Salivary Immunoglobulins and Prevalent Coronary Artery Disease

“…Исследование профиля биомаркеров слюны рассмат-ривается как перспективный метод оценки ФР и неинва-зивной диагностики широкого круга патологических со-стояний человека, включая болезнь Крона, синдром Шег-рена, панкреатит, рак поджелудочной железы, полости рта и молочной железы, ожирение, ССЗ [84][85][86]. Так, повы-шенное содержание в слюне IgА, коррелирующее с уров-нем СРБ и асимптомным поражением зубов, предложено рассматривать как возможный ФР ССЗ [87].…”

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Anti‐Tumor Necrosis Factor‐Alpha Therapy and Periodontal Parameters in Patients With Rheumatoid Arthritis

Mayer

Balbir‐Gurman

Machtei

2009

Journal of Periodontology

149

142

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Background: The aim of this study was to evaluate the influence of anti‐tumor necrosis factor‐alpha (TNF‐α) therapy on the clinical and immunologic parameters of the periodontium. Methods: Ten patients with rheumatoid arthritis (RA) who routinely received infusions of infliximab, 200 mg (RA+), 10 patients with RA without anti‐TNF‐α therapy (RA−), and 10 healthy controls (C) were included. Clinical parameters, including the plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (AL), and bleeding on probing (BOP), were assessed, and total gingival crevicular fluid (GCF) TNF‐α level was determined using enzyme‐linked immunosorbent assay. Analysis of variance with Scheffe modification and the Pearson correlation test were used for statistical analysis. Results: The ages of the patients ranged from 22 to 76 years (mean, 50.73 ± 9.1 years). The mean PI was similar among the groups. However, mean inflammatory parameters in the three groups varied significantly; GI was greater in the RA− group compared to RA+ and C groups (P = 0.0042). The RA+ group exhibited less BOP than RA− and C groups (21.1% ± 3.0%, 45.9% ± 6.2%, and 39.1% ± 7.2%, respectively; P = 0.0146). The mean PD in the RA+ group was shallower than in RA− and C groups (3.22 ± 0.13 mm, 3.85 ± 0.22 mm, and 3.77 ± 0.20 mm, respectively; P = 0.055). Clinical AL in the RA+ group was lower than in RA− and C groups (3.68 ± 0.11 mm, 4.52 ± 0.26 mm, and 4.35 ± 0.24 mm, respectively; P = 0.0273). TNF‐α levels in the GCF of the RA+ group were the lowest compared to RA− and C groups (0.663, 1.23, and 0.949 ng/site, respectively; P = 0.0401). A significant positive correlation was found between TNF‐α levels in the GCF and clinical AL (r = 0.448; P = 0.0283). Conclusions: Patients with RA receiving anti‐TNF‐α medication had lower periodontal indices and GCF TNF‐α levels. Thus, suppression of proinflammatory cytokines might prove beneficial in suppressing periodontal diseases.

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“…This latter observation taken together with the previous literature suggest several mechanisms by which low sIgA and high IgA might both relate to mortality; low sIgA might indicate impaired immunity with ageing, which in turn influences both infectious disease risk and cancer risk, whereas high serum IgA may indicate already underlying disease. Nevertheless, it should also be noted that in some instances, abnormally high sIgA levels indicate current acute oral infection [ 7 ], and inflammation [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Salivary Immunoglobulin A Secretion Rate Is Negatively Associated with Cancer Mortality: The West of Scotland Twenty-07 Study

2015

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Immunoglobulins are essential for combating infectious disease although very high levels can indicate underlying pathology. The present study examined associations between secretory immunoglobulin A (sIgA) in saliva and mortality rates in the general population. Participants were 639 adults from the eldest cohort of the West of Scotland Twenty-07 Study aged 63 years at the time of saliva sampling in 1995. From unstimulated 2-minute saliva samples, saliva volume and S-IgA concentration were measured, and S-IgA secretion rate determined as their product. Mortality data were tracked for 19 years. Cox proportional hazard models were applied to compute hazard ratios (HR) for all-cause mortality from sIgA secretion rate. Associations were adjusted for gender, assay batch, household occupational group, smoking, medication usage, and self-reported health. There was a negative association between log sIgA secretion rate and all-cause mortality, HR = 0.81, 95%CI = 0.73–0.91, p < .001. Further analysis of specific causes of mortality revealed that the all-cause association was due to an underlying association with cancer mortality and in particular with cancers other than lung cancer. The HR for non-lung cancer was 0.68 (95%CI = 0.54 to 0.85) implying a 32% reduction in mortality risk per standard deviation rise in log sIgA secretion rate. Effects were stronger for men than women. For deaths from respiratory diseases, sIgA secretion had a non-linear relationship with mortality risk whereby only the very lowest levels of secretion were associated with elevated risk. SIgA concentration revealed a similar but weaker pattern of association. In the present study, higher secretion rates of sIgA were associated with a decreased risk of death from cancer, specifically non-lung cancer, as well as from respiratory disease. Thus, it appears that sIgA plays a protective role among older adults, and could serve as a marker of mortality risk, specifically cancer mortality.

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Salivary Immunoglobulins and Prevalent Coronary Artery Disease

Cited by 15 publications

References 28 publications

Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population

Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population

Anti‐Tumor Necrosis Factor‐Alpha Therapy and Periodontal Parameters in Patients With Rheumatoid Arthritis

Salivary Immunoglobulin A Secretion Rate Is Negatively Associated with Cancer Mortality: The West of Scotland Twenty-07 Study

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