Salivary Gland Tumors after Childhood Radiation Treatment for Benign Conditions of the Head and Neck: Dose-Response Relationships

Schneider, Arthur B.; Lubin, Jay H.; Ron, Elaine; Abrahams, Cyril; Stovall, Marilyn; Goel, Ankush; Shore-Freedman, Eileen; Gierlowski, Theresa C.

doi:10.2307/3579909

Cited by 71 publications

(50 citation statements)

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“…Pleomorphic adenoma was the most common benign tumour, with slight female dominance occurring mainly in the third decade of life. 19,20 It most commonly affects the parotid gland, cytology of the tumour shows a bland epithelial cell in aggregates and sheets and fragments of the chondromyxoid fibrillary stroma. 19,20,22 This tumor posed no cytological difficulties in our study.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 It most commonly affects the parotid gland, cytology of the tumour shows a bland epithelial cell in aggregates and sheets and fragments of the chondromyxoid fibrillary stroma. 19,20,22 This tumor posed no cytological difficulties in our study. In present study Warthin's tumour, the second most common 1.6% benign tumour occurs mainly in the fourth to sixth decade, with a male preponderance.…”

Section: Discussionmentioning

confidence: 99%

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Cytopathological study of salivary gland lesion in patients at a tertiary care centre, Indore: a one-year study

et al. 2017

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Background: Fine needle aspiration cytology (FNAC) is being increasingly used in the diagnosis of salivary gland lesions. However, the diagnosis is still difficult sometimes. Salivary gland lesions account for 2-6.5% of all the neoplasms of the head and neck. The objective of this study was to evaluate the diagnostic accuracy and the sensitivity and specificity of FNAC in various salivary gland lesions and their histological correlation wherever possible.Methods: A total of 123 FNACs were done on salivary gland swellings in the Department of Pathology, M.G.M. Medical College, Indore, Madhya Pradesh, India. The PAP stained cytological and H and E stained histopathological slides were studied and correlated.Results: On FNAC, slides were studied and analyzed and the following lesions were observed: Inflammatory lesion (69), Inflammatory cystic lesion (1), Pleomorphic adenoma (29), monomorphic adenoma (1), Warthin’s tumour (2), Benign Cystic lesion (4), Benign lesion (not specified) (4), Adenoid cystic carcinoma (3), Mucoepidermoid carcinoma (2), Metastatic carcinoma (3), and malignant tumour (unspecified) (5). Histopathological correlation was available in 41 cases and studied respectively.Conclusions: The overall sensitivity, specificity and the diagnostic accuracy were 90.2%, 97.6%, and 90.2%, respectively. Hence, the appropriate therapeutic management could be planned earlier. This study documents that FNAC of the salivary gland tumours is accurate, simple, rapid, inexpensive, well tolerated and harmless procedure for the patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cytopathological study of salivary gland lesion in patients at a tertiary care centre, Indore: a one-year study

et al. 2017

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“…Previous studies have documented excesses of cancers of the breast, thyroid gland, CNS, salivary gland, bone and stomach associated with radiotherapy during childhood. 2,16,17,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The frequent use of extended field radiotherapy and combined modality treatments almost certainly contributed to the large EARs that were seen following Ewing sarcoma, HL and PNET. Patients diagnosed with HL or Ewing sarcoma also tended to be older and more likely to have attained ages at which background cancer incidence is greater.…”

Section: Discussionmentioning

confidence: 99%

New malignancies following childhood cancer in the United States, 1973–2002

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2007

Intl Journal of Cancer

180

183

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The objectives of our study were to quantify risks for developing new malignancies among childhood cancer survivors, identify links between particular types of first and subsequent cancer, and evaluate the possible role of treatment. A cohort of 25,965 2-month survivors of childhood cancer diagnosed in the U.S. during 1973-2002 was identified and followed through SEER cancer registries. Observed-to-expected ratios (O/E) were calculated, and Poisson regression was used to compare risks among treatment groups. Childhood cancer survivors were at nearly 6-fold risk of developing a new cancer relative to the general population (O/E 5 5.9, 95% CI: 5.4-6.5). Most common were subsequent primary cancers of the female breast, central nervous system, bone, thyroid gland and soft tissue, as well as cutaneous melanoma and acute non-lymphocytic leukemia (ANLL). The greatest risks of subsequent cancers occurred among patients diagnosed previously with Hodgkin lymphoma (HL), Ewing sarcoma, primitive neuroectodermal tumor, or retinoblastoma. Risk of subsequent solid cancers was higher among persons whose initial treatment for childhood cancer included radiotherapy, whereas the excess of subsequent ANLL was strongly related to chemotherapy. The O/E for subsequent ANLL increased with increasing calendar year of initial cancer diagnosis among survivors of cancers other than HL, most likely due to increasing use of leukemogenic drugs for solid cancers and nonHodgkin lymphoma. Childhood cancer survivors are at markedly increased risk of developing a variety of new cancers relative to the general population, but the magnitude of excess risk and specific types of second cancer vary widely by type of first cancer. ' 2007 Wiley-Liss, Inc.Key words: second cancers; multiple primary cancers; childhood cancer; epidemiology; surveillance, epidemiology and end results (SEER) registriesThe dramatic advances that have been made in the treatment of childhood cancer over the past several decades have created a large and growing population of long-term survivors.1 Although many childhood cancers now can be cured, the aggressive therapies used are associated with increased risks of a variety of adverse health effects, including new primary cancers.2-7 Opportunities for addressing second cancer risks in large populations of childhood cancer survivors followed over many years are uncommon. Rarely can individual medical centers achieve adequate sample sizes or follow-up, necessitating costly multicenter studies or the use of large, population-based cancer registries. Populationbased studies have advantages over most clinic-based studies in that study populations are unaffected by referral patterns, and completeness of follow-up is less likely to be related to the occurrence of a new cancer. We used data from the National Cancer Institute's Surveillance, Epidemiology and End-Results (SEER) population-based cancer registry in the U.S. to assess the risk of new primary cancers among persons diagnosed with childhood cancer between 1973 and 2002. Material ...

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“…Xerostomia is believed to be due to the delivery of Radiation therapy to the parotid glands, such adverse events can hopefully be avoided by delivering the radiationtherapy to the submandibular glands instead of the parotid glands (1). Due to long-term hazards of growth retardation and risk of malignancy radiation therapy has been criticized and abandoned from use for the pediatric population (21).…”

Section: Radiation Therapymentioning

confidence: 99%