Salivary gland epithelial neoplasms in pediatric population: a single-institute experience with a focus on the histologic spectrum and clinical outcome

Andreasen, Simon; Stevens, Elizabeth M.; Bjørndal, Kristine; Homøe, Preben

doi:10.1016/j.humpath.2017.11.021

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…A relatively high incidence of transient facial nerve paralysis was noted in the current study, a finding that conflicted with those of previous reports 1,2. The difference might be explained by the fact that total parotidectomy was the only surgical procedure performed, and any minor neurological dysfunction was defined as transient facial nerve paralysis in the current study.…”

Section: Discussioncontrasting

confidence: 99%

“…Parotid tumors are uncommon in children and adolescents, 10%–50% of which are malignant;1–3 the most common malignant lesion is MEC,4–12 and it is challenging to develop a consensus on treatment owing to the rarity of the disease. For cancers of the major salivary glands, surgical resection has been the primary treatment modality,12 but the optimal degree of surgery remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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<p>Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients</p>

Fang¹,

Liu²,

Seng³

2019

CMAR

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BackgroundThe goal of this study was to investigate the long-term oncologic outcome of parotid mucoepidermoid carcinoma (MEC) in pediatric patients.Patients and methodsPatients <19 years old who were diagnosed with MEC from January 1990 to December 2017 were retrospectively enrolled in this study. The main analyzed indexes included intraparotid node (IPN) metastasis, neutrophil-tolymphocyte ratio (NLR), loco-regional control (LRC), and disease-specific survival (DSS) rates.ResultsA total of 73 patients were enrolled. IPN metastasis occurred in 13 (17.8%) patients; the mean value of the NLR was 2.48 (range: 1.3–6.1). Loco-regional recurrence occurred in 12 patients, and 7 patients died of the disease. The 10-year LRC and DSS rates were 83% and 88%, respectively. IPN metastasis remained significantly related to recurrence in both univariate and Cox model analyses; a high NLR was significantly associated with recurrence in the univariate analysis but not in the Cox model. IPN metastasis remained significantly related to disease-related death in both the univariate and Cox model analyses; a high NLR was not associated with the DSS in univariate analysis.ConclusionThe long-term survival rate was relatively favorable in pediatric MEC. IPN metastasis was an independent risk factor for loco-regional recurrence and DSS. The role of the NLR in predicting survival in parotid cancer requires more research.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients</p>

Fang¹,

Liu²,

Seng³

2019

CMAR

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“…Acinic cell carcinoma/MEC and PA are the most frequent malignant and benign salivary gland tumors in children and adolescents, respectively (4). In contrast to previous studies, malignant tumors does not constitute a larger proportion of salivary gland tumors in children (4,5).…”

Section: Tumors Of the Salivary Gland Distribution And Clinical Charamentioning

confidence: 75%

An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

Andreasen

Kiss

Mikkelsen

et al. 2019

APMIS

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The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.

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Head and Neck Malignancies

Lampri

Papoudou‐Bai

2023

Intraoperative Flow Cytometry

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Salivary gland epithelial neoplasms in pediatric population: a single-institute experience with a focus on the histologic spectrum and clinical outcome

Cited by 3 publications

References 6 publications

<p>Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients</p>

<p>Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients</p>

An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

Head and Neck Malignancies

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