Salivary Glucose level as Noninvasive Diagnostic Tool for Monitoring Glycemic Control of Type 1 Diabetic Children

Shahin, Ashraf; Ati, R.I. Abdel; Fayd, S.M.; Mokhtar, Maha M.

doi:10.21608/bjas.2021.169126

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…DM patients’ blood glucose and parotid salivary glucose levels were substantially higher than those of the control group, and the parotid salivary glucose level was strongly associated with the DM patients’ blood glucose level. This is consistent with previous research [ 44 , 45 ]. Our study showed a significantly strong correlation between UPS and blood glucose levels, whereas there was a significant correlation between whole saliva and blood glucose levels.…”

Section: Discussionsupporting

confidence: 94%

Correlations of Salivary and Blood Glucose Levels among Six Saliva Collection Methods

Cui

Zhang

Zhu

et al. 2022

IJERPH

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Background: Saliva has been studied as a better indicator of disorders and diseases than blood. Specifically, the salivary glucose level is considered to be an indicator of diabetes mellitus (DM). However, saliva collection methods can affect the salivary glucose level, thereby affecting the correlation between salivary glucose and blood glucose. Therefore, this study aims to identify an ideal saliva collection method and to use this method to determine the population and individual correlations between salivary glucose and blood glucose levels in DM patients and healthy controls. Finally, an analysis of the stability of the individual correlations is conducted. Methods: This study included 40 age-matched DM patients and 40 healthy controls. In the fasting state, saliva was collected using six saliva collection methods, venous blood was collected simultaneously from each study participant, and both samples were analyzed at the same time using glucose oxidase peroxidase. A total of 20 DM patients and 20 healthy controls were arbitrarily selected from the above participants for one week of daily testing. The correlations between salivary glucose and blood glucose before and after breakfast were analyzed. Finally, 10 DM patients and 10 healthy controls were arbitrarily selected for one month of daily testing to analyze the stability of individual correlations. Results: Salivary glucose levels were higher in DM patients than healthy controls for the six saliva collection methods. Compared with unstimulated saliva, stimulated saliva had decreased glucose level and increased salivary flow. In addition, unstimulated parotid salivary glucose was most correlated with blood glucose level (R2 = 0.9153), and the ROC curve area was 0.9316, which could accurately distinguish DM patients. Finally, it was found that the correlations between salivary glucose and blood glucose in different DM patients were quite different. The average correlation before breakfast was 0.83, and the average correlation after breakfast was 0.77. The coefficient of variation of the correlation coefficient before breakfast within 1 month was less than 5%. Conclusion: Unstimulated parotid salivary glucose level is the highest and is most correlated with blood glucose level, which can be accurately used to distinguish DM patients. Meanwhile, the correlation between salivary glucose and blood glucose was found to be relatively high and stable before breakfast. In general, the unstimulated parotid salivary glucose before breakfast presents an ideal saliva collecting method with which to replace blood-glucose use to detect DM, which provides a reference for the prediction of DM.

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Section: Discussionsupporting

confidence: 94%