Salivary Gland Pathology in Sjögren's Syndrome

Campos, Joana; Hillen, Maarten R; Barone, Francesca

doi:10.1016/j.rdc.2016.03.006

Cited by 33 publications

(29 citation statements)

References 78 publications

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“…It should be noted that representative of the everyday scenario in salivary gland clinics, the study population was composed of patients with different etiologies for dry mouth, and consequently, different underlying pathological mechanisms. For example, the largest group in this cohort was Sjögren's syndrome patients in whom the glands' impairment is caused by immune dysregulation processes mainly affecting the acinar compartment of the gland (Campos, Hillen, & Barone, ). Conversely, in the "radioactive iodine‐induced" group, the main affected part is the luminal ductal cells, which contain the sodium/iodide symporters that account for increased accumulation of I‐131 (Aframian et al, ; Van Nostrand, ).…”

Section: Discussionmentioning

confidence: 99%

Improvement of dry mouth following intraductal irrigation of salivary glands

et al. 2019

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Objectives To assess the effect of major salivary gland intraductal irrigations (IGs) to relieve mouth dryness. Methods We retrospectively analyzed the records of patients with mouth dryness who underwent major salivary gland IG during 2013–2015. Records included demographics, medical background, dry mouth etiologies and symptomatology, and results of sialometry and sialo‐cone‐beam computerized tomography. Subjective improvement following the IG procedure (yes/no) and sustained subjective improvement (mouth dryness relief for ≥1 month) were recorded. Objective improvement was assessed by comparing the mean unstimulated (USF) and stimulated (SSF) whole salivary flow (WSF) rate before and after the IG. Results Seventy‐four patients were included [mean age: 59.08 ± 12.46 years]. Improvement was detected in the USF (p = .027), but not in the SSF (p = .878). Fifty‐five (84.6%) noted subjective improvement, while 10 (15.4%) did not. Subjective improvement was positively associated with the USF following IG (p = .037), with salivary gland swelling episodes (p = .033), and with difficulties in swallowing dry foods (p = .014). Of those with subjective improvement, 45 (81.8%) reported sustained improvement, which was positively associated with lack of a gritty eye sensation (p = .042) and abnormal sialo‐CBCT findings (p = .001). Conclusions Major salivary gland IG is a simple and safe procedure that may relieve dry mouth for a relatively extended duration. Further studies are needed to confirm these preliminary findings and assess their underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Improvement of dry mouth following intraductal irrigation of salivary glands

et al. 2019

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“…The report may conclude that this is 'compatible with SS'. In fact, chronic sialadenitis can be found in normal individuals and this should be classed as a negative biopsy 1 4 7 11 16 . AECG criteria order to objectively assess xerophthalmia through simple, economic tests such as Rose Bengal staining and the Schirmer test, which can be used to strongly support or refute the suspicion of SS 22 .…”

Section: Sjögren's Syndrome (Ss)mentioning

confidence: 99%

“…In these conditions, the parenchyma of salivary glands, salivary ducts, or both represent the target of an attack carried out by the immune system against its own tissues, through autoantibodies and T cells. Sjögren's syndrome (SS) and immunoglobulin G4-related diseases (IgG4-RD) are the main chronic autoimmune sialadenitis 1 2 .…”

Section: Introductionmentioning

confidence: 99%

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Sialendoscopic management of autoimmune sialadenitis: a review of literature

Gallo

Martellucci

Fusconi

et al. 2017

Acta Otorhinolaryngol Ital

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Le patologie autoimmuni delle ghiandole salivari maggiori comprendono la sindrome di Sjögren e linsieme di condizioni morbose raccolte sotto il nome di patologie IgG4-correlate. Tanto la sindrome di Sjögren quanto le patologie IgG4-correlate sono caratterizzate da una reazione autoimmune mediata dai linfociti T-Helper il cui bersaglio è rappresentato dai dotti delle ghiandole esocrine nella sindrome di Sjögren e dal parenchima ghiandolare nelle malattie IgG4-correlate. Queste ultime, di introduzione relativamente recente, coinvolgono solitamente molti organi tra cui le ghiandole salivari. Negli ultimi anni patologie un tempo note come malattia di Mikulicz e tumore di Kuttner sono state classificate come le patologie IgG4-correlate limitate alle ghiandole salivari maggiori e denominate scialoadeniti IgG4-correlate. Questa breve revisione riassume la patogenesi e le principali caratteristiche cliniche delle ghiandole salivari maggiori sottolineando il potenziale ruolo diagnostico e terapeutico delle scialoendoscopia.

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“…In SS, target organs are quite limited. That is, exocrinopathy is the main feature of SS in that it involves lacrimal and salivary glands (Campos et al, 2016;Rischmueller et al, 2016). Dysfunction of these glands is termed sicca syndrome, meaning clinical manifestation of dryness (Rischmueller et al, 2016).…”

Section: Introductionmentioning

confidence: 99%