SALIVARY GLANDS; CLINICAL &amp; HISTOPATHOLOGICAL SPECTRUM OF ADENOID CYSTIC CARCINOMA  &amp; MUCOEPIDERMOID CARCINOMAS REPORTED AT TERTIARY CARE HOSPITALS  IN LAHORE

Hussain, Sunila; Naseem, Nadia; Siraj, Muhammad Rashid; Rehman, Fakeha; Qureshi, htesham-u-Din; Rasool, Ghulam; Nagi, A. H.

doi:10.17957/tpmj/17.3923

Cited by 2 publications

(6 citation statements)

References 15 publications

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“…16 The current study, showed slight female predominance with ratio of M:F=1:1.4.Another local study reported similar gender distribution in these tumors. 2 Females are reported to be more prone to be affected by MEC as compared to males with a ratio of 10:01 (17). On multivariate analysis, present study did not show any significant association between gender and grade of tumor.…”

Section: Discussioncontrasting

confidence: 67%

“…The studies conducted both nationally and internationally, also documented the similar findings as the parotid gland the most commonly involving site. 18 The highest involvement of parotid as compared to other glands is attributed to varying cell types that are present as compared to other salivary glands. Other reasons can be gland size and its proximity to the lymphatics and nerves.…”

Section: Discussionmentioning

confidence: 99%

“…1 In Pakistan, it is 50% of all malignant salivary gland tumors (SGTs) with an incidence rate of 2.87%. 2 It mainly occurs in 2nd to 4th decade of life as painless, slow growing mass that is fixed or firm lesion attaining size less than 4 cm with smooth to rounded, irregular, elevated, non-ulcerated margins. 3 The exact etiology is still unknown but MEC may occur due to genetic mutation or chromosomal translocation.…”

Section: Introductionmentioning

confidence: 99%

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2024

J Pak Dent Assoc

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OBJECTIVE:This study was conducted to determine PD-L2 expression and its association with grading in patients with mucoepidermoid carcinoma. METHODOLOGY: This descriptive study was conducted over a period of 1 year after taking approval from Institutional Ethical Review board. A total of twenty-four cases of MEC were recruited from different tertiary health care hospitals in Lahore and Multan. Data consisting of demographics and clinical features was collected. Histopathological analysis was done according to Seethala's grading system. Immunohistochemistry (IHC) was performed to observe PD-L2 expression. Data was analyzed by using SPSS 25. RESULTS: The mean age was 30.08±12.8 years and there were 41.7% males and 58.3% females. Most common site of involvement was found to be parotid gland. A total of (54.2%) cases were of low grade. Strong PD-L2 expression was observed in 12(50%) cases while in 5(21%) cases there was week expression. No significant association of PD-L2 expression with grade of tumor was observed. CONCLUSION: Among salivary gland tumors, Mucoepidermoid carcinoma is emerging as most frequently diagnosed malignancy. These tumors originate mainly from parotid glands usually during fourth decade of life. As preliminary data generated from current research has highlighted the expression of PD-L2 in malignant MEC. The expression of PD-L2 was observed in all of the tissue specimens in the current study as detected through IHC irrespective of the grade of the tumor.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2024

J Pak Dent Assoc

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Correlation Between Demographic Features and PD-L2 Expression in Mucoepidermoid Carcinoma of Salivary Glands

Zafar,

Anjum,

Chaudhry

2024

J Pak Dent Assoc

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OBJECTIVE: This study was conducted to determine PD-L2 expression and its association with grading in patients with mucoepidermoid carcinoma METHODOLOGY: : This descriptive study was conducted over a period of 1 year after taking approval from Institutional Ethical Review board. A total of twenty-four cases of MEC were recruited from different tertiary health care hospitals in Lahore and Multan. Data consisting of demographics and clinical features was collected. Histopathological analysis was done according to Seethala's grading system. Immunohistochemistry (IHC) was performed to observe PD-L2 expression. Data was analyzed by using SPSS 25 RESULTS: : The mean age was 30.08±12.8 years and there were 41.7% males and 58.3% females. Most common site of involvement was found to be parotid gland. A total of (54.2%) cases were of low grade. Strong PD-L2 expression was observed in 12(50%) cases while in 5(21%) cases there was week expression. No significant association of PD-L2 expression with grade of tumor was observed. CONCLUSIONS: Among salivary gland tumors, Mucoepidermoid carcinoma is emerging as most frequently diagnosed malignancy. These tumors originate mainly from parotid glands usually during fourth decade of life. As preliminary data generated from current research has highlighted the expression of PD-L2 in malignant MEC. The expression of PD-L2 was observed in all of the tissue specimens in the current study as detected through IHC irrespective of the grade of the tumor KEYWORDS: Programmed cell Death 1 Ligand 2 (PD-L2), Mucoepidermoid Carcinoma (MEC), ImmunohistoChemistry (IHC).

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SALIVARY GLANDS; CLINICAL & HISTOPATHOLOGICAL SPECTRUM OF ADENOID CYSTIC CARCINOMA & MUCOEPIDERMOID CARCINOMAS REPORTED AT TERTIARY CARE HOSPITALS IN LAHORE

Cited by 2 publications

References 15 publications

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Correlation Between Demographic Features and PD-L2 Expression in Mucoepidermoid Carcinoma of Salivary Glands

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