Salivary IgA antibody responses to Streptococcus mitis and Streptococcus mutans in preterm and fullterm newborn children

Nogueira, Ruchele Dias; Sesso, Maria Lucia Talarico; Borges, Mariana Castro Loureiro; Mattos-Graner, Renata O.; Smith, Daniel J.; Ferriani, Virgínia Paes Leme

doi:10.1016/j.archoralbio.2011.11.011

Cited by 39 publications

(44 citation statements)

References 27 publications

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“…Caries susceptibility is inversely related to the output of salivary IgA in children and young adults [139]. Indeed, salivary IgA antibody titers against S. mutans are inversely related to levels of early oral colonization and the colonized individual’s caries experience; the mechanistic immunogenic target of these relationships are the bacterial adhesins, glucosyltransferases (GTF), and glucan-binding proteins (GBP) [140,141]. These antibody specificities are not unexpected, given the life-long presence of mutans streptococci in the oral biofilm.…”

Section: Caries Microbiome and Immunitymentioning

confidence: 99%

The oral microbiome and the immunobiology of periodontal disease and caries

2014

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The composition of the oral microbiome differs from one intraoral site to another, reflecting in part the host response and immune capacity at each site. By focusing on two major oral infections, periodontal disease and caries, new principles of disease emerge. Periodontal disease affects the soft tissues and bone that support the teeth. Caries is a unique infection of the dental hard tissues. The initiation of both diseases is marked by an increase in the complexity of the microbiome. In periodontitis, pathobionts and keystone pathogens such as Porphyromonas gingivalis appear in greater proportion than in health. As a keystone pathogen, P. gingivalis impairs host immune responses and appears necessary but not sufficient to cause periodontitis. Historically, dental caries had been causally linked to Streptococcus mutans. Contemporary microbiome studies now indicate that singular pathogens are not obvious in either caries or periodontitis. Both diseases appear to result from a perturbation among relatively minor constituents in local microbial communities resulting in dysbiosis. Emergent consortia of the minor members of the respective microbiomes act synergistically to stress the ability of the host to respond and protect. In periodontal disease, host protection first occurs at the level of innate gingival epithelial immunity. Secretory IgA antibody and other salivary antimicrobial systems also act against periodontopathic and cariogenic consortia. When the gingival immune response is impaired, periodontal tissue pathology results when matrix metalloproteinases are released from neutrophils and T cells mediate alveolar bone loss. In caries, several species are acidogenic and aciduric and appear to work synergistically to promote demineralization of the enamel and dentin. Whereas technically possible, particularly for caries, vaccines are unlikely to be commercialized in the near future because of the low morbidity of caries and periodontitis.

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Section: Caries Microbiome and Immunitymentioning

confidence: 99%

The oral microbiome and the immunobiology of periodontal disease and caries

2014

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“…This feature is a characteristic of the IgA repertoire of human neonates (Rogosch et al, 2012), as also reflected in neonatal secretions such as saliva (Nogueira et al, 2012). This situation is followed postnatally by a slow immune maturation with an SHM frequency of IgA V H gene transcripts up to 25% of the adult level at around 5 months of age (Rogosch et al, 2012).…”

Section: Immunological Memory and Mucosal Homeostasismentioning

confidence: 98%

The Mucosal B Cell System

Brandtzæg

2015

Mucosal Immunology

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“…Salivary sIgAl and sIgA2 specific to S. mitis and S. salivarius components increase qualitatively and quantitatively during the first few years of life [28]. Salivary IgA specific to components of streptococci that require hard surfaces for colonization (e.g., S. sanguis and mutans streptococci) generally appear after tooth eruption [29]. The maternal placental-derived IgG with specificity toward oral microbiota is replaced by the de novo synthesis stimulated by the teething process.…”

Section: Host Defense Mechanismsmentioning

confidence: 99%

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

Lazăr¹,

Dițu²,

Curuţiu³

et al. 2017

Periodontitis - A Useful Reference

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Oral cavity represents an ideal environment for the microbial cell growth, persistence, and dental plaque establishment. The presence of different microniches leads to the occurrence of different biofilm communities, formed on teeth surface, above gingival crevice or at subgingival level, on tongue, mucosa and dental prosthetics too. The healthy state is regulated by host immune system and interactions between microbial community members, maintaining the predominance of "good" microorganisms. When the complexity and volume of biofilms from the gingival crevice increase, chronic pathological conditions such as gingivitis and periodontitis can occur, predisposing to a wide range of complications. Bacteria growing in biofilms exhibit a different behavior compared with their counterpart, respectively planktonic or free cells. There have been described numerous mechanisms of differences in antibiotic susceptibility of biofilm embedded cells. Resistance to antibiotics, mediated by genetic factors or, phenotypical, due to biofilm formation, called also tolerance, is the most important cause of therapy failure of biofilm-associated infections, including periodontitis; the mechanisms of tolerance are different, the metabolic low rate and cell's dormancy being the major ones. The recent progress in science and technology has made possible a wide range of novel approaches and advanced therapies, aiming the efficient management of periodontal disease.

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Salivary IgA antibody responses to Streptococcus mitis and Streptococcus mutans in preterm and fullterm newborn children

Abstract: These data provide evidence that children have salivary IgA antibodies shortly after birth, which might influence the establishment of the oral microbiota, and that the levels of salivary antibody might be related to prematurity.

Cited by 39 publications

References 27 publications

The oral microbiome and the immunobiology of periodontal disease and caries

The oral microbiome and the immunobiology of periodontal disease and caries

The Mucosal B Cell System

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

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