“…These data demonstrate that feG does not require immunological or inflammatory pre-stimulation, such as that provided by the induction of acute pancreatitis in our previous model, to be effective. The tripeptide FEG (PheeGlueGly), derived from submandibular gland peptide T, and its synthetic counterpart, feG, inhibits cardiac, pulmonary and intestinal anaphylactic activity [5], and decreases pulmonary and pancreatic inflammation, with increased potency [4,26]. Previous mechanistic studies suggest that in vitro feG inhibits stimulated human and rat neutrophil expression of CD11b, and inhibits the expression of CD49d and CD16 antibody binding to peritoneal rat neutrophils [5].…”