Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis

Finamore, Alberto; Peluso, Ilaria; Cauli, Omar

doi:10.3390/ijms21228562

Cited by 20 publications

(18 citation statements)

References 88 publications

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“…Finamore et al demonstrated a link between saliva and intestinal profiles in patients with inflammatory bowel diseases (IBD), and this result suggests that, even in athletes, saliva sampling can also be used as a biomarker for gut disease in the oral–gut axis [ 23 ].…”

Section: The Oral Ecosystem and The Saliva Diagnostic Functionmentioning

confidence: 99%

The Impact of Sport Training on Oral Health in Athletes

et al. 2021

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Athletes’ oral health appears to be poor in numerous sport activities and different diseases can limit athletic skills, both during training and during competitions. Sport activities can be considered a risk factor, among athletes from different sports, for the onset of oral diseases, such as caries with an incidence between 15% and 70%, dental trauma 14–70%, dental erosion 36%, pericoronitis 5–39% and periodontal disease up to 15%. The numerous diseases are related to the variations that involve the ecological factors of the oral cavity such as salivary pH, flow rate, buffering capability, total bacterial count, cariogenic bacterial load and values of secretory Immunoglobulin A. The decrease in the production of S-IgA and the association with an important intraoral growth of pathogenic bacteria leads us to consider the training an “open window” for exposure to oral cavity diseases. Sports dentistry focuses attention on the prevention and treatment of oral pathologies and injuries. Oral health promotion strategies are needed in the sports environment. To prevent the onset of oral diseases, the sports dentist can recommend the use of a custom-made mouthguard, an oral device with a triple function that improves the health and performance of athletes. During training, the sports dentist must monitor the athletes and the sports examination protocol must be implemented with the inclusion of the clinical examination, quantitative and qualitative analysis of saliva and instructions on the use, cleansing and storage of the mouthguard.

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Section: The Oral Ecosystem and The Saliva Diagnostic Functionmentioning

confidence: 99%

The Impact of Sport Training on Oral Health in Athletes

et al. 2021

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“…In recent years, the changes in expression levels and expression patterns of salivary proteins under different disease states and physiological conditions have made them an essential breakthrough in studying the etiology, diagnosis and prognosis of these diseases (Zian et al, 2018;Finamore et al, 2020;Tvarijonaviciute et al, 2020). Changes in salivary protein in states of different blood glucose levels have become a hot spot in the study of the relationship between the oral cavity and diabetes (Bencharit et al, 2013;Lima-Aragão et al, 2016).…”

Section: Analysis Of the Discriminating Ability Of Candidate Proteinsmentioning

confidence: 99%

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Jia

Zhang

Sun

et al. 2021

Front. Mol. Biosci.

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Type 2 diabetes mellitus (T2DM) is an increasing global public health concern, but its impact on the salivary proteome is still unclear. To evaluate the effect of glycemic levels in middle-aged and elderly individuals with T2DM on salivary proteomics, we compared the differences by liquid chromatography tandem mass spectrometry (LC–MS/MS). Unstimulated whole saliva samples from 8 T2DM patients with good glycemic control (G group, HbA1c <6.5%) and 16 patients with poor control (P group, HbA1c ≥6.5%) were analyzed by LC–MS/MS in the data-independent acquisition mode (Clinical register number: ChiCTR1900023582.). After functional annotation, cluster analysis and receiver operating characteristic (ROC) curve analysis were carried out to screen and evaluate candidate proteins. A total of 5,721 proteins were quantified, while 40 proteins differed significantly. In the P group, proteins involved in oxidative stress-related processes were upregulated, whereas proteins related to salivary secretion were downregulated. The combination of thioredoxin domain-containing protein 17, zymogen granule protein 16B, and FAM3 metabolism regulating signaling molecule D yielded an area under the curve of 0.917 which showed a robust ability to distinguish the P and G groups. In conclusion, poorly controlled hyperglycemia may affect salivary proteins through various pathways, including oxidative stress and glandular secretion. Furthermore, the differentially expressed proteins, especially the three proteins with the best differentiation, might serve as an anchor point for the further study of hyperglycemia and oral diseases.

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“…Lipid peroxidation, the oxidative damage of membrane lipids, unless disrupted by antioxidants at initiation, spreads quickly in a self-perpetuating, unstoppable chain reaction that intensifies the oxidative destruction [ 5 , 6 ]. The marker of this process is Thiobarbituric Acid Reactive Substances (TBARS) level [ 12 ]. Estimation of TBARS reflects the malondialdehyde (MDA) concentration- the final product of lipid peroxidation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Does Not Influence Subjective Pain Sensation in Inflammatory Bowel Disease Patients

et al. 2021

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Oxidative stress (OS) has been proposed as a significant causative and propagating factor in inflammatory bowel diseases (IBDs). Modulation of OS is possible through antioxidants and inhibition of oxidizing enzymes. Thirty-one IBD patients and thirty-two controls were included in the study. The aim was to examine the levels of OS in colonic tissue of IBD requiring surgical intervention and control group, and their association with pain intensity. Total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) activity, glutathione (GSH) and oxidized glutathione (GSSG) levels, and glutathione peroxidase (GPX) activity as markers of antioxidant defense were determined. Cyclooxygenases activities (Total COX, COX-1 and COX-2) were measured as prooxidant enzymes. Thiobarbituric acid reactive substances (TBARS) concentrations were measured to evaluate lipid peroxidation. Disease activity was assessed, and each subject filled out VAS and Laitinen’s pain assessment scales. Correlation between the OS, pain intensity, disease activity parameters, C-reactive protein (CRP), number of stools passed daily, disease duration, and dietary habits was investigated. No TAC differences were found between the groups. A significant decrease of SOD activity and GSH and GSSG levels was seen in IBD patients vs. controls, while GPX activity was diminished significantly only in CD patients. CAT and COX-1 activity was increased, and COX-2 significantly decreased in IBD. TBARS were significantly higher in CD patients compared to control group. No correlation was found between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers. In our study, OS did not influence pain sensation reported by IBD patients.

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Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis

Cited by 20 publications

References 88 publications

The Impact of Sport Training on Oral Health in Athletes

The Impact of Sport Training on Oral Health in Athletes

Impact of the Glycemic Level on the Salivary Proteome of Middle-Aged and Elderly People With Type 2 Diabetes Mellitus: An Observational Study

Oxidative Stress Does Not Influence Subjective Pain Sensation in Inflammatory Bowel Disease Patients

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