Salivary Gland Cancer in Patients Younger than 30 Years

Abstract

Previous research has shown that salivary gland tumors are rare in the young population. A clinical diagnosis has to be made very carefully because the proportion of malignancies is higher in children than in adults. We present a review of cases of malignant salivary gland carcinoma (SGC) in patients younger than 30 years of age. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 17 Registry. A total of 763 patients younger than 30 years with carcinoma of a major salivary gland from 1973 to 2004 were identifi ed within the SEER database. Th e most common salivary gland cancer was mucoepidermoid parotid gland carcinoma. Th e incidence of all major salivary gland carcinomas increased with increasing patient age. Th e 5-year relative survival rate for salivary gland carcinomas in our population was calculated according to the Kaplan-Meier analysis in each age group. Relative 5-year survival was 100% in the 1 patient younger than 1 year, 50.0% in the 1-to 4-year-old group; 87.2% among the 5-to 9-year-olds; 97.0% among the 10-to 14-year-olds; 95.0% among the 15-to 19-yearolds; 95.1% among the 20-to 24-year-olds; and 93.6% in the 25-to 29-year-old group. We found that SGC aff ects patients of all ages, even children in the fi rst year of life. It is essential for physicians to detect salivary gland neoplasms promptly and to evaluate them thoroughly when they are found in children. ASL Pharmacy® is also dispensing the AeroNeb® Go and the NeilMed® Sinus Rinse Bottle upon request. *ASL is not a Medicaid provider. NasoNeb is a trademark of MedInvent, LLC.

Pediatric parotid tumors: Clinical review of 24 cases in a Chinese population

“…In the present series, most pediatric epithelial parotid tumors (94.7%, 18 out of 19 cases) occurred in the second decade group with only one patient aged less than 10 years (6.3%, 1 out of 19 cases), which agrees with prior reviews [20][21][22]. It is extremely rare to diagnose a epithelial parotid tumor before age 10 years [23,24]; however, there is a dominance of nonepithelial tumors in the first years of life (100%, 5 out of 5 cases). Similar to other studies [21][22][23][24][25][26], we found that the most benign and malignant tumors of parotid gland in children were pleomorphic adenomas and mucoepidermoid carcinomas, and there was a female to male predominance.…”

“…It is extremely rare to diagnose a epithelial parotid tumor before age 10 years [23,24]; however, there is a dominance of nonepithelial tumors in the first years of life (100%, 5 out of 5 cases). Similar to other studies [21][22][23][24][25][26], we found that the most benign and malignant tumors of parotid gland in children were pleomorphic adenomas and mucoepidermoid carcinomas, and there was a female to male predominance. Almost all published epidemiological papers which analyzed the prevalence of salivary gland tumors in the head and neck region showed the singular predominance of pleomorphic adenoma (42.3-67.7%) among benign tumors [20,25,27,28], which is in agreement with our findings.…”

Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

“…Salivary gland cancer (SGC) in children accounts for only 5% of SGC in the general population, which in turn comprises 1% of all malignancies . SGC typically presents in children who are in the second decade of life, similar to children with benign salivary gland tumors . In children, salivary gland tumors are more often malignant than benign …”

“…1 SGC typically presents in children who are in the second decade of life, similar to children with benign salivary gland tumors. [1][2][3][4] In children, salivary gland tumors are more often malignant than benign. [3][4][5][6][7] Children with SGC most commonly present with a slowly enlarging mass in the major salivary glands or oral cavity over the past 8-12 months without metastases.…”

Radiation therapy for parotid gland tumors: long term data from a large single Institution experience.

“…The average age at diagnosis is about 60 years [3]; yet, these malignancies are not exceptional in younger ages. PGT are the most frequent salivary gland lesions, they are benign in about 70% of the cases and often arise from the super cial lobe of the gland [4,5]. PGT histological subtypes (HS) and cytological differentiation grade (DG) are extremely variable, as their clinical behavior.…”