Salivary Gland Neoplasms in Children

Deng, Runzhi; Huang, Xiaofeng; Hao, Jian; Ding, Jie; Hu, Qingang

doi:10.1097/scs.0b013e3182801866

Cited by 22 publications

(19 citation statements)

References 10 publications

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“…It is suggested that in the pediatric population, like in adults, the parotid gland is the most common site involved by pleomorphic adenoma. When a tumor is situated in the submandibular gland it is also mostly a benign lesion, which is not in agreement with studies on adults [2,11,12].…”

Section: Discussioncontrasting

confidence: 67%

“…However, they mostly affect the parotid gland and are more common in those over ten years old, with approximately 70% occurring between 16 and 20 years of age [1]. Nevertheless the most common epithelial tumors of the major salivary glands in children and adolescents are pleomorphic adenomas (PA) [2]. However, few authors have reported the various pathological characteristics of major salivary gland tumors in children as well as adolescents and adults [3].…”

Section: Introductionmentioning

confidence: 99%

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Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Zieliński¹,

Kobos²,

Zakrzewska³

2016

pjp

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While Ki-67 expression is frequently used as an indicator of tumor cell proliferation, alternative markers have also been proposed. Possible alternative indicators of proliferation are the minichromosome maintenance (MCM) proteins, whose levels are inversely associated with tumor cell differentiation. The aim of this preliminary study was to compare the levels of Ki-67 and MCM-3 expression in major salivary gland epithelial tumors in all children and adolescents who underwent surgery in our department in the years 2009-2014. The histopathological diagnosis of the subjects was reviewed, as well as the expression of Ki-67 and MCM-3 in post-op specimens of the tumors. The normality of data was checked with the Shapiro-Wilk test. The t test for independent variables or the U test was used as appropriate to determine statistically significant differences in the expression of Ki-67 and MCM-3. Five cases of pleomorphic adenoma, one of myoepithelioma, one of basal cell adenoma and one of mucoepidermoid carcinoma were identified. Significantly greater MCM-3 than Ki-67 expression was observed in every case. The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Zieliński¹,

Kobos²,

Zakrzewska³

2016

pjp

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“…Mean and median age were 14.2 years (range: 1-19 years; 95% CI: 14.1-14.3 years), and female to male ratio was 1.4 (95% CI 1.3-1.4) ( Figure 1, Table 1). [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Ten studies (n = 329) reported on primary symptoms. Six of these (n = 227) reported that a solid tumor mass was present in 99% (n = 226) of children, five studies (n = 188) reported that 22% (n = 41) of children experienced pain from their tumors, and nine studies (n = 310) reported 7% (n = 22) facial nerve involvement.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…The third most common type was AdCC in the parotid glands (5%; n = 21), AciCC in the submandibular glands (9%; n = 4), and adenocarcinoma (not otherwise specified) in the minor salivary glands (9%; n = 9) ( Figure 2, Supporting Information Tables S2 and S3). 11,13,14,[16][17][18][19][20][21][22][24][25][26][27][28] Grade of differentiation was only available for MEC, in a total of 11 studies (n = 182). Overall, 87% of the SGCs were of low/intermediate grade (n = 158) and 10% were of high grade (n = 18) (Supporting Information Table S4).…”

Section: Tumor Characteristicsmentioning

confidence: 99%

Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

Garset‐Zamani

Grønhøj

Jensen

et al. 2018

Pediatric Blood & Cancer

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A systematic search of PubMed, EMBASE, and the Cochrane Library for studies from 2000 to 2017 including children aged 0‐19 with salivary gland cancer was performed. In 19 studies, 749 children (median age of 14.2 years, female to male ratio of 1.4:1) were included; 72% had parotid tumors and 95% underwent surgery, of whom 65% had surgery alone and 24% with adjuvant radiotherapy. Low‐grade and stage mucoepidermoid carcinoma were the most frequent cancer. The 5‐year overall‐ and disease‐free survival was 94% and 83%. Recurrence was observed in 20% at a median of 1.1 years from diagnosis.

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“…Salivary gland tumors are rare in children, with an estimated annual incidence of 0.8 per million [1,2]. About half of such tumors are malignant [2][3][4], and most are well to moderately differentiated without nodal involvement or distant metastasis [5,6]. The 5-year survival rates for pediatric patients with malignant salivary gland tumors range from 85% to 98% [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics.

Grant

Grosshans

Mahajan

2015

JCO

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Purpose-We evaluated acute toxicity profiles and dosimetric data for children with salivary gland tumors treated with adjuvant photon/electron-based radiation therapy (X/E RT) or proton therapy (PRT). Methods and Materials-We identified 24 patients who had received adjuvant radiotherapy for salivary gland tumors. Data was extracted from the medical records and the treatment planning systems. Toxicity was scored according to the Common Terminology Criteria for Adverse Effects 4.0. Results-Eleven patients received X/E RT and 13 PRT, with a median prescribed dose of 60 Gy in each group. In the X/E RT group, 54% of patients developed acute grade II/III dermatitis, 27% grade II/III dysphagia, and 91% grade II/III mucositis, and the median weight loss was 5.3% with one patient requiring feeding tube placement. In the PRT group, 53% had acute grade II/III dermatitis, 0% grade II/III dysphagia, and 46% grade II/III mucositis, with a median weight gain of 1.2%. Additionally, PRT was associated with lower mean doses to several normal surrounding midline and contralateral structures.

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Salivary Gland Neoplasms in Children

Abstract: Salivary gland neoplasms in Chinese pediatric patients are rare. There is a female predominance. Most of the tumors occur among patients not younger than 10 years. The most common benign tumor is pleomorphic adenomas, and the most common malignant tumor is mucoepidermoid carcinomas.

Cited by 22 publications

References 10 publications

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis

Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics.

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