Salivary HPV infection in healthy people

Radwan-Oczko, Małgorzata; Owczarek-Drabińska, Joanna Elżbieta; Szczygielska, Anna; Szczepaniak, Marta; Duś-Ilnicka, Irena

doi:10.2478/ahem-2022-0016

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…In the estimation of p16 INK4A and HSV positivity in connection with the clinical diagnosis, statistical difference was shown among the overgrowth of mucosa samples when referring to the total number of positively diagnosed samples. Data from literature indicate the prevalence of HPV in the oral cavity ranging from 17.7% to 1.0% [ 31 , 41 ]. As described by Paver et al HPV positive squamous cell carcinoma arising in the head and neck region does not carry the favorable prognosis [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Duś-Ilnicka,

Hałoń,

Perra

et al. 2024

BMC Oral Health

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Background The association of Human Papilloma Virus (HPV) and Human Syncytial Virus (HSV) infection with inflammatory and potentially malignant disorders of the oral cavity (OPMD) is unknown. The aim of this cross-sectional study was to stablish the expression of the p16INK4A and HSV proteins, to test potential correlation between those parameters in biopsies from clinically diagnosed oral lesions. Methods Immunochemical analysis of 211 formalin-fixed, paraffin-embedded (FFPE) blocks from 211 individuals was provided. The clinical diagnosis included in the research were Oral lichen planus (N = 30), Oral Leukoplakia (N = 13) Mucocele (N = 25), Erosion/ulceration/ inflammation of mucosa (N = 8), Overgrowth of mucosa (N = 135). Results Two hundred eleven analyzed FFPE samples resulted with the median age of 58.5 years (the average age 54.0 years and SD ± 17 years). The female/male ratio was 2.3 (69.7% vs 30.3% respectively). All the samples positive for HSV also expressed p16INK4A (p = 0.000), that’s showed various levels of association with the diverse clinical diagnosis reaching the higher level in OM 49.1% (29 positive samples) and OLP 30.5% (18). p16INK4A was associated with OLP at 30.5% (18), and fibroma 30.5%. HSV expression was mostly present in fibroma at 47.6% (10 positive samples). Conclusion HSV and p16INK4A positivity in relation to diagnosis of the biopsies showed statistically most often p16INK4A in OLP and fibroma. The results of co-expression of p16INK4A and HSV in mucocele and fibroma in oral mucosa suggest a cooperation between the molecular alterations induced by these two viruses. Squamous papilloma samples positive for p16INK4A were also positive for HSV, suggesting that the putative pro-oncogenic action of HSV could be an early event.

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Section: Discussionmentioning

confidence: 99%

“…Since the infection with HSV and HPV represents the global burden [ 31 ], the aim of this study was to establish the prevalence of p16 INK4A surrogate marker for HPV and HSV in biopsies with the different clinical and histopathological diagnosis, taken from diverse oral mucosa sites, among them OPMD’s.…”

Section: Introductionmentioning

confidence: 99%

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Duś-Ilnicka,

Hałoń,

Perra

et al. 2024

BMC Oral Health

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“…33 Various HPV-associated diseases in the oral cavity, such as squamous papilloma, verruca vulgaris, condyloma acuminatum, Heck's disease, leukoplakia, lichen planus, and squamous cell carcinoma, do not produce oral vesicles or ulcerations but mainly keratinized verrucopapillary lesions. 34 Currently, COVID-19 remains an overwhelming pandemic throughout the globe. Coincidentally, monkeypox has become spreading out in many non-endemic regions.…”

Section: Discussionmentioning

confidence: 99%

Oral manifestations of monkeypox: Brief review

Iamaroon¹

2022

Dent. Med. Probl.

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The current outbreak of monkeypox infection has caught the attention of people worldwide. Updated data showed a dramatic increase in the number of patients in many non-endemic countries. An emergence of monkeypox together with coronavirus disease 2019 (COVID-19) caused a tremendous burden on the healthcare system, globally.The aim of this review was to briefly describe the current situation, transmission, clinical features, diagnosis, and prevention of the disease. Oral manifestations of monkeypox as well as those of similar viral diseases were elaborately delineated.The outbreak of monkeypox in non-endemic regions has expanded to at least 47 countries with more than 4,100 new infections. The clinical features in non-endemic regions are atypical and different from those in central and western Africa. Milder symptoms with no death cases have been observed. The oral mucosa is often involved and oral lesions may initially be manifested before the rash spreads to the face and other parts of the body. The diagnosis of monkeypox is mainly based on clinical presentations and laboratory investigations. Prevention by avoiding close contacts with patients and sick animals and providing vaccination to those who have a primary contact with patients is essential.Oral manifestations may occur prior to skin eruptions, suggesting that dentists and dental personnel should be well aware of the nature of the disease. Prevention and public awareness of the disease are crucial for mitigating further human-to-human transmission.

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“…Oral leukoplakia, which is the most common multifactorial premalignant lesion of the oral mucosa, may be induced by the inveterate use of tobacco in either smoked or smokeless form [ 114 ]; it has been shown that tobacco users have higher epithelial expression of MMPs, which imply their involvement in tobacco carcinogenesis [ 115 ]. High-risk human papillomavirus (HR-HPV) infection may be another cause of leukoplakia and carcinoma development [ 116 , 117 , 118 ]; HR-HPV E6 and E7 oncoproteins have an impact on cell homeostasis through inactivation of the p53 and pRB tumor suppressors, which leads to cellular immortalization [ 114 ], but it is not enough to explain the occurrence of cancer. Modification of the ECM by MMPs may represent another factor necessary for the establishment and progression of tumors [ 119 ].…”

Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

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The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular network present within all tissues and organs, forming the foundation on which cells sit, and composed of proteins (such as collagen), glycosaminoglycans, proteoglycans, minerals, and water. The ECM provides a fundamental framework for the cellular constituents of tissue and biochemical support to surrounding cells. The ECM is a highly dynamic structure that is constantly being remodeled. Matrix metalloproteinases (MMPs) are among the most important proteolytic enzymes of the ECM and are capable of degrading all ECM molecules. MMPs play a relevant role in physiological as well as pathological processes; MMPs participate in embryogenesis, morphogenesis, wound healing, and tissue remodeling, and therefore, their impaired activity may result in several problems. MMP activity is also associated with chronic inflammation, tissue breakdown, fibrosis, and cancer invasion and metastasis. The periodontium is a unique anatomical site, composed of a variety of connective tissues, created by the ECM. During periodontitis, a chronic inflammation affecting the periodontium, increased presence and activity of MMPs is observed, resulting in irreversible losses of periodontal tissues. MMP expression and activity may be controlled in various ways, one of which is the inhibition of their activity by an endogenous group of tissue inhibitors of metalloproteinases (TIMPs), as well as reversion-inducing cysteine-rich protein with Kazal motifs (RECK).

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Salivary HPV infection in healthy people

Cited by 5 publications

References 25 publications

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Oral manifestations of monkeypox: Brief review

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

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