Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study

Jong, Trynke R. de; Menon, Rohit; Bludau, Anna; Grund, Thomas; Biermeier, Verena; Klampfl, Stefanie M.; Jurek, Benjamin; Bosch, Oliver J.; Hellhammer, Juliane; Neumann, Inga D.

doi:10.1016/j.psyneuen.2015.08.027

Cited by 207 publications

(191 citation statements)

References 47 publications

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“…The trend toward an increase in CORT associated with either OXT treatment or recovery from a stressor in the presence of a partner was not robust. However, the lack of an OXT- or partner-induced reduction in CORT, together with our anatomical data, is not in line with the widely discussed hypothesis, drawn from research in rats (Petersson et al, 1999; Windle et al, 2004, 1997; Babygirija et al, 2012; Blume et al, 2008; Bülbül et al, 2011; Jurek et al, 2015; Zheng et al, 2010), mice made mutant for OXT (Amico et al, 2008), prairie voles (Smith et al, 2015; Smith and Wang, 2014), and humans (Heinrichs et al, 2003; Jong et al, 2015), that OXT and social support exert protective effects primarily by buffering against activation of the HPA axis. Instead, our data suggest that when presented with a stressor that calls for physical and energetic mobilization, administration of exogenous OXT does not prevent what could be an adaptive rise in glucocorticoid levels.…”

Section: Discussioncontrasting

confidence: 89%

Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Yee

Kenkel

Frijling

et al. 2016

Hormones and Behavior

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The neuropeptide oxytocin (OXT) facilitates prosocial behavior and selective sociality. In the context of stress, OXT also can down-regulate hypothalamic–pituitary–adrenal (HPA) axis activity, leading to consideration of OXT as a potential treatment for many socioaffective disorders. However, the mechanisms through which administration of exogenous OXT modulates social behavior in stressful environmental contexts are not fully understood. Here, we investigate the hypothesis that autonomic pathways are components of the mechanisms through which OXT aids the recruitment of social resources in stressful contexts that may elicit mobilized behavioral responses. Female prairie voles (Microtus ochrogaster) underwent a stressor (walking in shallow water) following pretreatment with intraperitoneal OXT (0.25 mg/kg) or OXT antagonist (OXT-A, 20 mg/kg), and were allowed to recover with or without their sibling cagemate. Administration of OXT resulted in elevated OXT concentrations in plasma, but did not dampen the HPA axis response to a stressor. However, OXT, but not OXT-A, pretreatment prevented the functional coupling, usually seen in the absence of OXT, between paraventricular nucleus (PVN) activity as measured by c-Fos immunoreactivity and HPA output (i.e. corticosterone release). Furthermore, OXT pretreatment resulted in functional coupling between PVN activity and brain regions regulating both sympathetic (i.e. rostral ventrolateral medulla) and parasympathetic (i.e. dorsal vagal complex and nucleus ambiguous) branches of the autonomic nervous system. These findings suggest that OXT increases central neural control of autonomic activity, rather than strictly dampening HPA axis activity, and provides a potential mechanism through which OXT may facilitate adaptive and context-dependent behavioral and physiological responses to stressors.

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Section: Discussioncontrasting

confidence: 89%

Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Yee

Kenkel

Frijling

et al. 2016

Hormones and Behavior

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“…This test, which includes components of public speaking component and oral mental arithmetic, produces a robust increase in CORT and self-reported psychological stress and these effects are attenuated by OT (Heinrichs et al 2003; Quirin et al 2011; Simeon et al 2011; de Oliveira et al 2012; Kubzansky et al 2012). Consistent with an OT anti-stress hypothesis, a recent study that measured both OT and CORT after the TSST found that salivary OT levels increased immediately following social stress exposure, prior to increases in salivary CORT (Jong et al 2015). Taken together, these data suggest that OT treatment may be useful to normalize the HPA-axis and reduce stress-related physiological and subjective responses (e.g., anxiety, craving) that increase drug and alcohol use and trigger relapse.…”

Section: Oxytocin and Stressmentioning

confidence: 78%

Oxytocin for the treatment of drug and alcohol use disorders

Lee

Weerts

2016

Behavioural Pharmacology

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There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and other substance use disorders. OT is a neuropeptide that modulates adaptive processes associated with addiction including reward, tolerance, associative learning, memory, and stress responses. OT exerts its effects via interactions with the hypothalamic–pituitary–adrenal (HPA) axis, and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. Oxytocin effects on stress systems are of high interest given the strong link between stress, drug use and relapse, and known dysregulation of HPA-axis activity associated with substance use disorders. At the same time, the oxytocin system is itself altered by acute or chronic drug exposure. This review summarizes the preclinical and clinical literature on the oxytocin system, and its relevance to drug and alcohol addiction. In addition, findings from recent clinical trials conducted in participants with cocaine, cannabis or alcohol use disorder are included and evidence that oxytocin may help to normalize blunted stress responses, and attenuate withdrawal associated hypercortisolism, negative mood and withdrawal symptoms are summarized.

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“…This indirect effect could possibly be due to the fact that OXT might buffer the stress reactivity associated with a reduction of cortisol secretion (Cardoso et al, 2014;de Jong et al 2015). An alternative or complementary pathway of the cortisol mediation is that OXT and AVP influence anxiety and stress through pathways within the brain.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

Jämsen

Johansson

Westberg

et al. 2017

J Speech Lang Hear Res

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Purpose: Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single nucleotide polymorphisms (SNP) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol since oxytocin and vasopressin associated with cortisol levels.Method: A population based sample (N = 657) of Finnish twins (born 1961-1989) completed a web-questionnaire on the occurrence of vocal symptoms. A total of (n = 170) participants submitted saliva samples for hormone analysis. A total of 20 OXTR and AVPR1A SNPs were analyzed.Results: Three OXTR polymorphisms (rs2270465, rs2268493, rs7632287) and two AVPR1A polymorphisms (rs1587097, rs1042615) showed nominal effects (p < .05) on vocal symptoms, of which one (rs1587097) remained significant after correcting for multiple testing (p = .003). We found potential mediation of the effect of the OXTR rs2268493 polymorphism on vocal symptoms through levels of cortisol.Conclusions: The associations between variants of OXTR and AVPR1A and vocal symptoms indicate that oxytocin and vasopressin might influence vocal symptoms. The effect of oxytocin seems to be partly mediated through cortisol actions.

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Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study

Cited by 207 publications

References 47 publications

Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Oxytocin for the treatment of drug and alcohol use disorders

Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

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