Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib

Cipriani, Nicole A.; Blair, Elizabeth A.; Finkle, Joshua H.; Kraninger, Jennifer L.; Straus, Christopher M.; Villaflor, Victoria M.; Ginat, Daniel Thomas

doi:10.1177/1066896917709350

Cited by 51 publications

(36 citation statements)

References 23 publications

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“…Cipriani et al . recently published on CDKN2A/B loss in a case of salivary gland mammary secretory analogue carcinoma . Therein, the investigators demonstrated the loss of the tumour suppressor genes in a tumour with high‐grade transformation.…”

Section: Discussionmentioning

confidence: 99%

“…Cipriani et al recently published on CDKN2A/B loss in a case of salivary gland mammary secretory analogue carcinoma. 57 Therein, the investigators demonstrated the loss of the tumour suppressor genes in a tumour with high-grade transformation. In both cases, loss of these genes led to the dysregulation of the cell cycle and aggressive nature of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

et al. 2019

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Aims Secretory carcinoma of the breast (SCB) is a rare histological type of breast carcinoma with a generally indolent clinical behaviour. We aim to elucidate the clinical, pathological and molecular findings of SCB cases and identify characteristics associated with aggressive clinical courses. Methods and results Fourteen patients with SCB were identified, including 12 women and two men, with a median age of 56 years (range = 8–81 years). Clinical data, histological diagnosis, molecular findings and follow‐up were reviewed. Eight patients presented with palpable masses and four patients with radiographic abnormalities. All cases were unilateral. Surgical procedures included excisional biopsies and ipsilateral mastectomies. In 10 cases, oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) results were obtained, with six cases positive for ER and three positive for PR. All cases lacked HER2 overexpression. Sentinel lymph node biopsy was performed in 10 cases, and two patients had axillary lymph node metastasis. Follow‐up ranged from 21 to 212 months (median = 70 months). Two patients developed distant metastasis of SCB. Molecular analysis of these aggressive tumours revealed amplification of the 16p13.3 locus, a TERT promotor mutation and loss of 9p21.3 locus. Review of the literature for SCB cases with distant metastasis was performed. Conclusions Although SCBs are generally associated with a favourable prognosis, our study and review demonstrate that a subset of SCBs may develop distant metastases. Further studies are warranted to identify markers predictive of more aggressive clinical behaviour in this rare breast cancer subtype.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

et al. 2019

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“…High grade transformation is a rare phenomenon that has been described in an expanding list of salivary gland carcinomas [26], including SCs. To date (including the current case), HGT has been reported in seven patients of SCs [10,20,[27][28][29]. The sites of origin of these cases were parotid gland (n = 3), palate (n = 1), buccal space (n = 1), sinonasal tract (n = 1, the current case), and unspecified (n = 1).…”

Section: Discussionmentioning

confidence: 78%

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Aryeequaye

Wang

et al. 2017

Head and Neck Pathol

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Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients.

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“…In SC, the first case of HGT was reported by Jung et al, the authors noted the histological feature resemble to high-grade differentiated acinic carcinoma [17]. As far as I searched, only 16 cases HGT SC has been reported [7,8,11,[17][18][19][20][21]. Histologically, the high-grade transformation area is characterized by solid growth with atypical tumor cells and the high-grade transformation area with comedo necrosis adjacent to follicular structure site tend to demonstrate a more aggressive nature and ultimately a poor prognosis [6].…”

Section: Discussionmentioning

confidence: 99%

“…The high-grade transformation behaves more aggressively and is more associated with a poor prognosis than a low-grade tumor. SC with high-grade histology is rare and only 16 cases have been reported to this date [7,8,11,[17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Takabatake

Nakano

Kawai

et al. 2020

Reports

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Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

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Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib

Cited by 51 publications

References 23 publications

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

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