Salivary gland tumors: A 20-year review of clinical diagnostic accuracy at a single center

Lee, Wei‐Han; Tseng, Te Ming; Hsu, Hsin-Te; Lee, Fei Peng; Hung, Shih‐Han; Chen, Po‐Yueh

doi:10.3892/ol.2013.1750

Cited by 25 publications

(20 citation statements)

References 31 publications

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“…Four out of six cases that presented with pain in our study were diagnosed as malignant by histopathology and similar presentations had been reported by others. 17 A good clinical concordance observed in our study supports a strong clinical history. Other studies had also reported clinical accuracy of 100% and 57% for diagnosing benign and malignant cases respectively 17 though others had reported that no single feature or group of features led to clinical diagnosis of a specific tumor type.…”

Section: Discussionsupporting

confidence: 86%

Evaluation of salivary gland tumors- clinically radiologically and pathologically: prospective study

Sharma

2021

Int J Otorhinolaryngol Head Neck Surg

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Background: Salivary gland tumors are difficult to differentiate based solely on clinical presentation or cytological findings due to their overlapping pictures. Often inadequate samples from cytology pose a challenge in preoperative diagnosis. Histopathology is considered the gold standard in diagnosing these tumors. The purpose of this study was to determine clinical, radiological, and cytological findings of these tumors and to assess the accuracy of these results with that of histopathological diagnosis.Methods: Prospectively 52 patients with salivary gland swellings were enrolled between 2007-2009. Cases with inflammatory swelling were excluded from the study. Demographic, clinical history, preoperatively ultrasonography, cytology, and histopathological data were collected and analyzed.Results: Most cases (65.38%) had parotid gland involvement. Benign tumors were common (80.76%) with pleomorphic adenoma as the most common one. Malignant tumors comprised 19.23%. Mucoepidermoid carcinoma and adenoid cystic carcinoma were common malignant tumors. Local swelling was the most common clinical presentation, and no facial nerve involvement was reported. The hard palate was the most common minor salivary gland affected predominantly by benign tumors. The diagnostic accuracy of fine-needle aspiration cytology was 96.15%, followed by clinical and radiological diagnostic accuracy of 92.31% and 86.54%, respectively. Using McNemar's test, a significant agreement was found between clinical and histological diagnosis (p=0.1336) and between FNAC and histological diagnosis (p=0.4975).Conclusions: Fine needle aspiration cytology is a highly accurate, sensitive, and specific screening technique. It is safe and reliable, though minimally invasive. Ultrasonography-guided cytology along with clinical, and radiological findings could enhance the pre-operative diagnostic accuracy in distinguishing salivary gland tumors.

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Section: Discussionsupporting

confidence: 86%

Evaluation of salivary gland tumors- clinically radiologically and pathologically: prospective study

Sharma

2021

Int J Otorhinolaryngol Head Neck Surg

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“…However, the sensitivity and accuracy of FNAC in the detection of malignant characteristics in Ca ex PA are 60% and 46%, respectively[10]. Another retrospective study confirmed that clinical judgment of benign and malignant tumors in the submandibular gland had a low accuracy of 67%[11], so intraoperative frozen section analysis results were particularly important in determining the extent of surgical resection. Unfortunately, there was no accurate diagnosis made before surgery on our patient, so it can only be diagnosed by the intraoperative frozen section analysis.…”

Section: Discussionmentioning

confidence: 99%

Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report

Chen

Tu²,

Zhao

et al. 2019

WJCC

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BACKGROUND Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial. CASE SUMMARY This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. She accepted surgery to remove the mass; she was found to have lung metastasis after radiotherapy. Her condition was controlled by chemotherapy with liposomal doxorubicin plus cisplatin. CONCLUSION The positive clinical outcome in the patient reveals that this chemotherapy regimen may be an alternative treatment for such a condition.

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“…Moreover, cleavage of Bid has been established as a linker of both apoptotic pathways, therefore compounds able to induce Bid cleavage and activate caspase 8 on one side as well as cytochrome c release and caspase 9 on the other side, represent synergistic mediators of extrinsic and intrinsic apoptotic event. Here we should mention celastrol (55) [239], sulphoraphane (85) [240] or quercetin (12) [241].…”

Section: Rhus Vernicifluamentioning

confidence: 99%

Power from the Garden: Plant Compounds as Inhibitors of the Hallmarks of Cancer

Orlikova

Diederich

2012

CMC

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On December 23rd, 1971, President Richard Nixon signed the National Cancer Act and invested more than $ 100 million "to launch an intensive campaign to find a cure for cancer". Today, despite these considerable efforts, cancer still remains a very aggressive silent killer all over the world. Moreover, over the last decade, novel synthetic chemotherapeutic agents currently in use in the clinics did not succeed in fulfilling their expectations even though they are very cost-intensive. In parallel, there is increasing evidence for the potential of plant-derived compounds on the inhibition of different steps of tumor genesis and associated inflammatory processes, underlining the importance of these products in cancer prevention and therapy. This review summarizes the impact of selected natural compounds on the eight major alterations, known as the cancer hallmarks, and also on their two enabling characteristics that were coined by Hanahan and Weinberg earlier. Altogether these ten alterations are responsible for the progressive transition of healthy cells into neoplastic ones and their further dissemination in the body. With this review, we try to highlight molecular mechanisms by which plant extracts and their purified active components fight and overcome these pathological variations of the cell signaling pathways for the improvement of prevention and therapy. We truly believe that all diseases can be found in Nature and that Nature also provides the efficient cures.

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Salivary gland tumors: A 20-year review of clinical diagnostic accuracy at a single center

Cited by 25 publications

References 31 publications

Evaluation of salivary gland tumors- clinically radiologically and pathologically: prospective study

Evaluation of salivary gland tumors- clinically radiologically and pathologically: prospective study

Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report

Power from the Garden: Plant Compounds as Inhibitors of the Hallmarks of Cancer

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