Salivary thromboplastic activity in diabetics and healthy controls

Abstract

Coagulative function of saliva derives from the thromboplastin found in saliva. It may establish hemostasis in the mouth. Salivary disfunction and changes in salivary composition and are frequent complications of diabetes. This study investigated the influence of some local etiologic and systemic factors on salivary thromboplastic activity (STA) in diabetics. In this study, cytological smears and biochemical tests were used. STA was measured by Quick's one stage method, serum glucose by the glucose oxidase method, and salivary protein by the method of Lowry. STA was almost the same in the diabetic and control groups. The only statistically significant difference within the diabetic group was found to be due to antibiotic usage. STA, i.e. clotting time, was 30% longer (114 s) ( p<0.05) and salivary protein (4.07 mg ml(-1)) ( p<0.1) was lower in diabetics not taking antibiotics than in those taking them. No such differences were observed in the healthy controls. Significant linear correlations ( p<0.05) with respect to STA were with salivary protein in the control group (r=0.61) and in the diabetic group (r=0.51) and with antibiotic usage (r=0.29), with leukocyte cell count (r=0.27) in the diabetic group. It can be concluded that salivary cells, proteins and antibiotic usage are important for STA.

Anti-Lipoarabinomannan-Specific Salivary IgA as Prognostic Marker for Leprosy Reactions in Patients and Cellular Immunity in Contacts

“…The present study characterized the salivary anti-LAM secretory IgA response in leprosy patients and their contacts and suggests its use as a prognostic tool for leprosy reactions in patients, and as immunity status in contacts by associating sIgA values with laboratorial and clinical parameters. Saliva has been the study subject as diagnostic or as supplementary tool for diagnosis or for monitoring of oral and systemic diseases ( 24 , 25 ). The simple sample collection, the minimum invasiveness, and diminished contamination risk for healthcare professionals represent important aspects to support the choice of saliva as a promising tool for diagnosis and for monitoring of clinical evolution of patients during treatment and post-discharged.…”

Uso da saliva para diagnóstico da fibrose cística e avaliação da saúde bucal e de parâmetros bioquímicos da saliva de pacientes com fibrose cística atendidos no Hospital de Clínicas da Unicamp

“…Certain systemic diseases like CF, can impair the functioning of the salivary glands and saliva production (quantity and quality), which can affect physical properties and chemical constituents of the saliva [14]. The use of saliva as a diagnostic toll has been supported in some diseases [15][16][17][18][19][20]. In CF, the use of the saliva as a diagnostic tool was investigated [21].…”