Salivary Fusobacterium Nucleatum Serves as a Potential Biomarker for the Diagnosis and Prognosis of Colorectal Cancer

Zhang, Xin; Zhang, Yaping; Gui, Xinru; Zhang, Zhenhong; Zhang, Xiaowei; Chen, Wendan; Wang, Yanxiang; Zhang, Mengjiao; Shang, Ziqi; Xin, Yiwei; Zhang, Yi

doi:10.2139/ssrn.3975353

Cited by 11 publications

(16 citation statements)

References 27 publications

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“…We further compare simulated and experimental KCl and NaCl solutions 68 to validate brine systems (Figure 4). Due to the lack of diffusion coefficients for brine systems in the literature, the values of density and viscosity are selected for the comparison.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The increasing trend of our simulations are in agreement with the experimental data regarding density (Figure 4a) and viscosity (Figure 4b) as the ion concentrations increase. 68 The magnitude of the deviations in viscosity (Figure 4b) could be affected by the complexity of the measurement in the experiment. Moreover, we have conducted a concise comparative analysis of the influence of the selected water model between TIP4P and SPC/E keeping all other simulation settings unaltered, as illustrated in Figure S2 of the Supporting Information, and we found that the water model has no significant effect on the results.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Figure 4. Variation of (a) the density and (b) viscosity of KCl and NaCl solutions versus the ion concentrations at 298 K and 1 atm 68. …”

mentioning

confidence: 99%

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Machine-Learning-Assisted Investigation of the Diffusion of Hydrogen in Brine by Performing Molecular Dynamics Simulation

Bhimineni,

Zhou,

Mahmoodpour

et al. 2023

Ind. Eng. Chem. Res.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Machine-Learning-Assisted Investigation of the Diffusion of Hydrogen in Brine by Performing Molecular Dynamics Simulation

Bhimineni,

Zhou,

Mahmoodpour

et al. 2023

Ind. Eng. Chem. Res.

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“…The mechanism of action of EOs depends on their chemical composition, and their biological activity cannot be attributed to a single mechanism but to a cascade of reactions involving the entire bacterial cell [9,14]. It has been proposed that components of EOs target the cell wall and cytoplasmic membrane through different mechanisms, including the modification of fatty acid composition, the loss of membrane potential, an increase in cell permeability, the alteration of ATPases and ATP production, the release of cytoplasmic contents, the inhibition of cell communication mechanisms, and alterations in amino acid biosynthesis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomics for Unraveling the Metabolic Changes in Planktonic and Sessile Cells of Salmonella Enteritidis ATCC 13076 after Treatment with Lippia origanoides Essential Oil

et al. 2023

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Nontyphoidal Salmonella species are one of the main bacterial causes of foodborne diseases, causing a public health problem. In addition, the ability to form biofilms, multiresistance to traditional drugs, and the absence of effective therapies against these microorganisms are some of the principal reasons for the increase in bacterial diseases. In this study, the anti-biofilm activity of twenty essential oils (EOs) on Salmonella enterica serovar Enteritidis ATCC 13076 was evaluated, as well as the metabolic changes caused by Lippia origanoides thymol chemotype EO (LOT-II) on planktonic and sessile cells. The anti-biofilm effect was evaluated by the crystal violet staining method, and cell viability was evaluated through the XTT method. The effect of EOs was observed by scanning electron microscopy (SEM) analysis. Untargeted metabolomics analyses were conducted to determine the effect of LOT-II EO on the cellular metabolome. LOT-II EO inhibited S. Enteritidis biofilm formation by more than 60%, without decreasing metabolic activity. Metabolic profile analysis identified changes in the modulation of metabolites in planktonic and sessile cells after LOT-II EO treatment. These changes showed alterations in different metabolic pathways, mainly in central carbon metabolism and nucleotide and amino acid metabolism. Finally, the possible mechanism of action of L. origanoides EO is proposed based on a metabolomics approach. Further studies are required to advance at the molecular level on the cellular targets affected by EOs, which are promising natural products for developing new therapeutic agents against Salmonella sp. strains.

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“…MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions, or products referred to in the content. obtained are not only tangible but also intangible, forests have an important role in producing products and driving ecosystems [3]. According to [4,5,6] protected forests need attention in management because they contribute to services and sources of biodiversity.…”

Section: Introductionmentioning

confidence: 99%

Anthropogenic Damage, Land Cover Change and Mitigation of Mount Hamiding Protected Forest Area in North Halmahera District, North Maluku Province-Wallace Zone, Indonesia

Kailola¹,

Purwanto²,

Sumardi³

et al. 2023

Preprint

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Mount Hamiding Protected Forest is located in North Halmahera Regency, North Maluku Province, the Wallace zone has an important role in providing protection functions, life support systems and regulating water management, preventing floods, preventing seawater intrusion, and controlling soil fertility. The protected forest area in the Wallace Zone is globally renowned for its endemic characteristics of flora and fauna. The condition of the protected forest of Mount Hamiding HMPF is currently experiencing anthropogenic damage as a result of forest encroachment, illegal logging, shifting cultivation, grazing and poaching to meet social needs. Anthropogenic damage has been in the spotlight for decades and has become a global issue. This study aims to determine damage to protected forests, changes in land cover, and mitigation of protected forest areas. This research uses quantitative and descriptive qualitative methods. Determination of research locations by purposive sampling. Parameters measured in this study were damage to protected forests, changes in land cover and area mitigation strategies. To identify forest damage, snowball sampling was carried out, and land cover changes through land cover data processing were obtained from the Ministry of Environment and Forestry of the Republic of Indonesia. Then using Imagery 7 ETM+ and 8 OLI to calculate changes in forested land to non-forested from 2006 -2021, analysis of land cover change using supervised classification, developing a strategy based on identity verification of forest damage and analysis of land cover change. The results showed that damage to protected forests was caused by anthropogenic disturbances in the form of forest encroachment, shifting cultivation, illegal logging, grazing and hunting of wild animals. Changes in land cover experienced the greatest damage in 2006-2021 amounting to 1,796.54 ha (16.17%). Strategic efforts are carried out using forest engineering, namely the agroforestry system and social engineering through community empowerment, namely training and outreach.

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Salivary Fusobacterium Nucleatum Serves as a Potential Biomarker for the Diagnosis and Prognosis of Colorectal Cancer

Cited by 11 publications

References 27 publications

Machine-Learning-Assisted Investigation of the Diffusion of Hydrogen in Brine by Performing Molecular Dynamics Simulation

Machine-Learning-Assisted Investigation of the Diffusion of Hydrogen in Brine by Performing Molecular Dynamics Simulation

Untargeted Metabolomics for Unraveling the Metabolic Changes in Planktonic and Sessile Cells of Salmonella Enteritidis ATCC 13076 after Treatment with Lippia origanoides Essential Oil

Anthropogenic Damage, Land Cover Change and Mitigation of Mount Hamiding Protected Forest Area in North Halmahera District, North Maluku Province-Wallace Zone, Indonesia

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