Salivary gland tumors of the mandible

Martı́nez-Madrigal, Fernando; Pineda‐Daboin, Keyla; Casiraghi, Odele; Luna, Mario A.

doi:10.1053/adpa.2000.19395

Cited by 63 publications

(40 citation statements)

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“…Central (i.e., primary intraosseous) mucoepidermoid carcinoma (MEC) is a rare malignant neoplasm of the jaws that is identical in most respects to MEC of the salivary glands, but arises entirely within bone [1][2][3][4][5]. Glandular odontogenic cyst (GOC) is an uncommon benign cystic lesion of the gnathic bones initially described in 1987 as ''sialo-odontogenic cyst'' or ''mucoepidermoid odontogenic cyst.''…”

Section: Introductionmentioning

confidence: 99%

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Bishop

Yonescu

Batista

et al. 2014

Head and Neck Pathol

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Glandular odontogenic cyst (GOC) is a cyst of the gnathic bones that is characterized by squamous and glandular differentiation. The histopathologic features of GOC overlap considerably with central mucoepidermoid carcinoma (MEC), suggesting that GOC could be a precursor lesion to, or even a low-grade form of, central MEC. Differentiating the two lesions may be difficult or impossible on a limited biopsy. MAML2 rearrangements have been recently found to be specific for MEC, even those arising in the jaws. An analysis of MAML2 in GOCs could help clarify its relationship with central MEC. Tissue blocks from 21 GOCs and 5 central MECs were retrieved from the surgical pathology archives of The Johns Hopkins Hospital. Each MEC exhibited solid areas and clear-cut stromal invasion. In addition, 4 of the MECs demonstrated cystic areas that were histologically similar to GOC. Breakapart fluorescence in situ hybridization for MAML2 was performed. For the MECs, analysis was performed on both the solid components and the cystic areas that resembled GOC. MAML2 rearrangements were identified in all 5 of the MECs, but in none of the 21 GOCs (100 vs. 0 %; p \ 0.0001, Fisher's Exact). In the MECs, the rearrangement was present in both the solid and GOC-like cystic areas. While central MECs consistently harbor the MAML2 rearrangement, even in low-grade cystic areas that resemble a pre-existing GOC, true GOCs do not. Accordingly, GOC does not appear to represent an early or low-grade form of central MEC, but rather an unrelated lesion. The high sensitivity and specificity of MAML2 rearrangement for MECs points to its utility as a diagnostic adjunct in separating mucinous cystic lesions of the gnathic bones.

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Section: Introductionmentioning

confidence: 99%

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Bishop

Yonescu

Batista

et al. 2014

Head and Neck Pathol

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“…The institution of a quick treatment and a long period of monitoring, of around 10 years, is recommended in these cases, as no treatment method completely eliminated the possibility of an intraosseous ACC relapse (5). Even where adequate treatment is performed, recurrence is not infrequent, being as much as 42% 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Intraosseous occurrences of malignant salivary gland tumors are rare, with mucoepidermoid carcinoma being the most common, followed by ACC, which could complicate or even delay correct diagnosis. Various theories have been proposed to explain the origin of these neoplasms, including: a) tissue remains of ectopic salivary glands, b) neoplastic transformation of odontogenic epithelial cysts, and c) the neoplastic transformation of the sinus epithelium 5 .…”

Section: Introductionmentioning

confidence: 99%

Oral and maxillofacial rehabilitation of a patient suffering from intraosseous adenoid cystic carcinoma

Waechter

Xavier

Corrêa

et al. 2017

RGO, Rev. Gaúch. Odontol.

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RESUMOO tratamento das neoplasias em região de cabeça e pescoço pode deixar sequelas que afetam a qualidade de vida do paciente durante e após o tratamento. A comunicação buconasosinusal decorrente da ressecção cirúrgica parcial ou total do palato traz ao paciente alterações na função mastigatória, estética, fonética e de deglutição o que pode levar a um isolamento social do indivíduo. Em vista disso, a atuação do cirurgião dentista junto à equipe multiprofissional de atendimento ao paciente oncológico se faz fundamental, podendo contribuir no diagnóstico, auxiliar no manejo de complicações do tratamento quimioterápico/radioterápico, e na reabilitação bucomaxilofacial, sendo esta uma alternativa para melhorar a qualidade de vida do paciente, pois visa restabelecer as funções alteradas em decorrência do procedimento cirúrgico. O presente estudo relata o caso de uma paciente portadora de carcinoma adenóide cístico na maxila submetida à maxilectomia parcial, deixando como seqüela a comunicação buconasosinusal. O acompanhamento odontológico foi realizado no Hospital Escola da Universidade Federal de Pelotas no pré-operatório, durante e após o tratamento. No momento a paciente está reabilitada com uma prótese obturadora em acompanhamento pela equipe de odontologia e pelo cirurgião de cabeça e pescoço.Termos de indexação: Carcinoma adenoide cístico. Prótese maxilofacial. Neoplasias de cabeça e pescoço.

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“…They are known to occur primarily in the mandible and very few arise in the maxilla. Mucoepidermoid carcinoma is the most common intraosseous (central) malignancy of salivary gland differentiation accounting for 2%-4% of all mucoepidermoid carcinomas [1,2] . There are no reports of the occurrence of the sebaceous adenocarcinoma in the maxilla.…”

Section: Discussionmentioning

confidence: 99%

“…They present with swelling, pain and paresthesia. The mucoepidermoid carcinoma, adenoid cystic adenocarcinoma, adenocarcinoma NOS, acinic cell adenocarcinoma and the epithelial-myoepithelial carcinoma have all been reported within the jaws [1,2] . We document an interesting case of sebaceous adenocarcinoma arising in the maxilla.…”

Section: Introductionmentioning

confidence: 99%

Intraosseous sebaceous adenocarcinoma of the maxilla

Hoskoppal

Qayyum

Anderson

et al. 2015

CRCP

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Primary intraosseous salivary malignancies are rare. The adenoid cystic adenocarcinoma, adenocarcinoma not otherwise specified, acinic cell adenocarcinoma and the epithelial-myoepithelial carcinoma have all been reported within the jaws. The mucoepidermoid carcinoma is by far the most common tumor in this setting accounting for 2%-4% of all mucoepidermoid carcinomas. An intraosseous sebaceous adenocarcinoma has never been reported. We document a case of sebaceous adenocarcinoma of the maxilla in a 56-year-old woman who presented with a painful swelling of the right face. CT scans showed an expansile, osteolytic tumor of the right maxilla. An exploratory biopsy revealed the tumor to be expanding and eroding the cortical plates including the floor of the sinus. The histopathology was consistent with a sebaceous adenocarcinoma. The sebocytes expressed EMA and CD15. The basaloid cells were CD15 negative. The tumor was treated with a wide local resection. Post-surgical healing was uneventful and patient is being monitored regularly for recurrences. Prognosis of any tumor originating intraosseously is worse than its soft tissue counterpart. Extraocular sebaceous adenocarcinomas are low grade malignancies which can recur locally. As this is the first report of an intraosseous/central sebaceous adenocarcinoma, prognostication could be inaccurate and therefore long-term follow-up is highly recommended.

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Salivary gland tumors of the mandible

Cited by 63 publications

References 0 publications

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Oral and maxillofacial rehabilitation of a patient suffering from intraosseous adenoid cystic carcinoma

Intraosseous sebaceous adenocarcinoma of the maxilla

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