Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study

Moreau, C; Habnouni, Chakib El; Lecron, Jean‐Claude; Morel, Franck; Delwail, Adriana; Garrec, Raphaële Le; Miséry, Laurent; Piver, Éric; Vaillant, L.; Lefèvre, Antoine; Emond, Patrick; Blasco, Hélène; Samimi, Mahtab

doi:10.1097/j.pain.0000000000002733

Cited by 6 publications

(4 citation statements)

References 98 publications

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“…Our findings are in line with other studies that have utilized salivary metabolomics to detect changes in metabolic pathways associated with various physiological conditions ( 10 , 21–23 ). In the context of swine reproduction, the development of early pregnancy biomarkers is of paramount importance.…”

Section: Discussionsupporting

confidence: 92%

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Ren,

Zhang,

et al. 2024

Front. Vet. Sci.

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In an effort to enhance reproductive management and reduce non-productive periods in swine breeding, this study presents a novel, non-invasive metabolomics approach for the identification of early pregnancy biomarkers in sows. Utilizing an untargeted metabolomics approach with mass spectrometry analysis, we examined saliva samples from pregnant (n = 6) and non-pregnant control sows (n = 6, artificially inseminated with non-viable sperm). Our analysis revealed 286 differentially expressed metabolites, with 152 being up-regulated and 134 down-regulated in the pregnant group. Among these, three metabolites, namely Hyodeoxycholic acid, 2′-deoxyguanosine, and Thymidine, emerged as potential early pregnancy biomarkers. These biomarkers were further evaluated using targeted LC–MS/MS quantification and qualification, accompanied by ROC curve analysis. The study confirmed Hyodeoxycholic acid and 2′-deoxyguanosine as promising biomarkers for early pregnancy detection, offering potential for future implementation in swine production environments. This research establishes a robust theoretical foundation for the development of innovative molecular diagnostic techniques and explores new avenues for molecular genetic breeding and non-invasive diagnostics, ultimately enhancing fertility and productivity in sow herds.

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Section: Discussionsupporting

confidence: 92%

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Ren,

Zhang,

et al. 2024

Front. Vet. Sci.

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“…Studies have shown that dopamine affects appetite by stimulating exocrine secretion and reducing gastrointestinal motility in the digestive system [ 36 ]. In the kidneys, dopamine increases sodium excretion and urine output, leading to frequent urination, whereas high dopamine levels can lead to hyperactivity, anxiety, hypersalivation, and digestive problems [ 37 , 38 ]. Normal concentrations of dopamine in blood vessels can inhibit the release of norepinephrine and act as a vasodilator [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Gas/Liquid Chromatography–Mass Spectrometry Analysis of Key Functional Substances Regulating Poll Gland Secretion in Male Camels during Seasonal Estrus

Dai

Yuan

Zhang

et al. 2023

Animals

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Increased poll gland secretion is a major characteristic and indicator of estrus in male Bactrian camels; however, research on these poll glands and their secretion is extremely rare. In this study, we determine the chemical composition of poll gland secretions and identify the key functional substances that regulate seasonal estrus in male camels. A GC/LC-MS dual platform was used to analyze ventral hair (control) and neck mane samples containing poll gland secretions from male Bactrian camels during estrus. Multidimensional and single-dimensional analyses were used to screen differentially expressed metabolites (DEMs) between groups. Functional prediction of enriched metabolites was performed using a Human Metabolome Database comparison and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, which were then compared with a behavioral analysis of male Bactrian camels in estrus. A total of 1172 DEMs and 34 differential metabolic pathways were identified. One metabolite group was found to relate to steroid synthesis and metabolism, and another metabolite group was associated with neural metabolism. Therefore, we speculate that steroids and neurochemicals jointly regulate estrous behavior in male Bactrian camels, thus providing theoretical insights into the development and function of poll glands in Bactrian camels.

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“…(c) Do not meet the diagnosis of other diseases in the Third International Classification of Headache 2 . The pain is continuous and mild to severe in intensity although it may fluctuate, being often better in the morning and aggravating towards the evening, but it only rarely disturbs sleep 19 3 . Who were willing to participate to the study and could finish the survey of Visual Analogue Scale, Self‐Rating Depression Scale and self‐rating anxiety scale.…”

Section: Methodsmentioning

confidence: 99%

The over‐expression of miRNA‐206 in peripheral blood of patients with burning mouth syndrome and its relationship with anxiety and depression

Fang

Huang

et al. 2023

J of Oral Rehabilitation

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Background: Burning mouth syndrome (BMS) is characterised by persisting burning pain of the oral mucosa, and its etiopathogenesis remains poorly understood.Objectives: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients.Methods: Thirty patients with BMS and 30 healthy individuals were enrolled in the experimental and control groups, respectively. Data on medical history and clinical oral examination for all participants were collected. Simultaneously, scores of Visual Analogous Scale (VAS), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were administered. The expression level of miRNA-206 in plasma were determined by RT-(q)PCR. Finally, the relationship of miRNA-206 expression with the VAS score, SAS score, and SDS score was analysed. Chi-square test and t-test were used for statistical analysis of the data, and p < .05 was considered statistically significant. Results:The majority of the patients with BMS identified the tongue as the main pain area, and showed dry mouth and poor sleep quality. The SAS and SDS scores of patients with BMS were higher than those of healthy controls (p < .05) and were positively correlated with VAS pain score. In addition, miRNA-206 expression was higher in patients with BMS than in healthy individuals (p < .05), and was positively correlated with the VAS and SDS scores (p < .05). Conclusions:Patients with BMS suffer from pain and tend to be more anxious and depressed than healthy controls. miRNA-206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS.

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Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study

Abstract: Supplemental Digital Content is Available in the Text.The observed shift in the tyrosine pathway in saliva of burning mouth syndrome patients may indicate an adaptative response to chronic pain or an impaired dopaminergic transmission.

Cited by 6 publications

References 98 publications

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

Gas/Liquid Chromatography–Mass Spectrometry Analysis of Key Functional Substances Regulating Poll Gland Secretion in Male Camels during Seasonal Estrus

The over‐expression of miRNA‐206 in peripheral blood of patients with burning mouth syndrome and its relationship with anxiety and depression

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