Salivirus infection: Systematic review and meta‐analysis of association with gastrointestinal symptoms in children

Abstract

Salivirus (SaV) is a newly described member of the family Picornaviridae that has been associated with gastrointestinal (GI) symptoms, particularly in children. The aim of the present study was to evaluate the prevalence of SaV in symptomatic children and its potential association with GI complications. A systematic search was conducted from 01 December 2009 to 10 December 2020, in three major English databases, including Scopus, PubMed and Web of Science as well as Google scholar search engine. Random effect model-based overall prevalence and odds ratio (OR)were assessed in cross-sectional and case-control studies by STATA 14.1. The random effect model-based pooled prevalence of SaV was 1.6% (95% CI, 0.010-0.022%) and overall OR for all eight case-control studies indicated an association (3.19 with 95% confidence interval 1.35-7.57) that was not statistically significant, due to the small number of studies available. More comprehensive case-control studies in multiple geographies should be conducted on the prevalence of SaV in children.

Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

“…Some previous comprehensive studies have measured the prevalence of viruses and their association with non-communicable disease especially gastrointestinal complications. [194][195][196][197][198] According to our results, the overall pooled prevalence of SaV infection among children with AGE 3.4%. Also, analysis of 20 included case-control studies showed a higher prevalence of SaV infection is found in the case of children with AGE (7.5%) than healthy or asymptomatic controls (4.5%).…”

“…To the best of our knowledge, the current study is the first systematic review and meta‐analysis on the global prevalence and genotyping of SaV. Some previous comprehensive studies have measured the prevalence of viruses and their association with non‐communicable disease especially gastrointestinal complications 194–198 . According to our results, the overall pooled prevalence of SaV infection among children with AGE 3.4%.…”

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

“…Rapid progressions in sequencing technologies, bioinformatics, and metagenomic have led to the discovery of new viruses in recent years. However, while some studies stated the isolation of new viruses from fecal samples of patients with GE, there is still no solid evidence of the association of these viruses with GE ( 4 , 52 , 53 ). They are often neglected in epidemiological studies as they cause milder or asymptomatic infection, and researchers have a higher tendency to detect common enteric viruses and other infectious agents in patients with GE ( 54 – 56 ).…”

An annoying enteric virus: A systematic review and meta‐analysis of human astroviruses and gastrointestinal complications in children

“…Some pathogens are involved in the development of AGE, of which, viruses are responsible for about 70% of cases 2,3 . Rotavirus (RoV), Norovirus (NoV), Enteric Adenovirus (EAdV), Human Astrovirus (HAstV), and Sapovirus (SaV) are the most well‐known viruses in the development of AGE 1,4,5 . In addition, some emerging viruses were recently isolated from faecal samples of patients with AGE.…”