Salivary Hydrogen Sulfide Measured with a New Highly Sensitive Self-Immolative Coumarin-Based Fluorescent Probe

Zaorska, Ewelina; Konop, Marek; Ostaszewski, Ryszard; Koszelewski, Dominik; Ufnal, Marcin

doi:10.3390/molecules23092241

Cited by 21 publications

(16 citation statements)

References 61 publications

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“…Hydrogen sulfide and mercaptans are the principal end products [ 38 ]. In healthy volunteers, the concentration of H 2 S in saliva was within a range of 1.641–7.124 μM [ 61 ]. In other studies, the mean amount of H 2 S in the saliva of healthy persons was 0.5 ng/10 mL, whereas in patients with IOH it was 6.7 ng/10 mL [ 62 ].…”

Section: Volatile Compoundsmentioning

confidence: 99%

The Role of Oral Microbiota in Intra-Oral Halitosis

Hampelska

Jaworska

Babalska

et al. 2020

JCM

102

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Halitosis is a common ailment concerning 15% to 60% of the human population. Halitosis can be divided into extra-oral halitosis (EOH) and intra-oral halitosis (IOH). The IOH is formed by volatile compounds, which are produced mainly by anaerobic bacteria. To these odorous substances belong volatile sulfur compounds (VSCs), aromatic compounds, amines, short-chain fatty or organic acids, alcohols, aliphatic compounds, aldehydes, and ketones. The most important VSCs are hydrogen sulfide, dimethyl sulfide, dimethyl disulfide, and methyl mercaptan. VSCs can be toxic for human cells even at low concentrations. The oral bacteria most related to halitosis are Actinomyces spp., Bacteroides spp., Dialister spp., Eubacterium spp., Fusobacterium spp., Leptotrichia spp., Peptostreptococcus spp., Porphyromonas spp., Prevotella spp., Selenomonas spp., Solobacterium spp., Tannerella forsythia, and Veillonella spp. Most bacteria that cause halitosis are responsible for periodontitis, but they can also affect the development of oral and digestive tract cancers. Malodorous agents responsible for carcinogenesis are hydrogen sulfide and acetaldehyde.

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Section: Volatile Compoundsmentioning

confidence: 99%

The Role of Oral Microbiota in Intra-Oral Halitosis

Hampelska

Jaworska

Babalska

et al. 2020

JCM

102

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“…Farago et al have recently developed a fibre optic fluorescence sensor for the detection of blood in saliva (Farago et al 2019 ). Coumarin based Fluorescent probes have been used for the detection of hydrogen sulphide in human saliva (Zaorska et al 2018 ).…”

Section: Optical Spectroscopy Techniques For Salivamentioning

confidence: 99%

“…SERS with PCA-LDA; non-invasive detection of NPC 2016 [Qiu et al 2016 ] 86.7% 21 SPR Recombinant human matrix metalloproteinases-9 (MMP-9); tumor progression and metastasis; saliva 2016 [Mohseni et al 2016 ] L.O.D : 8 pg/ml 22 SERS Breast cancer 2015 [Feng et al 2015 ] Malignant 74.19% 23 HPLC-LIF Various cancers 2015 [Patil et al 2015 ] L.O.D : femto-moles 24 AAS. Copper, iron, zinc and manganese in oral submucous fibrosis 2015 [Okade et al 2015 ] _ 25 Fluorescence Oral Cancer 2014 [Yuvaraj et al 2014 ] Emission spectra sensitivity 85.7% 26 Fluorescence Quantum Dots in Breast Cancer 2014 [Jokerst et al] L.O.D CEA: 0.02 ng/ml 27 HPLC-LIF Salivary protein markers; Oral cancer 2018 [Zaorska et al 2018 ] 79% 28 SPR Carbohydrate antigen 15-3 (CA15-3) in saliva 2012 [Liang et al 2012 ] L.O.D : 2.5 U/ml 29 SERS Saliva lung cancer 2011 [Li et al 2011 ] 94% 30 Optical Cancers 2008 [Tan et al 2011] L.O.D IL-8: 4 fM 31 SERS 5-fluorouracil: Chemotherapy drug; for solid tumors and colorectal carcinoma 2008 [Farquharson et al 2008 ] L.O.D: 2 μg/ml 32 SERS 5-Fluorouracil: Chemotherapy drug; for solid tumors and colorectal carcinoma 2005 [Farquharson et al 2005 ] ...…”

Section: Summary and Future Prospectsmentioning

confidence: 99%

Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections

Lukose

Mithun

et al. 2021

Biophys Rev

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Human saliva can be treated as a pool of biological markers able to reflect on the state of personal health. Recent years have witnessed an increase in the use of optical devices for the analysis of body fluids. Several groups have carried out studies investigating the potential of saliva as a non-invasive and reliable clinical specimen for use in medical diagnostics. This brief review aims to highlight the optical technologies, mainly surface plasmon resonance (SPR), Raman, and Fourier transform infrared (FTIR) spectroscopy, which are being used for the probing of saliva for diverse biomedical applications. Advances in bio photonics offer the promise of unambiguous, objective and fast detection of abnormal health conditions and viral infections (such as COVID-19) from the analysis of saliva.

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“…Worth to note the concentration of H 2 S in saliva is in the low micromolar range (1–7 μMol), i.e. the highest known (Zaorska et al 2018 ). It serves to activate salivary carbonic anhydrase (Bhakta et al 2016 ) and in turn to regulate the salivary-gastric recirculation of nitrites/NO (Aamand et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The role of host defences in Covid 19 and treatments thereof

Dattilo¹

2020

Mol Med

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Hydrogen sulfide (H2S) is a natural defence against the infections from enveloped RNA viruses and is likely involved also in Covid 19. It was already shown to inhibit growth and pathogenic mechanisms of a variety of enveloped RNA viruses and it was now found that circulating H2S is higher in Covid 19 survivors compared to fatal cases. H2S release is triggered by carbon monoxide (CO) from the catabolism of heme by inducible heme oxygenase (HO-1) and heme proteins possess catalytic activity necessary for the H2S signalling by protein persulfidation. Subjects with a long promoter for the HMOX1 gene, coding for HO-1, are predicted for lower efficiency of this mechanism. SARS-cov-2 exerts ability to attack the heme of hemoglobin and other heme-proteins thus hampering both release and signalling of H2S. Lack of H2S-induced persulfidation of the KATP channels of leucocytes causes adhesion and release of the inflammatory cytokines, lung infiltration and systemic endothelial damage with hyper-coagulability. These events largely explain the sex and age distribution, clinical manifestations and co-morbidities of Covid-19. The understanding of this mechanism may be of guidance in re-evaluating the ongoing therapeutic strategies, with special attention to the interaction with mechanical ventilation, paracetamol and chloroquine use, and in the individuation of genetic traits causing increased susceptibility to the disruption of these physiologic processes and to a critical Covid 19. Finally, an array of therapeutic interventions with the potential to clinically modulate the HO-1/CO/H2S axis is already available or under development. These include CO donors and H2S donors and a boost to the endogenous production of H2S is also possible.

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Salivary Hydrogen Sulfide Measured with a New Highly Sensitive Self-Immolative Coumarin-Based Fluorescent Probe

Cited by 21 publications

References 61 publications

The Role of Oral Microbiota in Intra-Oral Halitosis

The Role of Oral Microbiota in Intra-Oral Halitosis

Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections

The role of host defences in Covid 19 and treatments thereof

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