Salivary Microbiota Is Significantly Less Diverse in Patients with Chronic Spontaneous Urticaria Compared to Healthy Controls: Preliminary Results

Ćesić, Diana; Lugović-Mihić, Liborija; Ferček, Iva; Grginić, Ana Gverić; Jelić, Marko; Bešlić, Iva; Andrašević, Arjana Tambić

doi:10.3390/life11121329

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Treg cells can suppress pro-inflammatory cytokines mediated by various T-cells, including Th2 cells, and can induce the secretion of anti-inflammatory mediators, thereby reducing inflammation [ 14 ]. Reduced Treg cells have been observed in patients with CSU [ 64 , 65 , 66 ]. GPCRs are also expressed in mast cells, the key cells in the development of urticaria.…”

Section: Discussionmentioning

confidence: 99%

Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria

Ćesić

Lugović-Mihić

Ozretić

et al. 2023

Life

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(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as Lachnospiraceae, in skin inflammatory diseases. (2) Goal: This study aimed to compare the abundance of Lachnospiraceae between CSU patients and healthy controls (HCs). (3) Material and methods: In this case–control study, 16S rRNA sequencing was performed to compare the composition of the gut microbiome between 22 CSU patients and 23 HCs. (4) Results: Beta-diversity revealed significant clustering (p < 0.05) between the CSU patients and HCs. Alpha diversity in the CSU group was significantly decreased according to the Evenness index (p < 0.05). The linear discriminant analysis effect size (LEfSe) identified the significant depletion of the Lachnospiraceae family in CSU patients. (5) Conclusion: Our study revealed the dysbiosis of the gut microbiota in CSU patients, including decreased levels of Lachnospiraceae members, responsible for SCFA production, suggesting that SCFAs may contribute to immune dysfunction in the pathogenesis of CSU. We speculate that the modulation of SCFAs could serve as a prospective additional option in CSU treatment.

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Section: Discussionmentioning

confidence: 99%

Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria

Ćesić

Lugović-Mihić

Ozretić

et al. 2023

Life

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“…This study was based on previous research that found that the combination of the two above-mentioned probiotics may reduce the release of pro-Th-2 cytokines from THP-1 cells, favouring an improvement in Th1/Th2 [ 87 ]. Therefore, it should be mentioned that some Bifidobacterium species have useful anti-inflammatory effects; some strains (used as probiotics) improve dysbiosis and alleviate the inflammatory response, possibly by/through inducing Treg cells with their anti-inflammatory mediators [ 88 ].…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data

Krišto¹,

Lugović-Mihić²,

Muñoz

et al. 2023

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Recent studies have linked gut microorganism composition and chronic urticaria (CU); however, the underlying mechanisms responsible for this connection are unknown. Since the human immune system is in homeostasis with microbiota, and the composition of the microbiome regulates the development and function of the immune system, it is likely that an alteration of microbiota components (a dysbiosis) could influence the course of chronic spontaneous urticaria (CSU), including disease severity, patient quality of life and treatment outcome. To date, several studies have identified changes in the gut microbiota composition of patients with CSU, though only a few have exhibited metabolic abnormalities associated with gut dysbiosis. The studies on CSU patients predominantly showed that the relative abundance of beneficial bacteria was decreased (Firmicutes and Bacteroides), while that of opportunistic bacteria was increased (Enterobacteria and Proteobacteria). In addition, serum metabolome analysis revealed that gut microbiota-associated alterations in unsaturated fatty acids and the butanoate metabolism pathway may play a role in CSU. These findings are potentially associated with inflammation mediated by the imbalance of Th1/Th2/Th17 cytokines, which might contribute to CSU pathogenesis. Further research in this field could improve clinical, diagnostic, and therapeutic approaches to patients with CSU. By applying new knowledge on gut microbial communities and metabolomics, future CSU therapies could modify the microbiota composition using agents such as probiotics or other similar agents, which, in combination with current standard therapies, could hopefully lead to a reduction in symptoms and an improved quality of life for CSU patients.

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“…Increasing evidence suggested that changes in the gut microbiome can trigger skin inflammation ( Kim et al, 2020 ; Chun et al, 2021 ). It was worth noting that the 16S ribosomal RNA gene sequencing results showed that microbial composition was significantly different between urticaria patients and healthy individuals ( Lu et al, 2019 ; Ćesić et al, 2021 ; Wang et al, 2021 ; Zhang et al, 2021 ). Besides, a randomized placebo-controlled trial suggested adjunct therapy with probiotics was safe and effective at four weeks in treating chronic urticaria in children ( Bi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between gut microbiota and urticaria: a bidirectional two-sample mendelian randomization study

et al. 2023

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BackgroundCumulative evidence showed an association between gut microbiota and urticaria, but the causal relationship between them is unclear. We aimed to verify whether there is a causal relationship between the composition of gut microbiota and urticaria and explore whether the causal effect was bidirectional.MethodsWe obtained genome-wide association studies (GWAS) summary data of 211 gut microbiota and urticaria from the most extensive available GWAS database. A bidirectional two-sample mendelian randomization (MR) study was used to test the causal relationship between the gut microbiota and urticaria. The MR analysis was primarily performed with the inverse variance weighted (IVW) method, and MR-Egger, weighted median (WM), and MR-PRESSO were performed as sensitivity analyses.ResultsThe Phylum Verrucomicrobia (OR 1.27, 95%CI 1.01 to 1.61; p = 0.04), Genus Defluviitaleaceae UCG011 (OR 1.29, 95%CI 1.04 to 1.59; p = 0.02), and Genus Coprococcus 3 (OR 1.44, 95%CI 1.02 to 2.05; p = 0.04) was a risk effect against urticaria. And Order Burkholderiales (OR 0.68, 95%CI 0.49 to 0.99; p = 0.04) and Genus Eubacterium xylanophilum group (OR 0.78, 95%CI 0.62 to 0.99; p = 0.04) were negatively associated with urticaria, suggesting a protective effect. At the same time, urticaria had a positively causal effect on gut microbiota (Genus Eubacterium coprostanoligenes group) (OR 1.08, 95%CI 1.01 to 1.16; p = 0.02). These findings showed no influence by heterogeneity or horizontal pleiotropy. Moreover, most sensitivity analyses showed results consistent with those of IVW analysis.ConclusionOur MR study confirmed the potential causal relationship between gut microbiota and urticaria, and the causal effect was bidirectional. Nevertheless, these findings warrant further examination owing to the unclear mechanisms.

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Salivary Microbiota Is Significantly Less Diverse in Patients with Chronic Spontaneous Urticaria Compared to Healthy Controls: Preliminary Results

Cited by 7 publications

References 47 publications

Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria

Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria

Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data

Causal relationship between gut microbiota and urticaria: a bidirectional two-sample mendelian randomization study

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