Salivary Levels of α-Amylase &amp; Cortisol In Patients With Recurrent Aphthous Ulceration

Madkour, Gihane Gharib; Refaie, Ibrahim El

doi:10.21608/edj.2018.76816

Cited by 1 publication

(3 citation statements)

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“…26 Stress has also been documented as a triggering factor for the development of recurrent aphthous stomatitis, but the exact underlying mechanism remains unclear and controversial. 29 Onset of the ulcer may be attributed to elevated salivary cortisol levels in the saliva. 34 A more recent study showed that stressful life events were significantly associated with the onset of recurrent aphthous stomatitis episodes but not with the duration of the episodes.…”

Section: Discussionmentioning

confidence: 99%

“…7 Cortisol is a critical hormone in reaction to stress. 29 Stress can cause an increase in salivary cortisol levels and affect immunoregulatory activity causing inflammation by increasing the number and activity of leukocytes, causing various changes in the oral cavity. 30 In humans, stress and anxiety levels can be identified with free blood and salivary cortisol.…”

Section: Discussionmentioning

confidence: 99%

“…It mediates several vital functions, such as regulating carbohydrates, protein, and fat metabolism, maintaining vascular reactivity, and regulating blood cell numbers. 29 Although the pathogenesis is unclear, the continuous increases in cortisol levels under stressful conditions may lead to increased inflammatory activity by inducing immune dysfunction, which in turn triggers recurrent aphthous stomatitis with a higher chance of recurrence. 2 Epidemiological studies have suggested that emotional stress may be a precipitating factor for recurrent aphthous stomatitis.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Stress in Recurrent Aphthous Stomatitis

Nurdiana

Ritonga

Wulandari

2023

European Journal of General Dentistry

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Objectives This study aimed to determine the role of stress in recurrent aphthous stomatitis. Stress was examined with the Perceived Stress Scale and cortisol levels; meanwhile, recurrent aphthous stomatitis was assessed with the duration of the lesion. Materials and Methods This was a cross-sectional analytical study conducted at Oral Medicine Installation, Universitas Sumatera Utara Dental Hospital, and Prodia Laboratory, Medan. The subjects were 50 patients with minor recurrent aphthous stomatitis, without systemic disease, who did not take systemic drugs or use orthodontic appliances. The diagnosis of recurrent aphthous stomatitis was established with anamnesis and clinical examination. Stress was examined by filling out the Perceived Stress Scale questionnaire and blood tests for serum cortisol levels. Statistical analysis The data were analyzed using the Fisher test and Mann–Whitney U test. Results This study showed no significant relationship between the Perceived Stress Scale category and recurrent aphthous stomatitis, with a p-value of 0.392. This study also showed no significant relationship between blood cortisol level and recurrent aphthous stomatitis with a p-value of 1.000. Conclusion Stress may play an important role in recurrent aphthous stomatitis. However, this study did not show any difference in stress examined through the Perceived Stress Scale and cortisol levels based on the duration of recurrent aphthous stomatitis.

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Section: Discussionmentioning

confidence: 99%