2022
DOI: 10.1016/j.isci.2022.104203
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Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

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Cited by 17 publications
(22 citation statements)
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“…Another recent study in CRC found that F. nucleatum DNA was increased in saliva of CRC patients compared to healthy controls. Receiver operating characteristic curves revealed that F. nucleatum DNA was superior in diagnosing CRC compared to carcinoembryonic antigen and carbohydrate antigen 19-9, the most frequently used noninvasive biomarkers for CRC diagnosis [54 ▪▪ ]. Similar results were observed in gastric cancer, where a recent study reported that salivary F. nucleatum could be used as a potential biomarker for gastric cancer diagnosis [55 ▪ ].…”
Section: Fusobacteria As a Biomarker For Cancer Diagnosis And Prognosismentioning
confidence: 59%
“…Another recent study in CRC found that F. nucleatum DNA was increased in saliva of CRC patients compared to healthy controls. Receiver operating characteristic curves revealed that F. nucleatum DNA was superior in diagnosing CRC compared to carcinoembryonic antigen and carbohydrate antigen 19-9, the most frequently used noninvasive biomarkers for CRC diagnosis [54 ▪▪ ]. Similar results were observed in gastric cancer, where a recent study reported that salivary F. nucleatum could be used as a potential biomarker for gastric cancer diagnosis [55 ▪ ].…”
Section: Fusobacteria As a Biomarker For Cancer Diagnosis And Prognosismentioning
confidence: 59%
“…Secondly, reliable and rapid measurement methods to validate the feasibility of Fn as a biomarker are lacking. Considering that Fn may originate from the oral cavity and that saliva is readily available through non-invasive routes, Zhang et al [ 86 ] reported that salivary Fn DNA could be used as a biomarker for colorectal cancer diagnosis and prognosis. In their research, they discovered that CRC patients with regional lymph node metastasis and distant metastasis had increasing levels of salivary Fn DNA (median: 4.662 IQR, 5.856 IQR, respectively).…”
Section: Discussionmentioning
confidence: 99%
“…The sensitivity and specificity levels for CRC in the test cohort were 86.7% and 67.2%, respectively, when the cutoff value was 0.437. Zhang et al [ 86 ] also identified a total of 1287 differentially expressed mRNAs based on different Fn DNA concentrations. Measuring the levels of salivary Fn DNA and related mRNAs appears to be more sensitive and suitable model than in vitro experiments and animal models.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to healthy controls, over-abundance of F . nucleatum was found in colorectal tissue biopsies [ 120 ] and saliva [ 121 ] in CRC patients. Identical strains of F. nucleatum were detected in their colorectal cancer and oral cavity, suggesting that F .…”
Section: Oral Microbiota Gut Microbiota and Systemic Diseasesmentioning
confidence: 99%