao, Lakshmi; Radhakrishnan, Raghu

doi:10.4103/0973-029x.190955

Cited by 8 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Expression of immunomarkers varies according to the case and the variant, although positive results occur with the following: cytokeratins CK 5/6/7/14, epithelial membrane antigens (EMA), pankeratins, androgen receptors, S-100 protein from medial myoepithelial cells, and p40 and p63, p16, cancer proliferation marker Ki-67, CD 117, SOX-10, CAM5.2, GATA-3, and TTF-1 (Mlika et al, 2012;Schmitt et al, 2017;Udager et al, 2017). CK 7 is a marker indicative of glandular tissue which often used to differentiate salivary duct carcinoma from other metastatic disease since immuno-expression of CK 7 has positive immunoreactivity with most salivary gland malignancies (Chandrasekar et al, 2016). This patient's immunohistochemistry showed positive staining for pankeratin, CK 5 and 7, p16, SOX-10, p63, p40, increased Ki-67 expression, CAM-5.2 and CD-117.…”

Section: Discussionmentioning

confidence: 99%

Metastatic salivary duct carcinoma presenting as cannonball lung lesions on radiology: Case Report

Ignatowicz,

Strike,

Balaji

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland tumor with a high rate of metastasis and overall poor prognosis. SDC is commonly diagnosed at stage 3 or stage 4 with progression to local, regional lymph nodes or distant metastatic disease predominantly to the lung, bone, brain or skin. The case presents a 44 year old with an unusual presentation of distant metastasis appearing as cannon ball lesions in the lungs.Case presentation: The patient is a 44 year old male tobacco user with a history of recent incarceration who presented with a several month history of weight loss and enlarging right neck mass. He was found to have multiple bilateral lung masses with brain metastasis on imaging. Biopsy of the neck mass was consistent with salivary duct carcinoma with a rare basal-like phenotype. The patient was ultimately treated with targeted radiotherapy palliatively; however, he was not a candidate for chemotherapy due to extensive disease burden. He declined clinically and was transitioned to hospice care.Conclusions: The case provides a new presentation of an atypical salivary duct carcinoma with bilateral cannonball disease on imaging in addition to a rare histopathologic variant originating likely from an ex pleomorphic adenoma. The basal-like variant was found to have differing gene expression compared to the most commonly seen histological types. Considering the expression noted, the findings provide further information on the expression pattern of basal-like SDC for future targeted therapy and also clarify concerns with accurate diagnosis in SDC in comparison to other morphologically similar malignancies.

show abstract

Section: Discussionmentioning

confidence: 99%

Metastatic salivary duct carcinoma presenting as cannonball lung lesions on radiology: Case Report

Ignatowicz,

Strike,

Balaji

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Chandrasekar et al . (2016)[ 28 ] explored immunohistochemical markers for diagnosing salivary duct carcinoma and guiding diagnostics. Suvarna et al .…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the lower lip: A case report and review of literature

Bhargava,

Vats,

Singh

et al. 2023

Journal of Oral and Maxillofacial Pathology

View full text Add to dashboard Cite

Mucoepidermoid carcinoma (MEC) is a rare salivary gland malignancy characterized by diverse cellular components. This case report presents a unique instance of low-grade MEC in a 28-year-old female, emphasizing the importance of accurate diagnosis and tailored management. The patient exhibited a painless, enlarging lower lip swelling over a year, with imaging suggestive of a fibrolipomatous lesion. Surgical excision was successfully performed, with subsequent histopathological analysis displaying mucinous cystic spaces, varied epithelial cell types and other characteristic features consistent with MEC. The case findings aligned with hallmark MEC features are seen in established literature, highlighting the significance of precise diagnosis and grading for appropriate management. This report contributes to the understanding of MEC’s varied presentations and underscores the importance of thorough: histopathological examination, lower lip, mucoepidermoid carcinoma clinical evaluation, accurate histopathological analysis and interdisciplinary collaboration. The case highlights the value of considering MEC in younger patients, even with atypical presentations, and encourages ongoing exploration of diagnostic and therapeutic strategies to improve patient outcomes.

show abstract

“…The immunohistochemical characteristics of SDC cells include positive staining for human epidermal growth factor receptor (HER) 2, AR and CK7 ( 2 , 4 ). Since most salivary gland malignancies have positive immunoreactivity for CK7, immunoexpression of this protein may provide valuable information to differentiate primary salivary gland carcinomas from metastatic tumors ( 9 ). SDC usually shows negative results for expression of S-100, p63 and smooth muscle myosin ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Salivary Duct Carcinoma with Late Distant Brain and Cutaneous Metastasis: A Case Report

et al. 2020

View full text Add to dashboard Cite

Salivary duct carcinoma (SDC) is a rare and highly aggressive salivary gland tumor with poor prognosis, rapid growth, distant metastasis, early regional metastasis, and a high rate of recurrence. The parotid gland is the most common site of involvement, and the lungs and the bones are the most common sites of distant metastasis of SDC. Herein, we present a case of SDC of the parotid gland in a 62-year-old male patient with an unusual metastasis to the skin of the primary site and brain 6 years after primary treatment, which comprised of total parotidectomy and radical neck dissection followed by radiotherapy. It is noteworthy that in few cases of SDC with infiltration, (and not in low-grade intraductal carcinoma of the salivary glands), routine treatment may not suffice, and long-term follow-up is highly recommended.

show abstract

Salivary duct carcinoma in the mandibular anterior region: The role of immunohistochemical markers in its definitive diagnosis

Cited by 8 publications

References 32 publications

Metastatic salivary duct carcinoma presenting as cannonball lung lesions on radiology: Case Report

Metastatic salivary duct carcinoma presenting as cannonball lung lesions on radiology: Case Report

Mucoepidermoid carcinoma of the lower lip: A case report and review of literature

Salivary Duct Carcinoma with Late Distant Brain and Cutaneous Metastasis: A Case Report

Contact Info

Product

Resources

About