Salivary Gland Secretion

Proctor, Gordon; Shaalan, Abeer

doi:10.1016/b978-0-12-809954-4.00037-2

Cited by 4 publications

(8 citation statements)

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“…This cascade of events ultimately forms multiple secretory units, each consisting of a terminal acinar (serous/mucous) cell, myoepithelial cell, intercalated duct, striated duct, and excretory duct, as elaborated in Figure 1 [1,2]. [5,6] with permission. Ducto-acinar architecture of salivary glands is divided by capsular connective tissue septa into lobules.…”

Section: Introductionmentioning

confidence: 99%

“…Ultimately, the striated ducts drain into the excretory ducts (also known as interlobular ducts) with tall columnar epithelial cells. Figure adapted from Tran et al, 2019 and Proctor and Shaalan, 2018 [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…In this paper, we delve into the molecular pathways of salivary gland tumorigenesis, highlighting recent diagnostic protocols that may facilitate the identification and management of SGN. [5,6] with permission. Ductoacinar architecture of salivary glands is divided by capsular connective tissue septa into lobules.…”

Section: Introductionmentioning

confidence: 99%

“…Schematic representation of the histology of salivary glands. Reprinted from[5,6] with permission. Ducto-acinar architecture of salivary glands is divided by capsular connective tissue septa into lobules.…”

mentioning

confidence: 99%

“…(A) Histogenic concepts. (B) Morphogenic concepts.Reprinted from[2,5,6,13] with permission. Figure2Adepicts the four histogenic concepts that emphasize reserve cells of the salivary gland that replicate pathologically to form SGN (the cell type is highlighted in red for each theory): (i) Basal reserve cell theory-basal cells of excretory and intercalated ducts; (ii) pluripotent unicellular reserve cell theory-basal cells of the excretory duct; (iii) semi-pluripotent bicellular reserve cell theory-basal cells of the excretory duct and intercalated duct; (iv) multicellular theory-all mature acinar and basal cells.…”

mentioning

confidence: 99%

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An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Iyer

Hariharan

Cao

et al. 2021

Cancers

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Salivary gland neoplasms (SGN) remain a diagnostic dilemma due to their heterogenic complex behavior. Their diverse histomorphological appearance is attributed to the underlying cellular mechanisms and differentiation into various histopathological subtypes with overlapping features. Diagnostic tools such as fine needle aspiration biopsy, computerized tomography, magnetic resonance imaging, and positron emission tomography help evaluate the structure and assess the staging of SGN. Advances in molecular pathology have uncovered genetic patterns and oncogenes by immunohistochemistry, fluorescent in situ hybridization, and next–generation sequencing, that may potentially contribute to innovating diagnostic approaches in identifying various SGN. Surgical resection is the principal treatment for most SGN. Other modalities such as radiotherapy, chemotherapy, targeted therapy (agents like tyrosine kinase inhibitors, monoclonal antibodies, and proteasome inhibitors), and potential hormone therapy may be applied, depending on the clinical behaviors, histopathologic grading, tumor stage and location, and the extent of tissue invasion. This review delves into the molecular pathways of salivary gland tumorigenesis, highlighting recent diagnostic protocols that may facilitate the identification and management of SGN.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Iyer

Hariharan

Cao

et al. 2021

Cancers

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Oral Conditions as Risk Factors for Low Oral Health-Related Quality of Life Among the Elderly Population in Yogyakarta, Indonesia

et al. 2022

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Objective Approximately 70% of the elderly population living in Yogyakarta, Indonesia, has a low oral health-related quality of life (OHRQoL). This study aimed to identify the risk factors for low OHRQoL in the elderly population of Yogyakarta. Materials and Methods Oral Hygiene Index Simplified (OHI-S), Community Periodontal Index, Decayed, Missing, and Filled Teeth (DMFT) Index, and the number of natural occluding pairs (NOP) were assessed for 153 participants aged ≥ 60 years. Xerostomia, hyposalivation, and OHRQoL were also examined using Xerostomia Inventory (XI), unstimulated spitting whole saliva collecting method, and Geriatric Oral Health Assessment Index (GOHAI) questionnaire, respectively. OHRQoL was categorized as low, moderate, and high. Statistical Analysis Bivariate and multivariate tests were conducted to identify the risk factors for low OHRQoL. Results Initial analysis of characteristics of participants revealed that hyposalivation, xerostomia, periodontal pocket, high DMFT, NOP ≤ 5, poor OHI-S, and low OHRQoL were experienced by 40 (26.1%), 92 (60.1%), 39 (25.5%), 110 (71.9%), 112 (73.2%), 44 (28.8%), and 108 (70.6%) participants, respectively. Relative risk (RR) and p values for hyposalivation, xerostomia, periodontal pocket, high DMFT, NOP ≤5, and poor OHI-S were found to be at 1.573 (CI 0.681–3.637) and 0.225; 2.532 (CI 1.255–5.108) and 0.006; 0.846 (CI 0.391–1.830) and 0.606; 1.759 (CI 0.843–3.670) and 0.110; 1.133 (CI 0.522–2.461) and 0.008; and 2.723 (CI 1.293–5.734) and 0.632, respectively. Multivariate tests showed that xerostomia and NOP ≤5 had RR of 2.519 (CI 1.221–5.195) and 2.536 (CI 1.175–5.477), respectively. Conclusions Overall, elders with xerostomia or NOP ≤ 5 had 2.5 times higher risk of having a low OHRQoL.

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Salivary gland function, development, and regeneration

Chibly

Aure

Patel

et al. 2022

Physiological Reviews

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Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disease and injury will direct the development of therapy to repair and regenerate them. Significant recent advances, particularly in the OMICS field, increase our understanding of how salivary glands develop at the cellular, molecular and genetic levels; the signaling pathways involved, the dynamics of progenitor cell lineages in development, homeostasis and regeneration and the role of the extracellular matrix microenvironment. These provide a template for cell and gene therapies as well as bioengineering approaches to repair or regenerate salivary function.

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Salivary Gland Secretion

Cited by 4 publications

References 161 publications

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Oral Conditions as Risk Factors for Low Oral Health-Related Quality of Life Among the Elderly Population in Yogyakarta, Indonesia

Salivary gland function, development, and regeneration

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