Salivary immunoglobulins: Normal adult values and dissociation between serum and salivary levels

Claman, Henry N.; Merrill, Deborah A.; Hartley, T. F.

doi:10.1016/0021-8707(67)90004-4

Cited by 61 publications

(15 citation statements)

References 15 publications

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“…Strong correlations over time have been reported for parotid saliva densitometric patterns (Oberg et al, 1982), stimulated parotid saliva concentrations of total protein, lysozyme, lactoferrin, and peroxidase , and unstimulated whole saliva concentrations of amylase, total protein, lysozyme, lactoferrin, peroxidase, and slgA Jenzano et al, 1987;Rudney et al, 1993). There is some uncertainty regarding the stability of slgA, since studies have reported conflicting results (Claman et al, 1967;Stuchell and Mandel, 1978;Burgio et al, 1980;Widerstrom and Bratthall, 1984;Bratthall and Widerstrom, 1985;Rudney et al, , 1993. This may be partly an artifact of sample size, since total slgA has been correlated over time in studies involving larger numbers of subjects (Bratthall and Widerstrom, 1985;Gleeson et al, 1991;Rudney etal, 1993).…”

Section: (B) Longitudinal Variationmentioning

confidence: 99%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

114

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Salivary protein interactions with oral microbes in vitro include aggregation, adherence, cell-killing, inhibition of metabolism, and nutrition. Such interactions might be expected to influence oral ecology. However, inconsistent results have been obtained from in vivo tests of the hypothesis that quantitative variation in salivary protein concentrations will affect oral disease prevalence. Results may have been influenced by choices made during study design, including saliva source, stimulation status, control for flow rate, and assay methods. Salivary protein concentrations also may be subject to circadian variation. Values for saliva collected at the same time of day tend to remain consistent within subjects, but events such as stress, inflammation, infection, menstruation, or pregnancy may induce short-term changes. Long-term factors such as aging, systemic disease, or medication likewise may influence salivary protein concentrations. Such sources of variation may increase the sample size needed to find statistically significant differences. Clinical studies also must consider factors such as human population variation, strain and species differences in protein-microbe interactions, protein polymorphism, and synergistic or antagonistic interaction between proteins. Salivary proteins may form heterotypic complexes with unique effects, and different proteins may exert redundant effects. Patterns of protein-microbe interaction also may differ between oral sites. Future clinical studies must take those factors into account. Promising approaches might involve meta-analysis or multi-center studies, retrospective and prospective longitudinal designs, short-term measurement of salivary protein effects, and consideration of individual variation in multiple protein effects such as aggregation, adherence, and cell-killing.

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Section: (B) Longitudinal Variationmentioning

confidence: 99%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

114

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“…Other investigators (1,2,18) The parallel medial lemniscal and anterolateral components of the spinal somatic sensory pathways, although activated by "tactile" stimulation of the skin, do not contribute equally to sensory discriminative functions (1). This is true also for the homologues of these pathways in the brainstem trigeminal complex.…”

mentioning

confidence: 99%

Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency

Brandtzæg

Fjellanger

Gjeruldsen

1968

Science

140

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“…Previous quantitative studies on salivary immunoglobulins in normal subjects have yielded variable results [3]. Wide ranges for IgA levels are quoted, and most previous investigators have failed to detect measurable IgG or IgM [5]. To date, the methods for salivary immunoglobulin as says have been unsatisfactory, usually lacking sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Salivary Immunoglobulins in Sjögren's Syndrome

Bluestone¹,

Gumpel²,

Goldberg³

et al. 1972

Int Arch Allergy Immunol

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Using a new electro-immunodiffusion assay, serum and salivary immunoglobulin levels were measured in patients with SjÖgren’s syndrome (SS) and in normal control subjects. Salivary IgG levels were generally higher in the patients (mean 17.3 mg%, SEM 1.7) compared to normals (mean 12.1 mg%, SEM 1.3), the higher values usually correlating with elevated serum IgG levels. Salivary IgA levels were similar in both groups – a mean of 10.3 mg%, SEM 2.5 in normals and 8.9 mg%, SEM 2.0 in the patients. In the latter group much of the salivary IgA was secretory IgA; absolute levels of secretory IgA ranged from 2.5 to 6.4 mg% (mean 4.4). No measurable levels of IgM were detected in the salivas of patients or normal subjects, although IgM was demonstrated by immunofluorescence in labial gland biopsies from two patients. Four patients had serum anti-salivary duct antibodies, but none had this autoantibody in their saliva. Thus, patients with SS retain competence of the salivary immune system even in the advanced stages of their disease.

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Salivary immunoglobulins: Normal adult values and dissociation between serum and salivary levels

Cited by 61 publications

References 15 publications

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency

Salivary Immunoglobulins in Sjögren's Syndrome

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