Salivary IgA versus HIV and Dental Caries

Mandal, Pradip; Mitra, Malay; Acharya, Sonu; Ghosh, Chandra Kanta; Mohanty, Sandeep; Saha, Subrata

doi:10.7860/jcdr/2016/19394.8531

Cited by 5 publications

(33 citation statements)

References 29 publications

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“…For quantitative data assessment, a meta‐analysis was performed. Considering the total mean salivary IgA levels among HIV seropositive and seronegative children, only 4 studies presented data to be included in the meta‐analysis. Archibald et al reported per milligram of salivary albumin in median and 25th to 75th percentile; hence, this study was excluded from quantitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…The ĸ value of interreader agreement of the STROBE checklist was 0.94. All the included clinical studies in this systematic review were observational studies. The quality of 3 studies was regarded as high, since these studies received a score ≥ 7 with low risk of bias (Tables and ).…”

Section: Resultsmentioning

confidence: 99%

“…The results also showed an inverse relationship between the occurrence of angular chelitis and sIgA levels in the study population . Similarly, Mandal et al assessed the association between salivary IgA levels and dental caries status among 28 HIV‐positive children aged between 6 and 14 years and 28 age‐matched systemically healthy children (controls). The results showed that the scores of decayed missing filed teeth were significantly higher and salivary IgA levels were significantly lower in HIV‐positive children compared with controls .…”

Section: Introductionmentioning

confidence: 81%

“…Therefore, power calculation is an important methodological protocol in the design of a planned research design. It is noteworthy that only a limited number of studies (n = 6) with a relatively small number of participants (up to 80 participants) addressed our focused question . Upon a vigilant review of the studies included, it was noted that none of the studies included had estimated the study sample size based on a power calculation.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Mandal et al assessed the association between salivary IgA levels and dental caries status among 28 HIV‐positive children aged between 6 and 14 years and 28 age‐matched systemically healthy children (controls). The results showed that the scores of decayed missing filed teeth were significantly higher and salivary IgA levels were significantly lower in HIV‐positive children compared with controls . In conclusion, the authors suggested that children with salivary IgA deficiency are more susceptible to dental caries compared with controls.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Is salivary IgA level a potential biomarker for immunosuppression in HIV‐positive children? A systematic review and meta‐analysis

Javed

Akram

Binshabaib

et al. 2017

Reviews in Medical Virology

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The aim of this systematic review was to determine whether or not assessment of salivary secretory immunoglobulin A (sIgA) levels could be a potential biomarker for immunosuppression in HIV-positive children. The Patient, Exposure, Comparative, Outcome question was "Is sIgA level a potential biomarker for immunosuppression in HIV-positive children?" Electronic and manual literature searches were conducted in indexed databases (MEDLINE, PubMed, EMBASE, ScienceDirect, and SCOPUS databases) up to and including June 2017. The primary outcome was total mean salivary levels of IgA among HIV seropositive and seronegative children (controls). The weighted mean differences (WMD) of outcomes and 95% confidence intervals (CI) for total mean salivary IgA levels were calculated using a random effect model. Six studies were included. Three studies showed significantly lower salivary IgA levels in HIV-infected children compared with controls. Two studies showed comparable IgA levels in HIV infected and controls. One study showed significantly higher levels of salivary IgA in HIV-infected children as compared to controls. Considering the total mean salivary IgA levels among HIV seropositive and seronegative children, a high degree of heterogeneity (Q value = 254.09, P < .0001, I = 98.82%) was noticed among both groups. The overall WMD was not significant (WMD = -1.18, 95% CI, -1.91 to -0.44, P = .39). Whether salivary IgA level is a potential biomarker for immunosuppression in HIV-positive children remains debatable because of limited information available in the current literature. Further, high-quality case-control studies with larger sample size and more solid methodological aspects are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is salivary IgA level a potential biomarker for immunosuppression in HIV‐positive children? A systematic review and meta‐analysis

Javed

Akram

Binshabaib

et al. 2017

Reviews in Medical Virology

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Dental caries in HIV‐infected children and adolescents: A systematic review with meta‐analysis

et al. 2023

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This study aimed to evaluate and compare the risk of dental caries in between human immunodeficiency virus (HIV)‐infected and uninfected children and adolescents. An electronic search was performed on PubMed/MEDLINE, Web‐of‐Science, Scopus, LILACS, ProQuest, and ClinicalTrials.gov up to May 2022. The critical appraisal checklist developed by the Joanna Briggs Institute was used to evaluate the quality of the included studies. Meta‐analysis was performed using the RevMan 5.4. Sixteen studies were included. A total of 3231 participants were evaluated, including 1701 and 1530 HIV‐infected and uninfected children and adolescents, respectively. The meta‐analysis revealed a higher risk of dental caries for primary dentitions in HIV‐infected children and adolescents by decayed, missing, filled tooth (dmft) (SMD:0.34; p = 0.006) and decayed, missing, filled surface (dmfs) scores (SMD:0.37; p = 0.001). Similar results were observed for permanent dentition, with increased dental caries in HIV‐infected children and adolescents with DMFT (SMD:0.32; p = 0.003) and DMFS (SMD:1.78; p < 0.0001) scores. Regarding the quality assessment, most of the included studies were moderate or good quality. However, the certainty of the evidence of the outcomes was very low. This systematic review and meta‐analysis showed higher caries severity in permanent and deciduous teeth among HIV‐infected children and adolescents.

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Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

Berrezouga,

Kooli,

Marrakchi

et al. 2024

BMC Oral Health

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Background Studies regarding salivary biochemical parameters and dental caries in adult people living with HIV/AIDS (PLWHA) are scanty. Aim: To investigate salivary biochemical parameters and dental caries in adult PLWHA who are on antiretroviral therapy (ART) and compare the findings with people negative for HIV infection. Methods The study included 50 HIV positive individuals as a test group (TG) and 50 HIV negative individuals as a control group (CG). Dental examination was performed according to WHO guidelines to assess DMFT. Digital panoramic radiographs were taken to detect additional infectious foci. Non-stimulated saliva was collected between 9 and 12 a. m for 5 min to evaluate 18 biochemical parameters and salivary flow rate (SFR). Parametric and non parametric tests were used according to data distribution. The level of significance was set at p < 0.05%. Results Patients’ mean ages and M/F sex ratios for TG and CG were 38.80 ± 9.69 y/o. vs. 37.98 ± 13.47 y/o. and 3.54 vs. 2.33, respectively. Higher means of decayed teeth were recorded in TG, 4.47 ± 3.00 vs. 3.88 ± 2.81 in CG with no significant difference (p = 0.41). Means of filled teeth were significantly lower in TG 2.38 ± 2.16 vs. 4.16 ± 3.35 in CG (p = 0.01), respectively. No statistical significant difference was noted in DMFT indices between the 2 groups (8.04 ± 6.90 vs. 8.52 ± 6.24, p = 0.71). The following salivary parameters were significantly lower in TG compared to CG, respectively: mean SFR 0.44 ± 0.18 ml/min vs. 0.61 ± 0.26 ml/min; median levels of sodium and chlorides, 4 mmol/L and 13.5 mmol/L vs. 9 mmol/L and 19 mmol/L (p < 0.001) and uric acid, 103.50 mmol/L vs. 163 (p = 0.009). However, higher median levels were recorded with calcium, 1.09 mmol/L vs. 0.54 (p < 0.001) and sIgA 23 mg/dl vs. 5 mg/dl (p < 0.001). In TG, a positive correlation was found between DC, potassium, urea, and chlorides (p < 0.05). Salivary renal and hepatic biomarkers were comparable between the two groups. Conclusions PLWHA have shown an alteration in some salivary parameters, more decayed teeth and less filled teeth. Preventive measures should be implemented to lower dental caries and enhance accessibility to oral care services. In addition, saliva can be utilized to monitor oral and general health status among PLWHA on ART.

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Salivary IgA versus HIV and Dental Caries

Cited by 5 publications

References 29 publications

Is salivary IgA level a potential biomarker for immunosuppression in HIV‐positive children? A systematic review and meta‐analysis

Is salivary IgA level a potential biomarker for immunosuppression in HIV‐positive children? A systematic review and meta‐analysis

Dental caries in HIV‐infected children and adolescents: A systematic review with meta‐analysis

Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

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