Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls

Shigeyama, Chieko; Ansai, Toshihiro; Awano, Shuji; Soh, Inho; Yoshida, Akihiro; Hamasaki, Tomoko; Kakinoki, Yasuaki; Tominaga, Kazuhiro; Takahashi, Tsuneo; Takehara, Tadamichi

doi:10.1016/j.tripleo.2008.07.005

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…The salivary flow rate is used to aid in the diagnosis of oral and systemic diseases [6]. For these purposes, it is important to understand the different aspects of saliva secretion in healthy people, including its kinetics and the influencing factors.…”

Section: Introductionmentioning

confidence: 99%

“…A number of studies have focused on the evaluation of the salivary secretion in healthy people during stress responses to acute mental stress [2], [12], [13]. However, the data on the influence of mental stress on the salivary flow rate have not indicated the presence of a specific influence [12], increased salivary flow rate [2] or reduced salivary flow rate [6].…”

Section: Introductionmentioning

confidence: 99%

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Acute Short-Term Mental Stress Does Not Influence Salivary Flow Rate Dynamics

et al. 2012

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Background: Results of studies that address the influence of stress on salivary flow rate and composition are controversial. The aim of this study was to reveal the influence of stress vulnerability and different phases of stress reactivity on the unstimulated and stimulated salivary flow rate. We examined that acute mental stress does not change the salivary flow rate. In addition, we also examined the salivary cortisol and protein level in relation to acute mental stress stimuli. Methods: Saliva of male subjects was collected for five minutes before, immediately, 10, 30 and 120 min after toothbrushing. Before toothbrushing, the subjects were exposed to acute stress in the form of a 2 min public speech. Salivary flow rate and total protein was measured. The physiological stress marker cortisol was analyzed using enzyme-linked immunosorbent assay. To determine the subjects' psychological stress reaction, the State-Trait-Anxiety Inventory State questionnaire (STAI) data were obtained. The subjects were divided into stress subgroup (S1) (psychological reactivity), stress subgroup (S2) (psychological and physiological reactivity) and a control group. The area under the curve for salivarycortisol concentration and STAI-State scores were calculated. All data underwent statistical analysis using one-way analysis of variance. Results: Immediately after stress exposure, all participants exhibited a psychological stress reaction. Stress exposure did not change the salivary flow rate. Only 69% of the subjects continued to display a physiological stress reaction 20 minutes after the public talk. There was no significant change in the salivary flow rate during the psychological and the physiological stress reaction phases relative to the baseline. Conclusions: Acute stress has no impact on the salivary flow rate; however, there may be other responses through salivary proteins that are increased with the acute stress stimuli. Future studies are needed to examine specific proteins and their possible roles in acute stress responses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Short-Term Mental Stress Does Not Influence Salivary Flow Rate Dynamics

et al. 2012

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“…Our study design is obviously not sufficient to allow an exploration of causal relationships, but some data do suggest that chronic stress has a direct impact on saliva production and may lead to chronic xerostomia [38,39]. Salivary levels of cortisol and chromogranin A have been found to be increased in subjects with low salivary flow rates [40]. Profound alterations in neurotransmitter homeostasis in SS were long ago observed by Santavirta et al [41]; both the vasoactive intestinal peptide and the neuropeptide Y contents (markers of parasympathetic and sympathetic nervous system activity, respectively) in the saliva were found to differ from those in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Neuroimmune Interactions in Sjögren’s Syndrome: Relationship of Exocrine Gland Dysfunction with Autoantibodies to Muscarinic Acetylcholine Receptor-3 and Mental Health Status Parameters

Deák¹,

Szvetnik

Balog³

et al. 2012

Neuroimmunomodulation

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Objectives: Antimuscarinic acetylcholine receptor-3 (m3AChR) autoantibodies have been described in primary Sjögren’s syndrome (pSS). The aim of this study was to compare various methods for their detection and to assess the contributions of anti-m3AChR and other immunological and psychosocial factors to the pathomechanism of secondary SS (sSS). Methods: Sixty-five rheumatoid arthritis (RA) patients, 103 systemic lupus erythematosus (SLE) patients, 76 pSS patients and 50 controls were compared. Three immunodominant epitopes of m3AChR were synthesized and used in ELISA. Two extracellular epitopes were also prepared in fusion with glutathione-S-transferase and one in conjugation with bovine serum albumin. Mental health status was assessed with the 36-item Short-Form Health Survey and Functional Assessment of Chronic Illness Therapy fatigue scale. Correlations were evaluated between glandular function and anti-m3AChR positivities and specificities, features of SLE and RA, and mental health parameters. Results: Fourteen RA and 27 SLE patients had sSS. The autoantibody levels to all epitopes of m3AChR were significantly higher in pSS and SLE patients than in the controls. The fusion protein forms discriminated RA from pSS and SLE; furthermore, the YNIP fusion protein also distinguished pSS from SLE. The prevalence and the mean levels of all autoantibodies did not differ statistically between sicca and non-sicca SLE or RA patients. Glandular dysfunction correlated with higher age in SLE and RA and an impaired health-related quality of life in SLE. Conclusions: The second and third extracellular loops of m3AChR are antigenic in pSS. Immunoassays with antigens as fusion peptides demonstrate the best performance. Sicca SLE patients have worse mental health status. Anti-m3AChR antibodies represent a peculiar example of neuroimmune interactions.

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“…Likewise, no significant differences were found between groups regarding the levels of salivary CHGA and the presence of xerostomia. On the contrary, Shigeyama et al [33] reported that individuals with dry mouth had increased salivary levels of CHGA compared with those without dry mouth. These data can be explained by the presence of only three individuals in our control group with xerostomia.…”

Section: Discussionmentioning

confidence: 93%

“…infecção periodontal) exacerbam a resposta do hospedeiro, contribuindo para a aceleração do desenvolvimento da resistência à insulina e, consequentemente, o aparecimento do DM2 e suas complicações. Alguns estudos já demonstram o efeito favorável da terapia periodontal no controle metabólico de pacientes diabéticos pobremente controlados (28)(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Introductionunclassified

Concentração e perfil genético da Cromogranina A e a sua correlação com os aspectos salivar, dental e status periodontal : um estudo transversal em portadores de diabetes mellitus tipo 2

Kogawa¹

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Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls

Cited by 27 publications

References 25 publications

Acute Short-Term Mental Stress Does Not Influence Salivary Flow Rate Dynamics

Acute Short-Term Mental Stress Does Not Influence Salivary Flow Rate Dynamics

Neuroimmune Interactions in Sjögren’s Syndrome: Relationship of Exocrine Gland Dysfunction with Autoantibodies to Muscarinic Acetylcholine Receptor-3 and Mental Health Status Parameters

Concentração e perfil genético da Cromogranina A e a sua correlação com os aspectos salivar, dental e status periodontal : um estudo transversal em portadores de diabetes mellitus tipo 2

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