Salivary neuropeptides, stress, and periodontitis

Haririan, Hady; Andrukhov, Oleh; Böttcher, Michael; Pablik, Eleonore; Wimmer, Gernot; Moritz, Andreas; Rausch‐Fan, Xiaohui

doi:10.1902/jop.2017.170249

Cited by 37 publications

(28 citation statements)

References 48 publications

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“…Thirdly, among the control group, periodontal patients had higher levels of serum CGRP in comparison with those without periodontitis. Contrary to these results, Haririan and co‐workers observed no differences in CGRP concentrations measured in both serum and saliva of patients with periodontitis and without periodontitis . However, another study showed that periodontally healthy sites showed increased gingival crevicular fluid concentrations of CGRP compared with sites with gingivitis or periodontitis (no detection of CGRP) .…”

Section: Discussionmentioning

confidence: 86%

Periodontal inflammation is related to increased serum calcitonin gene‐related peptide levels in patients with chronic migraine

Leira

Ameijeira

Domínguez

et al. 2019

Journal of Periodontology

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Background Recently, a relationship was found between periodontitis and chronic migraine. Calcitonin gene‐related peptide (CGRP) is a key element in migraine pathophysiology. However, no information exists of the potential association between periodontal inflammation and CGRP in chronic migraine. The aim of the study was, therefore, to investigate whether there is a link between periodontitis and peripheral levels of CGRP in a cohort of patients with chronic migraine. Methods We included 102 chronic migraineurs and 77 age‐ and sex‐matched individuals free of headache/migraine. Full‐mouth periodontal parameters were recorded and the periodontal inflamed surface area (PISA) was calculated to quantify the periodontal inflammatory status for each participant. Sociodemographic data and comorbidities were assessed by means of a standard questionnaire. We collected blood samples and serum concentrations were done for CGRP, interleukin (IL)‐6 and IL‐10. Results In the chronic migraine group, patients with periodontitis had greater levels of serum CGRP (19.7 ± 6.5 versus 15.3 ± 6.2 pg/mL, P < 0.0001) and IL‐6 (15.1 ± 9.2 versus 9.6 ± 6.3 pg/mL, P < 0.0001) while non‐significant differences were observed with IL‐10 (2.0 ± 1.0 versus 2.8 ± 1.5 pg/mL, P = 0.675) concentrations than those without periodontitis. PISA was independently associated with CGRP in patients with chronic migraine (β = 0.003; 95% confidence interval: 0.001 to 0.006, P = 0.031). PISA correlated positively with CGRP (r = 0.236; P = 0.017) and IL‐6 (r = 0.262; P = 0.008) in chronic migraine. Conclusions Periodontal inflammation is associated with increased circulating levels of CGRP in chronic migraineurs. Elucidating the exact mechanisms through which periodontitis and CGRP are linked in these patients deserves further investigation.

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Section: Discussionmentioning

confidence: 86%

Periodontal inflammation is related to increased serum calcitonin gene‐related peptide levels in patients with chronic migraine

Leira

Ameijeira

Domínguez

et al. 2019

Journal of Periodontology

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“…The EC system can be speculated to mediate a link between stress and periodontitis. Stress is a significant risk factor influencing the immune system and potentially contributing to the progression of periodontitis [46,47]. The EC system plays an essential role in the stress response [48].…”

Section: Discussionmentioning

confidence: 99%

Methanandamide diminish the Porphyromonas gingivalis lipopolysaccharide induced response in human periodontal ligament cells

et al. 2020

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Background: The endocannabinoid system is involved in the regulation of periodontal tissue homeostasis. Synthetic cannabinoid methanandamide (Meth-AEA) has improved stability and affinity to cannabinoid receptors compared to its endogenous analog anandamide. In the present study, we investigated the effect of methanandamide on the production of pro-inflammatory mediators in primary human periodontal ligament cells (hPdLCs). Methods: hPdLCs were treated with Meth-AEA for 24 h, and the resulting production of interleukin (IL)-6, IL-8, and monocyte chemotactic protein (MCP)-1 was measured in the absence or the presence of Porphyromonas gingivalis lipopolysaccharide (LPS). Additionally, the effect of Meth-AEA on the proliferation/ viability of hPdLCs was measured by the MTT method. Results: Methanandamide at a concentration of 10 μM significantly inhibited P. gingivalis LPS induced production of IL-6, IL-8, and MCP-1. Basal production of IL-6 and IL-8 was slightly enhanced by 10 μM Meth-AEA. No effect of Meth-AEA on the basal production of MCP-1 was observed. Meth-AEA in concentrations up to 10 μM did not affect the proliferation/viability of hPdLCs, but significantly inhibited it at a concentration of 30 μM. Conclusion: Our study suggests that the inflammatory response in periodontal ligament cells could be influenced by the activation of the cannabinoid system, which might be potentially involved in the progression of periodontal disease.

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“…EC system can be speculated to mediate a link between stress and periodontitis. Stress is a significant risk factor influencing immune system and potentially contributing to the progression of periodontitis [46,47]. EC system plays an essential role in the stress response [48].…”

Section: Discussionmentioning

confidence: 99%

Methanandamide diminish the Porphyromonas gingivalis lipopolysaccharide induced response in human periodontal ligament cells

Zhang

Özdemir

Nguyen

et al. 2020

Preprint

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Background: The endocannabinoid system is involved in the regulation of periodontal tissue homeostasis. Synthetic cannabinoid methanandamide (Meth-AEA) has improved stability and affinity to cannabinoid receptors compared to its endogenous analog anandamide. In the present study, we investigated the effect of methanandamide on the production of pro-inflammatory mediators in primary human periodontal ligament cells (hPdLCs).Methods: hPdLCs were treated with Meth-AEA for 24 h, and the resulting production of interleukin (IL)-6, IL-8, and monocyte chemotactic protein (MCP)-1 was measured in the absence or the presence of Porphyromonas gingivalis lipopolysaccharide (LPS). Additionally, the effect of Meth-AEA on the proliferation/viability of hPdLCs was measured by MTT method. Results: Methanandamide at a concentration of 10 µM significantly inhibited P. gingivalis LPS induced production of IL-6, IL-8, and MCP-1. Basal production of IL-6 and IL-8 was slightly enhanced by 10 µM Meth-AEA. No effect of Meth-AEA on the basal production of MCP-1 was observed. Meth-AEA in concentrations up to 10 µM did not affect the proliferation of hPdLCs, but significantly inhibited it at a concentration of 30 µM. Conclusion: Our study suggests that the inflammatory response in periodontal ligament cells could be influenced by the activation of the cannabinoid system, which might be potentially involved in the progression of periodontal disease.

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Salivary neuropeptides, stress, and periodontitis

Abstract: VIP and NPY in saliva could be potential gender-specific salivary biomarkers for periodontitis regardless of psychological stress.

Cited by 37 publications

References 48 publications

Periodontal inflammation is related to increased serum calcitonin gene‐related peptide levels in patients with chronic migraine

Periodontal inflammation is related to increased serum calcitonin gene‐related peptide levels in patients with chronic migraine

Methanandamide diminish the Porphyromonas gingivalis lipopolysaccharide induced response in human periodontal ligament cells

Methanandamide diminish the Porphyromonas gingivalis lipopolysaccharide induced response in human periodontal ligament cells

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