Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: The Suita study

Kosaka, Takayuki; Kokubo, Yoshihiro; Ono, Takahiro; Sekine, Shinichi; Kida, Momoyo; Kikui, Miki; Yamamoto, Masaaki; Watanabe, Makoto; Amano, Atsuo; Maeda, Yoshinobu; Miyamoto, Yoshihiro

doi:10.1016/j.atherosclerosis.2014.08.046

Cited by 37 publications

(37 citation statements)

References 28 publications

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“…Salivary IL-6 is strongly related to oral health, including chronic conditions such as periodontitis and oral cancer (Nibali, Fedele, D'Aiuto, & Donos, 2012). Furthermore, recent research in an urban Japanese cohort study (Kosaka et al, 2014) revealed an association between salivary IL-6 and atherosclerosis, implying a role for oral inflammation in CVD. Overall, it is clear that the current results have implications for gay men's health as they confront the damaging effects of prejudice and discrimination.…”

Section: Discussionmentioning

confidence: 99%

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Doyle

Molix

2016

J Behav Med

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Physical health disparities by sexual orientation are widespread yet under-investigated. Drawing upon theories of biological embedding of social adversity, we tested whether minority stress (in the form of perceived discrimination) is associated with salivary interleukin-6 (IL-6), an inflammatory mediator. Furthermore, we examined whether covering, a strategy involving downplaying a stigmatized social identity, modified this association. A community sample (N = 99) of gay men (n = 78) and lesbian women (n = 21) completed self-report measures of minority stress and identity management and provided saliva samples which were assayed for IL-6. Among gay men, results from generalized linear models supported a hypothesized interaction between perceived discrimination and covering, such that perceived discrimination was predictive of higher levels of IL-6 for those who engaged in less covering but not for those who engaged in more covering. This interaction was robust to a number of potential covariates (alcohol, medication, body mass index, race and age). Results for lesbian women suggested a different pattern: the only statistically significant association detected was between greater perceived discrimination and lower levels of IL-6. Findings from the current study point to an important role for inflammatory processes in understanding and remediating health disparities based upon sexual orientation that stem from exposure to prejudice and discrimination.

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Section: Discussionmentioning

confidence: 99%

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Doyle

Molix

2016

J Behav Med

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“…Kosaka et al 29 found that levels of salivary inflammatory cytokines including IL-1β, IL-6, TNF-α and prostaglandin E2 increased significantly in both atherosclerosis and periodontal diseases. These cytokines might be potential biomarkers for the diagnosis of periodontal disease and atherosclerosis.…”

Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

“…These cytokines might be potential biomarkers for the diagnosis of periodontal disease and atherosclerosis. 29 Miller et al 30 identified that the C-reactive protein (CRP) was the most predictive biomarker of acute myocardial infarction. Acute myocardial infarction was predicted by a combination of electrocardiogram and CRP levels with 80.0% sensitivity and 100% specificity.…”

Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

Saliva in the diagnosis of diseases

et al. 2016

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Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.

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“…Some epidemiological studies have investigated the risk factors of CA. 8–10 However, only a few epidemiological studies have researched Chinese populations, and data on the population from Northeast China in particular is limited. The climate and eating habits in Northeast China vary widely from those in South China: it is much colder, with more lipid intake in daily meals.…”

Section: Introductionmentioning

confidence: 99%

Factors Significantly Associated With the Increased Prevalence of Carotid Atherosclerosis in a Northeast Chinese Middle-aged and Elderly Population

Pan

Lai

et al. 2016

Medicine

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Carotid atherosclerosis is associated with many serious cardiovascular diseases; hence, it is necessary to identify factors related to its occurrence in order to develop preventive and therapeutic strategies. This study was conducted to identify risk factors associated with carotid atherosclerosis among the population residing in Northeast China.This epidemiological survey was conducted in a representative group of relatively healthy community residents. All participants answered questions about their medical histories and underwent physical examination, blood biochemical analysis, and ultrasonography examinations of their necks and abdomens. The prevalence rates of carotid atherosclerosis under different factors and conditions were then analyzed.The results of this study showed that age, gender, and diabetes significantly affected the prevalence of carotid atherosclerosis in this Northeast Chinese population. In addition, gender-based subgroup analysis revealed additional factors correlated with the prevalence of carotid atherosclerosis in men or women, although their correlations were not significant in the overall population. While high serum TC and LDL-C levels were risk factors for carotid atherosclerosis in men, it showed no clear correlation with the prevalence of carotid atherosclerosis in women. In contrast, the prevalence of carotid atherosclerosis in female participants with high serum TG level, hypertension, obesity and nonalcoholic fatty liver disease were higher than that of the control population, a trend not observed in male participants.Older age, male sex, and diabetes were independently associated with increased risk of carotid atherosclerosis in Northeast China. These findings could lead to improved screening for carotid atherosclerosis for better disease management.

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Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: The Suita study

Cited by 37 publications

References 28 publications

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Saliva in the diagnosis of diseases

Factors Significantly Associated With the Increased Prevalence of Carotid Atherosclerosis in a Northeast Chinese Middle-aged and Elderly Population

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