Salivary IgA and IgG subclasses in oral mucosal diseases

Sistig, Suzana; Vučićević-Boras, Vanja; Lukač, Josip; Kusić, Zvonko

doi:10.1034/j.1601-0825.2002.20844.x

Cited by 58 publications

(94 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sistig et al [37] did not define difference between exacerbation and remission, but they found increased salivary levels of IgA in oral lichen planus.…”

Section: Discussionmentioning

confidence: 96%

“…Altrhough Sistig [19] demonstrated an increased lervel of salivary IgA and IgG in these patients, Van der Waal [23] did not confirm that assumption.…”

Section: Introductionmentioning

confidence: 87%

“…Sistig [19] says that salivary immunoglobulin levels may play a role in the pathogenesis of oral mucosal diseases, including lichen planus, or that they reflect clinical changes in these conditions. With reference to this issue, an increased level of serum IgA and IgG in patients with OLP has been found [20,21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Humoral Mechanisms in Etiology of Lichen Planus

Поповска¹,

Mitik²,

Grchevska³

et al. 2014

Prilozi

View full text Add to dashboard Cite

Aim: To examine the role of IgA, CIC and component C3 as indicators of humoral immune response in the etiopathogenesis of oral erosive lichen planus (OELP). Material and method:The study comprised 19 patients with OELP whose samples of blood, saliva and tissue were obtained after carefully taken medical history and clinical examination. Samples of oral mucosa were taken from the site of lesion, i.e. exclusively from buccal mucosa (1 cm in width and length), and from the deep epithelium as well as a segment from the lamina propria. Determination of immunoglobulins in serum and saliva, and determination of component C3, was done using the micro-elisa technique by Rook&Cameron, Engvall and Ulman. Determination of CIC in serum and mixed saliva was done with the PEG (polyethylene glycol) method. Determination of immunoglobulin A and component C3 in biopsy material was done with direct immunofluorescence. Results: Levels of immunoglobulin A in serum in OELP during exacerbation were decreased (1.04 ± 0.49 gr/l) and during remission increased (5.92 ± 0.62) in comparison with the control group (p < 0.001). Levels of CIC during exacerbation and remission were increased (p < 0.001), and component C3 levels were increased in both examined phases in the examined group compared with the control group (p < 0.05). Deposits of IgA were registered in one (5.88%) patient with OELP and component C3 was registered in 3 (17.64%) patients. Conclusion: Changes in IgA values, as well as CIC and component C3, may correlate with changes in oral mucosa emphasizing the role of humoral immune response in the pathogenesis of oral lichen planus.

show abstract

“…Sistig et al [37] did not define difference between exacerbation and remission, but they found increased salivary levels of IgA in oral lichen planus.…”

Section: Discussionmentioning

confidence: 96%

“…Altrhough Sistig [19] demonstrated an increased lervel of salivary IgA and IgG in these patients, Van der Waal [23] did not confirm that assumption.…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Role of Humoral Mechanisms in Etiology of Lichen Planus

Поповска¹,

Mitik²,

Grchevska³

et al. 2014

Prilozi

View full text Add to dashboard Cite

show abstract

“…A IgA também tem a capacidade de neutralizar vírus presentes dentro de células epiteliais que expressam o receptor pIgR, pois quando a IgA se liga ao receptor e é transportada através da célula, ela se liga à proteína do vírus, impedindo sua replicação 19 . O signifi cado clínico sIgA ainda não está totalmente esclarecido, entretanto as avaliações de indivíduos com lesões mucosas orais, associadas aos conhecimentos teóricos e experimentos laboratoriais, sugerem que suas taxas salivares regulam o aparecimento e duração de lesões orais ou refl etem as alterações fi sopatológicas decorrentes dessas lesões 11,30 .…”

Section: Funções Da Sigaunclassified

“…O principal anti corpo presente nas mucosas e glândulas exócrinas é uma IgA polimérica, denominada IgA secretora (sIgA) [6][7][8] . Na mucosa bucal a sIgA representa a mais importante barreira imunológica, impedindo a aderência e penetração de microorganismos 4 e tem sido uti lizada como parâmetro do status imunológico dessa mucosa [9][10][11][12][13] . Devido à importância da sIgA na proteção da mucosa bucal e sua ampla uti lização na literatura como parâmetro de resposta imunológica, o presente trabalho tem como objeti vo revisar a literatura a respeito da produção, secreção e função desta imunoglobulina na proteção imunológica da mucosa bucal.…”

Section: Introductionunclassified

O Papel da Imunoglobulina A Secretora no Mecanismo de Defesa da Mucosa Bucal

Campos¹,

Ferreira²,

Vitral³

2011

Pesq Bras Odontoped Clin Integr

View full text Add to dashboard Cite

RESUMO ABSTRACTImunoglobulina A secretora; Sistema imune; Mucosa bucal. Immunoglobulin A, secretory; Immune system; Oral mucosa. DESCRITORES KEYWORDSIntrodução: As superfí cies mucosas mantêm contato direto com o meio externo, sendo expostas a uma grande variedade de antí genos. Essas superfí cies possuem relati va vulnerabilidade e a secreção de anti corpos pelo sistema imune de mucosa consti tui sua principal defesa, mantendo os antí genos desconhecidos e/ou potencialmente patogênicos fora do organismo. Entre esses anti corpos, o mais abundante é uma IgA polimérica, denominada IgA secretora, que é produzida por plasmócitos associados às mucosas e glândulas exócrinas. A sIgA possui uma estrutura capaz de resisti r à degradação proteolíti ca de enzimas bacterianas e digesti vas, o que a torna ideal para proteção do trato gastrointesti nal. Na mucosa bucal a sIgA representa a mais importante barreira imunológica, impedindo a aderência e a penetração de microorganismos, sendo uti lizada como parâmetro do status imunológico dessa mucosa. Objeti vo: Realizar uma revisão de literatura a respeito da imunoglobulina A secretora liberada na saliva, enfocando sua formação, secreção e as principais funções imunológicas na proteção da mucosa bucal. Conclusão: A imunoglobulina A secretora possui óti mas característi cas para a proteção da mucosa bucal, atribuídas à sua estrutura e ação específi ca e inespecífi ca. Os resultados de estudos clínico/laboratoriais associados a sua grande quanti dade salivar, sugerem uma parti cipação relevante da sIgA nos processos eti ológicos e fi siopatológicos de lesões na mucosa bucal, evidenciando a necessidade de uma maior atenção às funções dessa imunoglobulina em estudos posteriores.Introducti on: Mucosa surfaces are in direct contact with the external environment, being exposed to a great variety of anti gens. These surfaces have relati ve vulnerability and the secreti on of anti bodies by the mucosal immune system is the main defense mechanism, maintaining unknown and/ or potenti ally pathogenic anti gens out of the organism. Among these anti bodies, the most abundant is a polymeric IgA, denominated secretory immunoglobulin A (sIgA), which is produced by plasmocytes associated with mucosas and exocrine glandules. A sIgA has a structure capable of resisti ng to the proteolyti c degradati on of bacterial and digesti ve enzymes, which makes it ideal for protecti ng the gastrointesti nal tract. In the oral mucosa, sIgA represents the most important immunological barrier, impeding the adherence and penetrati on of microorganisms and being used as a parameter of immunological status of the mucosa. Objecti ve: This paper presents a literature review on the sIgA released in the saliva, focusing on its formati on, secreti on and the main immunological functi ons on the protecti on of the oral mucosa. Conclusion: sIgA has excellent characteristi cs for protecti ng the oral mucosa, which are att ributed to its structure and specifi c and unspecifi c acti ons. The results of clinical/laboratorial...

show abstract