Salivary IgA deficiency in a patient with cystic fibrosis (genotype M470V/V520F)

Oh, Jessica; McGarry, David; Joseph, Nancy; Peppers, Brian P.; Hostoffer, Robert

doi:10.1016/j.anai.2018.07.003

Cited by 4 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Conversely, saliva IgA deficiency, with | 2843 normal serum IgA levels was described in an adult CF patient with gastrointestinal symptoms. 17 Further, Nazaryan et al 35 They found the decrease of sIgA levels by 1.36-1.57 times in saliva in three different CFTR mutation groups compared to healthy children. In present study, patients with CF were controlled by a pediatrician and they did not have any infection.…”

Section: Discussionmentioning

confidence: 93%

“…Besides, increased Pa ‐specific IgA in both saliva and serum was observed in chronically infected adult CF patients 31 . Conversely, saliva IgA deficiency, with normal serum IgA levels was described in an adult CF patient with gastrointestinal symptoms 17 . Further, Nazaryan et al 35 They found the decrease of sIgA levels by 1.36–1.57 times in saliva in three different CFTR mutation groups compared to healthy children.…”

Section: Discussionmentioning

confidence: 96%

“…1,[10][11][12] Further, oral hygiene habit, plaque composition, saliva composition, frequently antibiotic therapy has importance for inflammation process both on dental hard tissues and periodontal tissues. [13][14][15][16] In an adult CF patient sIgA deficiency was also reported, 17 while in another study salivary IgA between the children with CF and healthy controls was not differing. 18 In an up-to-date qualitative systematic review on caries prevalence in children and adolescents with CF, future research in pediatric dentistry addressing the oral health of pediatric patients with CF was recommended in 2013.…”

Section: Introductionmentioning

confidence: 91%

“…Further, oral hygiene habit, plaque composition, saliva composition, frequently antibiotic therapy has importance for inflammation process both on dental hard tissues and periodontal tissues 13–16 . In an adult CF patient sIgA deficiency was also reported, 17 while in another study salivary IgA between the children with CF and healthy controls was not differing 18 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Özler

Duruel

Pınar

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

Purpose: To evaluate the caries status of the Cystic fibrosis (CF) children and adolescents with the comparation of some biochemical markers, secretoryimmunoglobulin-A (sIgA), and antimicrobial peptides in the saliva. Methods:In this cross-sectional descriptive study, the approval Ethics Board was obtained. Unstimulated saliva samples were collected from CF and healthy control children (non-CF) patients. Both groups underwent the same dental and periodontal evaluation scheme of the assessment. Human beta defensin (HBD1), human alpha defensin (HNP-1), cathelicidin (LL-37), sIgA in saliva were evaluated by enzymelinked immunoassay method. A general biochemical analysis was performed.Statistical analysis was performed by using Statistical Package for the Social Sciences Version 20.0 (SPSS Inc.).Results: A total of 21 (9 male, 12 female) CF and 23 (11 male, 12 female) control patients were participated with the mean age of 10.17 ± 3.38 and 9.52 ± 2.15 years, respectively. In control children, DMFT/S (decayed-missing-filled-tooth/surface-inpermanent-dentition), dmft/s (decayed-missing-filled-tooth/surface-in-primarydentition) values were higher; DT (decayed-tooth in permanent dentition), ft (filled-tooth in primary dentition) and plaque index values were statistically significantly higher (p = 0.042, p = 0.005, p = 0.038, respectively) than CF patients. Bicarbonate was higher in control group; sodium, chloride, and total protein were higher in CF group; magnesium, calcium and phosphate levels were similar in each group (p > 0.05). Alpha and beta defensin-1 levels in control group was statistically significantly higher (p = 0.037 and p = 0.020, respectively), while LL37 and sIgA were not statistically significantly higher (p > 0.05) than CF group.Conclusions: Children with CF had lower caries in permanent teeth, filling in primary teeth, and an altered salivary biomarker profile, especially in HNB1, HNP1. Therefore, it is important to conduct periodic oral-dental controls among CF patients during their childhood.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Özler

Duruel

Pınar

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Specific anti- Pseudomonas aeruginosa IgA has also been shown to be upregulated in serum when patients suffer from chronic infection [ 113 ] or poor pulmonary function [ 114 ], but also in sputum [ 115 ] and nasal secretion [ 116 ]. However, other studies showed decreased IgA secretion in CF saliva [ 117 ] and gastric luminal perfusate [ 118 ]. In CF research on therapies, pIgR was also used to transport alpha-1 antitrypsin into the lumen of the bronchi [ 119 ].…”

Section: Immunoglobulin a Mucosal Immunity In The Cf Respiratory Epitheliummentioning

confidence: 99%

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis

Gohy

Moeremans

Pilette

et al. 2021

Cells

View full text Add to dashboard Cite

The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and excessive inflammation. We aimed in this review to summarize respiratory mucosal alterations within the epithelium and current knowledge on local immunity linked to immunoglobulin A in patients with cystic fibrosis.

show abstract

Lung immunoglobulin A immunity dysregulation in cystic fibrosis

et al. 2020

View full text Add to dashboard Cite

Background In cystic fibrosis (CF), recurrent infections suggest impaired mucosal immunity but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-IgA is generated following polymeric immunoglobulin receptor (pIgR)-mediated transepithelial transport of dimeric (d-)IgA and represents a major defence through neutralisation of inhaled pathogens like Pseudomonas aeruginosa ( Pa ). Methods Human lung tissue (n = 74), human sputum (n = 118), primary human bronchial epithelial cells (HBEC) (cultured in air-liquid interface) (n = 19) and mouse lung tissue and bronchoalveolar lavage were studied for pIgR expression, IgA secretion and regulation. Findings Increased epithelial pIgR immunostaining was observed in CF lung explants, associated with more IgA-producing plasma cells, sputum and serum IgA, especially Pa -specific IgA. In contrast, pIgR and IgA transport were downregulated in F508del mice, CFTR-inhibited HBEC, and CF HBEC. Moreover, the unfolded protein response (UPR) due to F508del mutation, inhibited IgA transport in Calu-3 cells. Conversely, pIgR expression and IgA secretion were strongly upregulated following Pa lung infection in control and F508del mice, through an inflammatory host response involving interleukin-17. Interpretation A complex regulation of IgA secretion occurs in the CF lung, UPR induced by CFTR mutation/dysfunction inhibiting d-IgA transcytosis, and Pa infection unexpectedly unleashing this secretory defence mechanism. Funding This work was supported by the Forton's grant of the King Baudouin's Foundation, Belgium, the Fondazione Ricerca Fibrosi Cistica, Italy, and the Fonds National de la Recherche Scientifique, Belgium.

show abstract

Salivary IgA deficiency in a patient with cystic fibrosis (genotype M470V/V520F)

Cited by 4 publications

References 8 publications

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis

Lung immunoglobulin A immunity dysregulation in cystic fibrosis

Contact Info

Product

Resources

About